Abstract:
:The conversion of ochratoxin C to ochratoxin A was studied in rats after oral and intravenous administration. The concentration of ochratoxin A in the blood as a function of time was the same after oral administration of equivalent amounts of either ochratoxin C or ochratoxin A. The maximum ochratoxin A concentrations were measured 60 min after administration. Given intravenously, ochratoxin C was also converted to ochratoxin A. Maximum concentrations were reached after 90 min. It is concluded that ochratoxin C is readily converted to ochratoxin A after both oral and intravenous administration. There is reason to believe that a comparable toxicity of the two toxins is based upon this conversion and that only interference with the biotransformation mechanisms may cause a difference in their toxicity.
journal_name
Appl Environ Microbioljournal_title
Applied and environmental microbiologyauthors
Fuchs R,Hult K,Peraica M,Radić B,Plestina Rdoi
10.1128/AEM.48.1.41-42.1984subject
Has Abstractpub_date
1984-07-01 00:00:00pages
41-2issue
1eissn
0099-2240issn
1098-5336journal_volume
48pub_type
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更新日期:1996-08-01 00:00:00