Conversion of ochratoxin C into ochratoxin A in vivo.

Abstract:

:The conversion of ochratoxin C to ochratoxin A was studied in rats after oral and intravenous administration. The concentration of ochratoxin A in the blood as a function of time was the same after oral administration of equivalent amounts of either ochratoxin C or ochratoxin A. The maximum ochratoxin A concentrations were measured 60 min after administration. Given intravenously, ochratoxin C was also converted to ochratoxin A. Maximum concentrations were reached after 90 min. It is concluded that ochratoxin C is readily converted to ochratoxin A after both oral and intravenous administration. There is reason to believe that a comparable toxicity of the two toxins is based upon this conversion and that only interference with the biotransformation mechanisms may cause a difference in their toxicity.

journal_name

Appl Environ Microbiol

authors

Fuchs R,Hult K,Peraica M,Radić B,Plestina R

doi

10.1128/AEM.48.1.41-42.1984

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

41-2

issue

1

eissn

0099-2240

issn

1098-5336

journal_volume

48

pub_type

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