Plutonium-induced wounds in beagles.

Abstract:

:Beagle dogs were given subcutaneous implants of plutonium in their forepaws to mimic hand wounds received by workers accidentally contaminated with plutonium. Ten dogs received 9.46 +/- 0.43 mu Ci of plutonium oxide, and eight dogs received 1.25 +/- 0.60 mu Ci of plutonium nitrate. Surviving dogs were sacrificed at 8 and 5 yr, respectively, after exposure, and radionanalyses were performed on the injection site, regional lymph nodes, liver, spleen and bone. Histopathologic and autoradiographic examinations were performed on injection sites, regional lymph nodes, livers, spleens, kidneys and grossly observed lesions. The injected paws sequestered 21 and 16%, respectively, of the injected activity from plutonium oxide and plutonium nitrate in hypocellular scar tissue. The highest concentrations of translocated radionuclides were found in the regional lymph nodes. Histopathologic and autoradiographic examinations of regional lymph nodes showed that the alpha activity was largely sequestered by scar tissue that replaced lymphoid parenchyma in the plutonium-oxide-injected dogs. In the plutonium-nitrate-injected dogs, activity was widely distributed in relatively intact regional lymph nodes. The liver had the next highest concentration for both radionuclides; activity was present as alpha stars. The spleen had the next highest concentration for plutonium-oxide-injected dogs, although concentrations in the spleen were lower than the skeleton in the plutonium-nitrate-injected dogs. Osteosarcomas and hepatomas were present in one dog injected with plutonium oxide. There does not appear to be any unique risk for dogs related to the subcutaneous route of exposure to plutonium.

journal_name

Health Phys

journal_title

Health physics

authors

Dagle GE,Bristline RW,Lebel JL,Watters RL

doi

10.1097/00004032-198407000-00006

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

73-84

issue

1

eissn

0017-9078

issn

1538-5159

journal_volume

47

pub_type

杂志文章
  • Curve fitting air sample filter decay curves to estimate transuranic content.

    abstract::By testing industry standard techniques for radon progeny evaluation on air sample filters, a new technique is developed to evaluate transuranic activity on air filters by curve fitting the decay curves. The industry method modified here is simply the use of filter activity measurements at different times to estimate ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200401000-00010

    authors: Hayes RB,Chiou HC

    更新日期:2004-01-01 00:00:00

  • Gas mixing for achieving suitable conditions for single point aerosol sampling in a straight tube: experimental and numerical results.

    abstract::Experimental measurements of velocity and tracer gas concentration are taken in a straight tube to evaluate the effectiveness of mixing in achieving conditions as required by ANSI N13.1-1999 for single point extractive sampling from stacks and ducts of nuclear facilities. Mixing is evaluated for inlet turbulent intens...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200301000-00007

    authors: Anand M,McFarland AR,Rajagopal KR

    更新日期:2003-01-01 00:00:00

  • Thorium lung burdens of mineral sands workers.

    abstract::Thorium lung burdens have been measured in workers in the dry separation plants operated by the mineral sands industry in Western Australia. The data have been compared with historical employment records of the worker's exposure to thorium-bearing airborne dusts in order to assess the reliability of personal air sampl...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199508000-00008

    authors: Terry KW,Hewson GS

    更新日期:1995-08-01 00:00:00

  • A case study of selected medical findings among plutonium injectees.

    abstract::Available medical records of plutonium injectees exposed in experimental studies of plutonium biokinetics under Manhattan Engineer District auspices have been reviewed for subsequent medical findings potentially related to the plutonium exposures. Five subjects who had been injected with approximately 11 kBq 239Pu, an...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199905000-00003

    authors: Stebbings JH

    更新日期:1999-05-01 00:00:00

  • Uptake of 244Cm, 238Pu and other radionuclides by trees inhabiting a contaminated flood plain.

    abstract::The plant uptake of 244Cm, 137Cs, 238Pu and 90Sr was measured for trees in a flood plain forest whose soils were contaminated by aqueous discharges from a nuclear-fuel chemical separations facility. Uptake of the naturally occurring radionuclide 226Ra was also measured. The relative availability of the nuclides was 23...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198409000-00003

    authors: Pinder JE 3rd,McLeod KW,Alberts JJ,Adriano DC,Corey JC

    更新日期:1984-09-01 00:00:00

  • Measurement of the attenuation coefficient for Livermore Thoracic Phantom lungs fabricated using contemporary materials.

    abstract::The University of Cincinnati has reproduced the original formulation for the Livermore Thoracic Phantom lungs using contemporary materials and has adopted the linear attenuation coefficient as the primary quality assurance parameter for evaluating the performance capabilities of these new lung phantoms. The Livermore ...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199407000-00005

    authors: Spitz H,Glover S,Liu N,Smith B,Hickman D,Kruchten D,Anderson L

    更新日期:1994-07-01 00:00:00

  • Sensitivity of effective radiating area measurement for therapeutic ultrasound transducers to variations in hydrophone scanning technique.

    abstract::Clinical efficacy and safety may be compromised if output from ultrasonic therapy transducers differs significantly from the indicated value. Space-averaged effective intensities selected for treatment are a ratio of the emitted ultrasonic power to the effective radiating area (ERA). In this study, ERA measurements fo...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198910000-00017

    authors: Bly SH,Hussey RG,Kingsley JP,Dickson AW

    更新日期:1989-10-01 00:00:00

  • An experimental and mathematical analysis of lymphopoiesis dynamics under continuous irradiation.

    abstract::A mathematical model describing the dynamics of lymphopoiesis in mammals continuously exposed to ionizing radiation has been developed. It is based on the theory of chalone regulation of hematopoiesis. The model comprises a system of nine differential equations. Results from the model were compared with our experiment...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199107000-00009

    authors: Zukhbaya TM,Smirnova OA

    更新日期:1991-07-01 00:00:00

  • Statistical analysis of Japanese Thorotrast-administered autopsy cases--1980.

    abstract::In 193 cases autopsied between 1945 and 1980, all persons who had been intravascularly injected with Thorotrast in life, the authors found 131 malignant hepatic tumors, 20 liver cirrhoses, 6 myeloid leukemias, 4 erythroleukemias, 5 aplastic anemias, 4 lung cancers, 1 mesothelioma and 1 osteosarcoma. The causes of deat...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198306001-00025

    authors: Mori T,Kato Y,Aoki N,Hatakeyama S

    更新日期:1983-01-01 00:00:00

  • Nonlinear properties of optical filters--implications for laser safety.

    abstract::Laser safety filter materials must be evaluated at various levels up to the maximum irradiances likely to be encountered, since the absorber may exhibit nonlinear properties. Extreme care is necessary around short-duration lasers due to extremely high peak irradiances in the beam. This is especially true for visible a...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198607000-00007

    authors: Lyon TL,Marshall WJ

    更新日期:1986-07-01 00:00:00

  • Dose response and temporal patterns of radiation-associated solid cancer risks.

    abstract::Findings of the Life Span Study (LSS) cohort of atomic-bomb survivors are a primary source for quantitative risk estimates that underlie radiation protection. Because of the size and length of follow-up, the LSS provides considerable information on both the nature of the dose response and on how radiation-associated e...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/00004032-200307000-00010

    authors: Preston DL,Pierce DA,Shimizu Y,Ron E,Mabuchi K

    更新日期:2003-07-01 00:00:00

  • Diffusive transport of radon in a homogeneous column of dry sand.

    abstract::To validate a model for radon transport in soil, measurements of diffusive radon transport under well-defined and controlled conditions have been made in a homogeneous column of dry sand with an air-filled volume on top. This volume simulates a crawl space. The measurements concern time-dependent diffusive transport w...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199705000-00014

    authors: van der Spoel WH,van der Graaf ER,de Meijer RJ

    更新日期:1997-05-01 00:00:00

  • Mitigating radiation-induced toxicity: an overview of new approaches developed at the French Military Biomedical Research Institute.

    abstract::Acute radiation syndrome represents the clinical response of radiation-sensitive key tissues (i.e., hematopoietic, gastrointestinal and neurovascular) following exposure to high doses of ionizing radiation. In this context, the hematopoietic syndrome remains the first therapeutic challenge. Today, identifying new drug...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/HP.0000000000000039

    authors: Drouet M,Hérodin F

    更新日期:2014-06-01 00:00:00

  • Reconstruction of long-lived radionuclide intakes for Techa riverside residents: strontium-90.

    abstract::Releases of radioactive materials from the Mayak Production Association in 1949-1956 resulted in contamination of the Techa River; a nuclide of major interest was 90Sr, which downstream residents consumed with water from the river and with milk contaminated by cows' consumption of river water and contaminated pasture....

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e318206d0ff

    authors: Tolstykh EI,Degteva MO,Peremyslova LM,Shagina NB,Shishkina EA,Krivoshchapov VA,Anspaugh LR,Napier BA

    更新日期:2011-07-01 00:00:00

  • On the discrepancy between epidemiologic studies in individuals of lung cancer and residential radon and Cohen's ecologic regression.

    abstract::There is still substantial confusion in the radiation effects community about the inherent limitations of ecologic analysis. As a result, inordinate attention has been given to the discrepant results of Cohen, in which a negative estimate is observed for the regression of county mortality rates for lung cancer on esti...

    journal_title:Health physics

    pub_type: 评论,杂志文章

    doi:10.1097/00004032-199807000-00001

    authors: Lubin JH

    更新日期:1998-07-01 00:00:00

  • Scrap metals industry perspective on radioactive materials.

    abstract::With more than 80 reported/confirmed accidental melts worldwide since 1983 and still counting, potential contamination by radioactive materials remains as a major concern among recycled scrap and steel companies. Some of these events were catastrophic and have cost the industry millions of dollars in business and, at ...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/01.HP.0000236781.15424.4a

    authors: Turner R

    更新日期:2006-11-01 00:00:00

  • Radiological health effects models for nuclear power plant accident consequence analysis.

    abstract::Improved health effects models have been developed for assessing the early effects, late somatic effects and genetic effects that might result from low-LET radiation exposures to populations following a major accident in a nuclear power plant. All the models have been developed in such a way that the dynamics of popul...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198904000-00001

    authors: Evans JS,Moeller DW

    更新日期:1989-04-01 00:00:00

  • Apparent high tritium intake by a radiation worker at the University of Rochester.

    abstract::On 20 September 1999, a urine sample submitted by a University of Rochester radiation worker was noted to have a count rate of about 759,500 disintegrations per minute (dpm) per milliliter as analyzed on the Radiation Safety Unit (RSU) Packard liquid sintillation counter. The sample was recounted that day with variabl...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-200005001-00006

    authors: Karam PA

    更新日期:2000-05-01 00:00:00

  • Reassessment of Internal Thyroid Doses to 1,080 Children Examined in a Screening Survey after the 2011 Fukushima Nuclear Disaster.

    abstract::The dose reconstruction of populations potentially affected by the accident at the Fukushima Daiichi nuclear power plant in March 2011 is of great importance. However, it has been difficult to assess internal thyroid doses to Fukushima residents (mainly from their intake of I) due to the lack of direct measurements. F...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000001125

    authors: Kim E,Yajima K,Hashimoto S,Tani K,Igarashi Y,Iimoto T,Ishigure N,Tatsuzaki H,Akashi M,Kurihara O

    更新日期:2020-01-01 00:00:00

  • Future role of the NCRP in radiation health protection.

    abstract::The predecessor organizations of the National Council on Radiation Protection and Measurements (NCRP) were established in 1929 (the U.S. Advisory Committee on X-Ray and Radium Protection) and in 1946 (the National Committee on Radiation Protection and Measurements). In 1964, the NCRP was formally chartered by the U.S....

    journal_title:Health physics

    pub_type: 历史文章,杂志文章,评审

    doi:10.1097/00004032-200409000-00014

    authors: Tenforde TS

    更新日期:2004-09-01 00:00:00

  • An investigation into the prevalence of thyroid disease on Kwajalein Atoll, Marshall Islands.

    abstract::The prevalence of thyroid nodules and thyroid cancer was studied in the indigenous population residing on Ebeye Island, Kwajalein Atoll, in the Republic of the Marshall Islands. This island, centrally located in the nation, is home to about 25% of the nation's population, many who have migrated there from other atolls...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199707000-00017

    authors: Takahashi T,Trott KR,Fujimori K,Simon SL,Ohtomo H,Nakashima N,Takaya K,Kimura N,Satomi S,Schoemaker MJ

    更新日期:1997-07-01 00:00:00

  • Attributable risk for radiation in the presence of other risk factors.

    abstract::Two motivations for studying radiation risk are (1) to quantify the magnitude of risk as an aid to setting radiation protection standards and (2) to understand causality as an aid to assigning compensation for radiation exposed individuals whose disease or death may have been related to radiation exposure. Although it...

    journal_title:Health physics

    pub_type: 杂志文章,评审

    doi:10.1097/HP.0b013e3181db29fd

    authors: Cologne J,Cullings H,Furukawa K,Ross P

    更新日期:2010-11-01 00:00:00

  • Differences in lung cancer mortality trends from 1986-2012 by radon risk areas in British Columbia, Canada.

    abstract::Residential exposure to radon gas is associated with increased risk of lung cancer, especially in smokers. Most evidence about the health effects of radon has been derived from meta-analyses on global epidemiologic studies, but administrative data can help public health authorities to explore the local impacts. Eighty...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000005

    authors: Henderson SB,Rauch SA,Hystad P,Kosatsky T

    更新日期:2014-05-01 00:00:00

  • Design of a positionally sensitive laser-heated thermoluminescent detector system.

    abstract::The design and performance of a positionally sensitive system for the laser read-out of dosimetric information contained in LiF chips and a specially designed composite detector having a thin LiF layer is reported. A 2 cm X 3 cm X 0.254 mm LiF layer was successfully manufactured with a glass backing; however, this was...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-199010000-00004

    authors: Kearfott KJ,Grupen-Shemansky ME

    更新日期:1990-10-01 00:00:00

  • Mutant frequencies in workers at the Sellafield installation.

    abstract::The frequency of hypoxanthine-guanine phosphoribosyltransferase (hprt) mutations has been determined in the peripheral T-lymphocytes of 18 workers at the Sellafield nuclear reprocessing installation with cumulative recorded radiation doses of about 500 mSv or more in comparison with a matched control group of 18 worke...

    journal_title:Health physics

    pub_type: 临床试验,杂志文章

    doi:10.1097/00004032-199503000-00011

    authors: Cole J,Arlett CF,Green MH,Holdsworth D,Tawn EJ,Bridges BA

    更新日期:1995-03-01 00:00:00

  • Spatial and temporal distribution of energy.

    abstract::Studies of the spatial and temporal distribution of microscopic radiation doses lead to potentially important questions regarding conventional approaches to radiation protection. The short ranges of alpha-particle and Auger-electron emissions from radionuclides lead to uncertainties in assessing their hazards. The con...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198808000-00015

    authors: Goodhead DT

    更新日期:1988-08-01 00:00:00

  • Characterization of exposures to workers covered under the U.S. Energy Employees Compensation Act.

    abstract::Since the mid-1940s, hundreds of thousands of workers have been engaged in nuclear weapons-related activities for the U.S. Department of Energy (DOE) and its predecessor agencies. In 2000, Congress promulgated the Energy Employees Occupational Illness Compensation Program Act of 2000 (EEOICPA), which provides monetary...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0000000000000008

    authors: Neton JW

    更新日期:2014-02-01 00:00:00

  • Twelve years of follow up of cases with old 241Am internal contamination.

    abstract::A group of workers internally contaminated with Am have been followed for about 12 years. The source of contamination was AmO2 powder used for production of AmBe neutron sources and other applications. The production of some radionuclide sources included chemical treatment of the original material, which transformed t...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/HP.0b013e3181d18e2e

    authors: Malátová I,Vrba T,Becková V,Pospísilová H

    更新日期:2010-10-01 00:00:00

  • Uranium concentrations in South African herbal remedies.

    abstract::South Africa contains some of the world's largest mineral deposits, which include uranium. Uranium is mined as a by-product of gold production. The uranium content of the surface soil and groundwater in South Africa has been measured and shows marked variation, depending on location. Herbal remedies are collected by t...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/01.hp.0000168614.97386.43

    authors: Steenkamp V,Stewart MJ,Chimuka L,Cukrowska E

    更新日期:2005-12-01 00:00:00

  • Fallout 239/240Pu and 238Pu in human tissues from the Federal Republic of Germany.

    abstract::To determine the present level of plutonium in human tissues of people in the F.R.G., due solely to fallout from weapons testing, 30 sets of tissues and bones from Munich residents were obtained at autopsy. Each set of tissues consisted of the entire lung, the entire liver, 300 g vertebrae, 300 g ribs and the lymph no...

    journal_title:Health physics

    pub_type: 杂志文章

    doi:10.1097/00004032-198306001-00042

    authors: Bunzl K,Kracke W

    更新日期:1983-01-01 00:00:00