Regulation of fibrinogen synthesis by plasmin-derived fragments of fibrinogen and fibrin: an indirect feedback pathway.

abstract：:Invasive potentials of carcinomas greatly contribute to their metastasis, which is a major threat in most cancers. We have recently shown that Arf6 plays a pivotal role in breast cancer invasive activities and identified AMAP1 as an effector of GTP-Arf6 in invasion. Expression of AMAP1 correlates well with invasive ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hashimoto S,Hirose M,Hashimoto A,Morishige M,Yamada A,Hosaka H,Akagi K,Ogawa E,Oneyama C,Agatsuma T,Okada M,Kobayashi H,Wada H,Nakano H,Ikegami T,Nakagawa A,Sabe H

更新日期：2006-05-02 00:00:00

abstract：:Glioblastoma is the most common primary malignant brain tumor of adults and one of the most lethal of all cancers. Patients with this disease have a median survival of 15 months from the time of diagnosis despite surgery, radiation, and chemotherapy. New treatment approaches are needed. Recent works suggest that gliob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horvath S,Zhang B,Carlson M,Lu KV,Zhu S,Felciano RM,Laurance MF,Zhao W,Qi S,Chen Z,Lee Y,Scheck AC,Liau LM,Wu H,Geschwind DH,Febbo PG,Kornblum HI,Cloughesy TF,Nelson SF,Mischel PS

更新日期：2006-11-14 00:00:00

abstract：:RNase T2 enzymes are conserved in most eukaryotic genomes, and expression patterns and phylogenetic analyses suggest that they may carry out an important housekeeping role. However, the nature of this role has been elusive. Here we show that RNS2, an intracellular RNase T2 from Arabidopsis thaliana, is essential for n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hillwig MS,Contento AL,Meyer A,Ebany D,Bassham DC,Macintosh GC

更新日期：2011-01-18 00:00:00

abstract：:Glycoprotein Ib is a surface membrane glycoprotein of platelets that functions as a receptor for von Willebrand factor. It is a heterodimer composed of an alpha and a beta chain linked by a disulfide bond(s). A phage lambda gt11 cDNA expression library prepared from mRNA from a human erythroleukemia cell line, HEL, wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lopez JA,Chung DW,Fujikawa K,Hagen FS,Papayannopoulou T,Roth GJ

更新日期：1987-08-01 00:00:00

abstract：:The primary product of biological nitrogen fixation, ammonia, reversibly regulates nitrogenase activity in a variety of diazotrophs by a process called "NH4(+)-switch-off/on." Strong correlative evidence from work in Azospirillum lipoferum and Rhodospirillum rubrum indicates that this regulation involves both the inac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu H,Burris RH,Roberts GP

更新日期：1990-03-01 00:00:00

abstract：:We describe a Kappa-on-Heavy (KoH) mouse that produces a class of highly diverse, fully human, antibody-like agents. This mouse was made by replacing the germline variable sequences of both the Ig heavy-chain (IgH) and Ig kappa (IgK) loci with the human IgK germline variable sequences, producing antibody-like molecule...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Macdonald LE,Meagher KA,Franklin MC,Levenkova N,Hansen J,Badithe AT,Zhong M,Krueger P,Rafique A,Tu N,Shevchuk J,Wadhwa S,Ehrlich G,Bautista J,Grant C,Esau L,Poueymirou WT,Auerbach W,Morton L,Babb R,Chen G,Huang

更新日期：2020-01-07 00:00:00

abstract：:Adenosine, dibutyryl cyclic AMP, monobutyryl cyclic AMP, cyclic AMP, and 5'-AMP have a remarkable morphogenetic effect on cultured iris epithelial cells obtained from adult newt. They alter the broad undulating membrane of the cell into branching strands of cytoplasm, a configuration that has been named "stellate." Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ortiz JR,Yamada T,Hsie AW

更新日期：1973-08-01 00:00:00

abstract：:A recombinant plasmid containing a DNA segment complementary to rat liver albumin mRNA has been constructed, cloned, and used to examine the organization of albumin gene. The 18S fraction of total liver poly(A)-containing RNA was copied into a double-stranded cDNA by avian myeloblastosis virus reverse transcriptase an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kioussis D,Hamilton R,Hanson RW,Tilghman SM,Taylor JM

更新日期：1979-09-01 00:00:00

abstract：:Art forgeries have existed since antiquity, but with the recent rapidly expanding commercialization of art, the approach to art authentication has demanded increasingly sophisticated detection schemes. So far, the most conclusive criterion in the field of counterfeit detection is the scientific proof of material anach...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hendriks L,Hajdas I,Ferreira ESB,Scherrer NC,Zumbühl S,Smith GD,Welte C,Wacker L,Synal HA,Günther D

更新日期：2019-07-02 00:00:00

abstract：:Anti-immunoglobulin treatment of fura-2-loaded Daudi cells induces a calcium mobilization as judged by the increase in the fluorescence of the dye fura-2, AM. No calcium mobilization by N-fMet-Leu-Phe is observed in these cells. However, exposure of the cells to N-fMet-Leu-Phe after the first hit with anti-immunoglobu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalunta CI,Kaptein JS,Niedzin H,Scott SJ,Lee GH,Lad PM

更新日期：1988-12-01 00:00:00

abstract：:We have devised a simple and efficient cDNA cloning strategy that overcomes many of the difficulties encountered in obtaining full-length cDNA clones of low-abundance mRNAs. In essence, cDNAs are generated by using the DNA polymerase chain reaction technique to amplify copies of the region between a single point in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frohman MA,Dush MK,Martin GR

更新日期：1988-12-01 00:00:00

abstract：:Cocaine exposure in utero causes severe alterations in the development of the central nervous system. To study the basis of these teratogenic effects in vitro, we have used cocultures of neurons and glial cells from mouse embryonic brain. Cocaine selectively affected embryonic neuronal cells, causing first a dramatic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nassogne MC,Evrard P,Courtoy PJ

更新日期：1995-11-21 00:00:00

abstract：:On the basis of task-related imaging studies in normal human subjects, it has been suggested that two attention systems exist in the human brain: a bilateral dorsal attention system involved in top-down orienting of attention and a right-lateralized ventral attention system involved in reorienting attention in respons...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fox MD,Corbetta M,Snyder AZ,Vincent JL,Raichle ME

更新日期：2006-06-27 00:00:00

abstract：:Transcription termination is a critical step in the control of gene expression. One of the major termination mechanisms is mediated by Rho factor that dissociates the complex mRNA-DNA-RNA polymerase upon binding with RNA polymerase. Rho promotes termination at the end of operons, but it can also terminate transcriptio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva IJ,Barahona S,Eyraud A,Lalaouna D,Figueroa-Bossi N,Massé E,Arraiano CM

更新日期：2019-02-19 00:00:00

abstract：:Tidal deltas are characterized by a dendritic network of distributaries that transport water and sediments to the ocean. Here, I show that the distributaries self-organize to uniformly redistribute the tidal prism across the entire delta system. The 2 opposite mechanisms of channel formation by avulsion and channel ab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fagherazzi S

更新日期：2008-12-02 00:00:00

abstract：:The interleukin 2 (IL-2) receptor (IL-2R) is a multisubunit receptor that includes three major IL-2 binding subunits, the IL-2R alpha, beta, and gamma chains. We have detected and analyzed cooperative interactions between the IL-2R alpha and beta chains (IL-2R alpha and IL-2R beta, respectively) in COS cells transfect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roessler E,Grant A,Ju G,Tsudo M,Sugamura K,Waldmann TA

更新日期：1994-04-12 00:00:00

abstract：:We know a great deal about the cellular response to starvation via AMPK, but less is known about the reaction to nutrient excess. Insulin resistance may be an appropriate response to nutrient excess, but the cellular sensors that link these parameters remain poorly defined. In the present study we provide evidence tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoehn KL,Salmon AB,Hohnen-Behrens C,Turner N,Hoy AJ,Maghzal GJ,Stocker R,Van Remmen H,Kraegen EW,Cooney GJ,Richardson AR,James DE

更新日期：2009-10-20 00:00:00

abstract：:The yeast flora found in the major substrates of Drosophila mojavensis and in larval guts was studied both qualitatively and quantitatively. Quantitative studies show that, in four of the five substrates tested, the larvae did not contain a random sample of the yeasts present in the substrates. One widely distributed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fogleman JC,Starmer WT,Heed WB

更新日期：1981-07-01 00:00:00

abstract：:The Paleocene-Eocene Thermal Maximum (PETM) (∼56 Ma) was a ∼170,000-y (∼170-kyr) period of global warming associated with rapid and massive injections of 13C-depleted carbon into the ocean-atmosphere system, reflected in sedimentary components as a negative carbon isotope excursion (CIE). Carbon cycle modeling has ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frieling J,Svensen HH,Planke S,Cramwinckel MJ,Selnes H,Sluijs A

更新日期：2016-10-25 00:00:00

abstract：:The effect of x-rays on the rate of semiconservative DNA replication was investigated by autoradiography in single cells obtained from normal individuals and from patients having ataxia-telangiectasia (AT). In the five AT cell strains studied, the rate of DNA synthesis was inhibited to a lesser extent that in two norm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaspers NG,Bootsma D

更新日期：1982-04-01 00:00:00

abstract：:In eukaryotes, RNA polymerase I transcription is controlled by DNA elements located within the spacers that separate the tandemly arranged rRNA genes. Unlike rRNA coding sequences, the intergenic spacers evolve rapidly and have little sequence similarity even among closely related species. Nonetheless, the arrangement...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doelling JH,Gaudino RJ,Pikaard CS

更新日期：1993-08-15 00:00:00

abstract：:Capsaicin is a unique alkaloid of the plant kingdom restricted to the genus Capsicum. Capsaicin is the pungency factor, a bioactive molecule of food and of medicinal importance. Capsaicin is useful as a counterirritant, antiarthritic, analgesic, antioxidant, and anticancer agent. Capsaicin biosynthesis involves conden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prasad BC,Kumar V,Gururaj HB,Parimalan R,Giridhar P,Ravishankar GA

更新日期：2006-09-05 00:00:00

abstract：:Construction of deletion derivative plasmids and cloning of restriction fragments from plasmids containing the Salmonella typhimurium origin of replication (ori) were used to locate the functional origin to within a DNA fragment of 296 base pairs between the genes uncB and asn. The nucleotide sequence of the S. typhim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zyskind JW,Smith DW

更新日期：1980-05-01 00:00:00

abstract：:Maximum likelihood analysis for linkage between autosomal dominant aniridia and 12 biochemical and serological markers in a single large family showed a probable linkage between autosomal dominant aniridia and the enzyme acid phosphatase-1. The presence of an autosomal dominant aniridia gene linked to acid phosphatase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrell RE,Chakravarti A,Hittner HM,Riccardi VM

更新日期：1980-03-01 00:00:00

abstract：:Previous studies have shown that binding of interleukin 1 (IL-1) to its receptor and intracellular processing of the IL-1/IL-1 receptor complex appear to be different in B- and T-lymphocyte cell lines. In this study we used a B-lymphoid cell line, 70Z/3, and T-lymphoid cell line, EL-4 6.1 C10, to explore further the d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bomsztyk K,Sims JE,Stanton TH,Slack J,McMahan CJ,Valentine MA,Dower SK

更新日期：1989-10-01 00:00:00

abstract：:Determining trend and implementing detrending operations are important steps in data analysis. Yet there is no precise definition of "trend" nor any logical algorithm for extracting it. As a result, various ad hoc extrinsic methods have been used to determine trend and to facilitate a detrending operation. In this art...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu Z,Huang NE,Long SR,Peng CK

更新日期：2007-09-18 00:00:00

abstract：:The ability to modulate the collective properties of correlated electron systems at their interfaces and surfaces underpins the burgeoning field of "designer" quantum materials. Here, we show how an electronic reconstruction driven by surface polarity mediates a Stoner-like magnetic instability to itinerant ferromagne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazzola F,Sunko V,Khim S,Rosner H,Kushwaha P,Clark OJ,Bawden L,Marković I,Kim TK,Hoesch M,Mackenzie AP,King PDC

更新日期：2018-12-18 00:00:00

abstract：:Understanding plant metabolism as an integrated system is essential for metabolic engineering aimed at the effective production of compounds useful to human life and the global environment. The "omics" approach integrates transcriptome and metabolome data into a single data set and can lead to the identification of un...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirai MY,Sugiyama K,Sawada Y,Tohge T,Obayashi T,Suzuki A,Araki R,Sakurai N,Suzuki H,Aoki K,Goda H,Nishizawa OI,Shibata D,Saito K

更新日期：2007-04-10 00:00:00

abstract：:Expansins are unusual proteins discovered by virtue of their ability to mediate cell wall extension in plants. We identified cDNA clones for two cucumber expansins on the basis of peptide sequences of proteins purified from cucumber hypocotyls. The expansin cDNAs encode related proteins with signal peptides predicted ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shcherban TY,Shi J,Durachko DM,Guiltinan MJ,McQueen-Mason SJ,Shieh M,Cosgrove DJ

更新日期：1995-09-26 00:00:00

abstract：:Fragility is an empirical property that describes how abruptly a glass-forming material solidifies upon supercooling. The degree of fragility carries important implications for the functionality and processability of a material, as well as for our fundamental understanding of the glass transition. However, the microst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ciarella S,Biezemans RA,Janssen LMC

更新日期：2019-12-10 00:00:00