Abstract:
:The endocochlear potential and Na+ activity in the endolymph were simultaneously measured with a double-barreled Na+ selective liquid membrane electrode. The modified Na+ conductance and permeability coefficient of the endolymph-perilymph barrier were calculated from the rate of change in the endolymph Na+ concentration relative to the Na+ electrochemical gradient across the barrier during permanent anoxia. In normal guinea pigs the Na+ conductance of the endolymph-perilymph barrier is approximately 5 times less than its K+ conductance. Exposure to noise or treatment with kanamycin suppresses the cochlear microphonics but does not result in significant alterations in the Na+ permeability of the endolymph-perilymph barrier. It is likely that the Na+ permeability of the endolymph-perilymph barrier is not involved in the physiological processes which lead to the cochlear damage produced by noise or kanamycin.
journal_name
Hear Resjournal_title
Hearing researchauthors
Konishi T,Mori Hdoi
10.1016/0378-5955(84)90045-5subject
Has Abstractpub_date
1984-08-01 00:00:00pages
143-9issue
2eissn
0378-5955issn
1878-5891pii
0378-5955(84)90045-5journal_volume
15pub_type
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