Enhancement of the release reaction not accompanied with enhanced phosphatidylinositol turnover in the reserpinized rabbit blood platelets.

Abstract:

:Thrombin-induced platelet release reaction examined with secretion of calcium and N-acetylglucosaminidase was significantly enhanced in the platelets from reserpine-treated rabbits as compared with the control. On the other hand, 32P-incorporation into phosphatidic acid was suppressed in the reserpinized platelets in activated state. Thrombin induced phosphatidylinositol (PI)-breakdown, which was examined by decreases in radioactivity and content of PI, and an increase in diacylglycerol, was not enhanced in the reserpinized platelets as compared with the control. The phosphorylation of the specific protein coupled to thrombin-induced platelet PI-breakdown was not stimulated in the reserpinized platelets as compared with the control. In contrast to PI, PC-degradation by thrombin was significantly stimulated in the reserpinized platelets. Possible existence of pathway(s) other than that associated with an enhancement of PI-turnover is conceivable as a mechanism involved in platelet release reaction.

journal_name

Thromb Haemost

authors

Watanabe Y,Soda M,Fukamachi N,Kobayashi B

subject

Has Abstract

pub_date

1983-08-30 00:00:00

pages

595-600

issue

2

eissn

0340-6245

issn

2567-689X

journal_volume

50

pub_type

杂志文章
  • A comparative multi-laboratory assessment of three factor VIII/von Willebrand factor concentrates.

    abstract::Five expert laboratories have participated in a cross-laboratory study to co-evaluate and compare three commercial Factor VIII/von Willebrand factor (VWF) concentrates. A total of nine factor concentrate lots were evaluated, comprising AHF (High Purity) (AHF HP; x3), Biostate (x3) and Humate/Haemate (x3). All laborato...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Favaloro EJ,Bukuya M,Martinelli T,Tzouroutis J,Duncan E,Welldon K,Collecutt M,Aumann H,Thom J,Gilmore G

    更新日期:2002-03-01 00:00:00

  • Adiponectin inhibits tissue factor expression and enhances tissue factor pathway inhibitor expression in human endothelial cells.

    abstract::Tissue factor (TF) plays a pivotal role in thrombus formation and atherogenesis in acute coronary syndrome. Tissue factor pathway inhibitor (TFPI) is a specific physiological inhibitor of TF/FVIIa complex that regulates TF-induced coagulation. Adiponectin (Adp) is an adipocyte-specific adipocytokine with anti-atheroge...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Chen YJ,Zhang LQ,Wang GP,Zeng H,Lü B,Shen XL,Jiang ZP,Chen FP

    更新日期:2008-08-01 00:00:00

  • Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effects on prothrombin time, activated partial thromboplastin time, and Ecarin Clotting Time.

    abstract::Treatment with the direct thrombin inhibitor argatroban (ARG) is often followed by vitamin K-antagonist treatment (VKA). Phenprocoumon (PC) and acenocoumarol (AC) are frequently used in Europe. The standard monitoring test for VKA, pro-thrombin time (PT), is prolonged by direct thrombin inhibitors. Therefore the Inter...

    journal_title:Thrombosis and haemostasis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1160/TH03-12-0794

    authors: Harder S,Graff J,Klinkhardt U,von Hentig N,Walenga JM,Watanabe H,Osakabe M,Breddin HK

    更新日期:2004-06-01 00:00:00

  • CREB binding to the hypoxia-inducible factor-1 responsive elements in the plasminogen activator inhibitor-1 promoter mediates the glucagon effect.

    abstract::Plasminogen activator inhibitor-1 (PAI-1) controls the regulation of the fibrinolytic system in blood by inhibiting both urokinase-type and tissue-type plasminogen activators. Enhanced levels of PAI-1 are related to pathological conditions associated with hypoxia or hyperinsulinemia. In this study, we investigated the...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Dimova EY,Jakubowska MM,Kietzmann T

    更新日期:2007-08-01 00:00:00

  • Predictive value of coagulation markers concerning clinical outcome 90 days after anterior myocardial infarction.

    abstract::To study the predictive value of coagulation markers concerning clinical outcome, prothrombin fragment F1.2 (F1.2), fibrin monomer antigen (FM), D-Dimer (DD), and fibrinogen were measured in plasma samples drawn 2 and 7 days after acute myocardial infarction (AMI) in 314 consecutive patients randomized in a clinical t...

    journal_title:Thrombosis and haemostasis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Dempfle CE,Kontny F,Abildgaard U

    更新日期:1999-05-01 00:00:00

  • Protean clinical presentation of antiphospholipid-protein antibodies (APA).

    abstract::Antiphospholipid-protein antibodies (APA) are a family of immunoglobulins which have been defined by varying laboratory test systems. Lupus anticoagulants (LA) and anticardiolipin antibodies (ACA) are the two most prominent members of this family of antibodies. LA are detected utilizing various phospholipid (PL) depen...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:

    authors: Triplett DA

    更新日期:1995-07-01 00:00:00

  • Unbalanced effects of dermatan sulfates with different sulfation patterns on coagulation, thrombosis and bleeding.

    abstract::We compared the anticoagulant, antithrombotic and bleeding effects of highly sulfated dermatan sulfates from invertebrates and their mammalian counterpart. An invertebrate dermatan sulfate containing 2-O-sulfated alpha-L-iduronic acid and 4-O-sulfated N-acetyl-beta-D-galactosamine residues is a potent anticoagulant du...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Vicente CP,Zancan P,Peixoto LL,Alves-Sá R,Araújo FS,Mourão PA,Pavão MS

    更新日期:2001-11-01 00:00:00

  • Comparison of clinical probability-adjusted D-dimer and age-adjusted D-dimer interpretation to exclude venous thromboembolism.

    abstract::Two new strategies for interpreting D-dimer results have been proposed: i) using a progressively higher D-dimer threshold with increasing age (age-adjusted strategy) and ii) using a D-dimer threshold in patients with low clinical probability that is twice the threshold used in patients with moderate clinical probabili...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH17-03-0182

    authors: Takach Lapner S,Julian JA,Linkins LA,Bates S,Kearon C

    更新日期:2017-10-05 00:00:00

  • Regulation by nitric oxide of endotoxin-induced tissue factor and plasminogen activator inhibitor-1 in endothelial cells.

    abstract::The increase in nitric oxide (NO) production in lipopolysaccharide (LPS)-induced sepsis is thought to contribute to the development of shock. However, NO could also play an antithrombotic role. Little is known about the modulating effect of NO on the endothelial overexpression and production of tissue factor (TF) and ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Pérez-Ruiz A,Montes R,Velasco F,López-Pedrera C,Antonio Páramo J,Orbe J,Hermida J,Rocha E

    更新日期:2002-12-01 00:00:00

  • Pulmonary embolism in patients with upper extremity DVT associated to venous central lines--a prospective study.

    abstract::We performed a prospective study in 86 consecutive patients with central vein catheter-related deep venous thrombosis (DVT) of the upper extremity, to evaluate the prevalence of pulmonary embolism (PE), and to identify clinical variables that would increase the likelihood of developing PE in an individual patient. Sin...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Monreal M,Raventos A,Lerma R,Ruiz J,Lafoz E,Alastrue A,Llamazares JF

    更新日期:1994-10-01 00:00:00

  • Antithrombin III: a database of mutations.

    abstract::Elucidation of the molecular defects responsible for antithrombin III deficiency is proceeding rapidly. In order that a record is kept of the new and duplicated mutations that are found, we have compiled a database that we plan to update annually. In this, the first report of the database, we list 6 antithrombin III l...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Lane DA,Ireland H,Olds RJ,Thein SL,Perry DJ,Aiach M

    更新日期:1991-12-02 00:00:00

  • Pleckstrin homology domains and phospholipid-induced cytoskeletal reorganization.

    abstract::At the moment of hemostasis, the platelet must be able to reorganize its cytoskeleton through a complexly orchestrated signaling cascade that is regulated, in part, by polyphosphoinositides. In the past 6 years, evidence has accumulated that PH domains bind these polyphosphoinositides and play a role in cytoskeletal c...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:

    authors: Ma AD,Abrams CS

    更新日期:1999-08-01 00:00:00

  • Porcine platelet von Willebrand antigen II (vW AgII): inhibitory effect on collagen-induced aggregation and comparative distribution with human platelets.

    abstract::Von Willebrand factor (vWF) is synthesized by human endothelial cells and megakaryocytes as a large precursor, the pre-provWF, which is finally cleaved into the propolypeptide of vWF (pp-vWF) and the mature vWF. We have purified in parallel the pp-vWF and the GP IIb-IIIa from porcine platelets. The N-terminus comparat...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Royo T,Vidal M,Badimon L

    更新日期:1998-10-01 00:00:00

  • Enhancement of lipoprotein lipase activity by tissue factor pathway inhibitor.

    abstract::The effect of a basic synthetic peptide, representing the C-terminal region of tissue factor pathway inhibitor (TFPI - Lys254 - Met276), as well as that of the whole protein, on the activity of lipoprotein lipase (LPL) is described. The activity of bovine LPL was measured by chromogenic assay using a water-soluble chr...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Mukherjee M,Kakkar VV

    更新日期:1999-12-01 00:00:00

  • Transient receptor potential protein subunit assembly and membrane distribution in human platelets.

    abstract::We have previously suggested that the human homologue of the Drosophila transient receptor potential protein, TRPC1, is involved in conducting store-operated Ca2+ entry (SOCE) in human platelets since an antibody raised against the pore-forming region of TRPC1 inhibited SOCE. Here we have investigated plasma membrane ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH05-06-0391

    authors: Brownlow SL,Sage SO

    更新日期:2005-10-01 00:00:00

  • Functional consequences of mutations in amino acid residues that stabilize calcium binding to the first epidermal growth factor homology domain of human protein C.

    abstract::Charge-to-alanine mutations of three amino acid residues, viz, D46, D48, and D/Hya71, which are known to be important in stabilizing Ca2+ binding to epidermal growth factor (EGF) domains of vitamin K-dependent blood coagulation proteins, have been engineered into recombinant human protein C (r-PC). The resulting varia...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Geng JP,Cheng CH,Castellino FJ

    更新日期:1996-11-01 00:00:00

  • Fibrinogen adsorption, platelet adhesion and thrombin generation at heparinized surfaces exposed to flowing blood.

    abstract::Thrombus formation at an artificial surface in contact with blood is a complex process that encompasses accretion of platelets from flowing blood and fibrin deposition. Platelet adhesion and fibrin formation are intimately intertwined reactions that are triggered by different sets of surface adsorbed plasma proteins. ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Keuren JF,Wielders SJ,Willems GM,Morra M,Lindhout T

    更新日期:2002-04-01 00:00:00

  • Treatments for stroke prevention in atrial fibrillation: a network meta-analysis and indirect comparisons versus dabigatran etexilate.

    abstract::Patients with atrial fibrillation at moderate to high risk of stroke are not always anticoagulated despite a lack of contraindications to vitamin K antagonists (VKAs) like warfarin. These patients are treated with aspirin, aspirin-clopidogrel combination therapy or even receive no thromboprophylaxis. The oral direct t...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,meta分析

    doi:10.1160/TH10-10-0642

    authors: Roskell NS,Lip GY,Noack H,Clemens A,Plumb JM

    更新日期:2010-12-01 00:00:00

  • Ex vivo evaluation of anti-GPVI antibody in cynomolgus monkeys: dissociation between anti-platelet aggregatory effect and bleeding time.

    abstract::Recent progress in the understanding of thrombus formation has suggested an important role of glycoprotein (GP)VI. In contrast to its pivotal role in collagen-induced platelet activation, it has been suggested that its blockade does not induce massive bleeding tendency. To demonstrate the dissociation between inhibito...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Matsumoto Y,Takizawa H,Nakama K,Gong X,Yamada Y,Tandon NN,Kambayashi J

    更新日期:2006-08-01 00:00:00

  • A study of the possible role of mesothelium as a surface for flowing blood.

    abstract::Mouse mesothelium has been examined as a surface for supporting blood flow. We have examined ten pieces of intact mesothelium and ten pieces of damaged mesothelium following 10 min exposure to flowing blood in a Baumgartner chamber. Scanning electron microscopy of the intact specimens demonstrated no adhering blood pl...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Clarke JM,Pittilo RM,Machin SJ,Woolf N

    更新日期:1984-02-28 00:00:00

  • The C50T polymorphism of the cyclooxygenase-1 gene and the risk of thrombotic events during low-dose therapy with acetyl salicylic acid.

    abstract::Aspirin prevents thrombotic events by inhibiting platelet cyclooxygenase-1 (COX-1), thus reducing thromboxane A2 formation and platelet aggregation. The C50T polymorphism of COX-1 is associated with an impaired inhibition of both thromboxane production and in-vitro platelet aggregation by aspirin. We studied whether t...

    journal_title:Thrombosis and haemostasis

    pub_type: 临床试验,杂志文章

    doi:10.1160/TH08-03-0172

    authors: Clappers N,van Oijen MG,Sundaresan S,Brouwer MA,Te Morsche RH,Keuper W,Peters WH,Drenth JP,Verheugt FW

    更新日期:2008-07-01 00:00:00

  • Platelet Glycoprotein VI Haplotypes and the Presentation of Paediatric Sepsis.

    abstract::Sepsis triggers a complex series of pathophysiologic events involving inflammatory responses and coagulation abnormalities. While circulating blood platelets are well-characterized for their contributions to coagulation, increasingly platelet-dependent effects on inflammation are being recognized. Here, we focus on th...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1055/s-0038-1676794

    authors: Asfari A,Dent JA,Corken A,Herington D,Kaliki V,Sra N,Hefley G,Pasala S,Prodhan P,Ware J

    更新日期:2019-03-01 00:00:00

  • The influence of factor V Leiden and G20210A prothrombin mutation on the presence of residual vein obstruction after idiopathic deep-vein thrombosis of the lower limbs.

    abstract::It was our aim to assess whether factor V Leiden (FVL) and G20210A prothrombin (FII) mutation are associated with the presence of residual vein obstruction (RVO) after a standard course of anticoagulation for a first episode of idiopathic proximal deep-vein thrombosis (DVT) of the lower limbs, with or without symptoma...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1160/TH12-01-0041

    authors: Cosmi B,Legnani C,Pengo V,Ghirarduzzi A,Testa S,Poli D,Prisco D,Tripodi A,Palareti G,PROLONG Investigators (on behalf of FCSA, Italian Federation of Anticoagulation Clinics).

    更新日期:2013-03-01 00:00:00

  • Inhibition of monocyte, lymphocyte, and neutrophil adhesion to endothelial cells by human milk oligosaccharides.

    abstract::Excessive leukocyte infiltration causes severe tissue damage in a variety of inflammatory diseases. The initial step in leukocyte extravasation is mediated by selectins and oligosaccharides on their glycoconjugate ligands. Human milk is a rich source of lactose-derived oligosaccharides that are partly absorbed in the ...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH04-01-0055

    authors: Bode L,Kunz C,Muhly-Reinholz M,Mayer K,Seeger W,Rudloff S

    更新日期:2004-12-01 00:00:00

  • Free platelet count and size distribution during C1q inhibition of collagen-induced platelet aggregation.

    abstract::Electronic free platelet counting was more sensitive than turbidimetry to detect collagen-induced platelet activation in human platelet-rich plasma. Purified human C1q exhibited a greater inhibitory effect on collagen-induced platelet aggregation in turbidimetry than free platelet counting. Because the change from sma...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Csako G,Suba EA

    更新日期:1987-08-04 00:00:00

  • Comparative studies of an orally-active factor Xa inhibitor, YM-60828, with other antithrombotic agents in a rat model of arterial thrombosis.

    abstract::We examined the antithrombotic activity of a novel synthetic inhibitor of factor Xa, YM-60828, in an electrically-induced carotid artery thrombosis model in rats. In the first experiment, the antithrombotic activity of YM-60828 after i.v. infusion was compared with those of heparin, darteparin and argatroban. Test dru...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Kawasaki T,Sato K,Sakai Y,Hirayama F,Koshio H,Taniuchi Y,Matsumoto Y

    更新日期:1998-02-01 00:00:00

  • Increased fibrinopeptide A after prothrombin complex concentrates.

    abstract::Prothrombin complex concentrates (PCC) are known to carry a risk of thromboembolism. We have chosen to reassess the problem of detecting in vivo signs of activation of the clotting mechanism by assaying fibrinopeptide A (FpA) after PCC administration in hemophilic patients during bleeding episodes. FpA was significant...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:

    authors: Viganó S,Cattaneo M,Gervasoni W,Mannucci PM

    更新日期:1980-10-31 00:00:00

  • The potential role of platelet microparticles in atherosclerosis.

    abstract::The release of microvesicles ('platelet microparticles', PMPs) by activated platelets has been shown to be an integral part of the thrombotic process. PMPs are believed to mediate many biological processes as they possess various platelet membrane proteins and bioactive lipids. Of note, there is a growing body of evid...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:10.1160/TH05-03-0201

    authors: Tan KT,Lip GY

    更新日期:2005-09-01 00:00:00

  • Tissue factor, protease activated receptors and pathologic heart remodelling.

    abstract::Tissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tiss...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章,评审

    doi:10.1160/TH14-03-0243

    authors: Antoniak S,Sparkenbaugh E,Pawlinski R

    更新日期:2014-11-01 00:00:00

  • The role of CD40 in CD40L- and antibody-mediated platelet activation.

    abstract::Our initial finding that CD40- and CD40 ligand (CD40L)-deficient mice displayed prolonged tail bleeding and platelet function analyzer (PFA-100) closure times prompted us to further investigate the role of the CD40-CD40L dyad in primary hemostasis and platelet function. Recombinant human soluble CD40L (rhsCD40L), chem...

    journal_title:Thrombosis and haemostasis

    pub_type: 杂志文章

    doi:10.1160/TH04-12-0774

    authors: Langer F,Ingersoll SB,Amirkhosravi A,Meyer T,Siddiqui FA,Ahmad S,Walker JM,Amaya M,Desai H,Francis JL

    更新日期:2005-06-01 00:00:00