Abstract:
:Three genotypically suppressible alleles, a1X4, alcA125, and niaD500, are phenotypically suppressed by aminoglycoside antibiotics. Unsuppressible alleles at these loci are unaffected as are known missense mutations at the yA and gdhA loci. This is consistent with the premise that the suppressible mutations are nonsense and that this highly-allele-specific phenotypic suppression can be used to distinguish nonsense from missense mutations of Aspergillus nidulans. Paromomycin and tobramycin are recommended for screening unknown mutations.
journal_name
Biosci Repjournal_title
Bioscience reportsauthors
Martinelli SD,Roberts TJdoi
10.1007/BF01121566subject
Has Abstractpub_date
1983-01-01 00:00:00pages
11-7issue
1eissn
0144-8463issn
1573-4935journal_volume
3pub_type
杂志文章abstract::Perfusion of Langendorff rat hearts with [14C]adenosine yields an acid-insoluble, radioactive product whose concentration falls during ischaemia. The properties of the substance show that it is a polyribonucleotide. It is suggested that it may be mitochondrial poly A acting as a storage form of adenine nucleotides. ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117435
更新日期:1985-01-01 00:00:00
abstract::Alterations in genomic CpG methylation patterns have been found to be associated with cell transformation and neoplasia. Although it is recognized that methylation of CpG residues negatively regulates gene expression, how the various MBPs (methyl-binding proteins) contribute to this process remains elusive. To determi...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20080032
更新日期:2008-12-01 00:00:00
abstract::Inactivation of p53 is one of the most relevant events in human cancer, since it allows transformed cells to escape their own proliferation control and leave them irresponsive to drugs that aim to damage their DNA. When p53 falls, other members of its family may become targets to attack tumoural cells. p73 has shown c...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20150039
更新日期:2015-04-28 00:00:00
abstract::Microparticles (MPs) and miRNAs have been shown to play important roles in coronary artery disease (CAD) by monitoring endothelial dysfunction. The present study aims to investigate the diagnostic value of endothelial MPs (EMPs) and miRNAs (miR-92a or miR-23a) as biomarkers in distinguishing patients with acute myocar...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20170047
更新日期:2017-03-27 00:00:00
abstract::The high proliferation rate of tumor cells demands high energy and metabolites that are sustained by a high glycolytic flux known as the 'Warburg effect'. The activation and further metabolism of glucose is initiated by hexokinase, a focal point of metabolic regulation. The human hexokinase 2 (HK2) is overexpressed in...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20171666
更新日期:2018-02-21 00:00:00
abstract::As a zinc transporter, SLC39A7 (zip7) is vital in intestinal epithelial self-renewal, and recent studies suggested that SLC39A7 was related to cancer progression. Whereas, little is known about the role of SLC39A7 in gastric cancer (GC). In the present study, qRT-PCR analysis demonstrated that SLC39A7 mRNA level was i...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200041
更新日期:2020-02-28 00:00:00
abstract::A possible role for Ca2+ and calmodulin in the action of growth-hormone-releasing factor (GHRF) was investigated. Low extracellular Ca2+ (less than 100 microM), methoxyverapamil, flunarizine, cinnarizine, and Co2+ decreased both basal and GHRF-stimulated growth-hormone secretion, but did not totally inhibit GHRF-stimu...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01116691
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Emerging evidences have indicated that long non-coding RNAs (LncRNAs) play vital roles in cancer development and progression. Previous studies have suggested that overexpression of SPRY4 intronic transcript 1 (SPRY4-IT1) predicates poor prognosis and promotes tumor progress in cervical cancer (CC). However, ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181339
更新日期:2019-06-04 00:00:00
abstract::Background: Single-nucleotide polymorphisms (SNPs) in lncRNAs could be biomarkers for susceptibility to colorectal cancer (CRC), but the association of PCAT1 polymorphisms and CRC susceptibility is yet to be studied. Methods: Five tagSNPs covering the PCAT1 gene were detected through Kompetitive Allele-Specific PCR am...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190708
更新日期:2019-07-12 00:00:00
abstract::HIV-1 infects host cells by sequential interactions of its fusion protein (gp120-gp41) with receptors CD4, CXCR4 and/or CCR5 followed by fusion of viral and host membranes. Studies indicate that additional factors such as receptor density and composition of viral and cellular lipids can dramatically modulate the fusio...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1007/s10540-005-2894-5
更新日期:2005-10-01 00:00:00
abstract::Cell membranes have important functions in many steps of the blood coagulation cascade, including the activation of factor X (FX) by the factor VIIa (FVIIa)-tissue factor (TF) complex (extrinsic Xase). FVIIa shares structural similarity with factor IXa (FIXa) and FXa. FIXa and FXa are regulated by binding to phosphati...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20204077
更新日期:2021-01-22 00:00:00
abstract::Bladder cancer is a common malignant tumour worldwide. Epithelial-mesenchymal transition (EMT)-related biomarkers can be used for early diagnosis and prognosis of cancer patients. To explore, accurate prediction models are essential to the diagnosis and treatment for bladder cancer. In the present study, an EMT-relate...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20203944
更新日期:2021-01-29 00:00:00
abstract::The association between dietary protein intake and ovarian cancer had been inconsistent in the previous epidemiological studies. The aim of the present study was to identify and synthesize all citations evaluating the relationship on ovarian cancer with protein intake. The search included PubMed, Embase, and Web of Sc...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20181857
更新日期:2018-12-11 00:00:00
abstract::A consensus about the prognostic role of NIMA-related kinase 2 (NEK2) expression in various solid tumors has not been made yet. Thus, this meta-analysis aimed to systematically assess the prognostic role of NEK2 expression in patients with solid tumors. The eligible studies were identified through searching PubMed, We...
journal_title:Bioscience reports
pub_type: 杂志文章,meta分析
doi:10.1042/BSR20180618
更新日期:2019-01-18 00:00:00
abstract::Blood pressure (BP) is a known prognostic marker for mortality in patients on maintenance hemodialysis (MHD). However, definition of the BP and its optimal values vary essentially among different MHD populations. Our purpose was to clarify these important clinical parameters in a Chinese MHD cohort. Accordingly, we re...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20200858
更新日期:2020-08-28 00:00:00
abstract::Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disorder. However, studies providing PAH-related gene expression profiles are scarce. To identify hub genes involved in PAH, we investigate two microarray data sets from gene expression omnibus (GEO). A total of 150 differentially expr...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20202346
更新日期:2020-09-30 00:00:00
abstract::An ontogenetic study of the effect of various neurohormones and other activators on adenylate cyclase systems was carried out using cultures of cells from 15-d-old embryonic mouse brain. Dopamine stimulated the enzyme activity at earlier culture ages (i.e. 4 and 10 d) but had little stimulatory effect at later ages (i...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117073
更新日期:1985-07-01 00:00:00
abstract::Fasudil is a derivative of 5-isoquinoline sulfonamide, which is a Rho kinase inhibitor, a wide range of pharmacological effects. Fasudil has been shown to attenuate kidney injury caused by certain substances. In the present study, metabolomic analysis of mouse kidney tissues ultra-performance liquid chromatography/qua...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20192940
更新日期:2019-11-29 00:00:00
abstract:OBJECTIVE:Our aim was to investigate the effect of emodin on intestinal and lung injury induced by acute intestinal injury in rats and explore potential molecular mechanisms. METHODS:Healthy male Sprague-Dawley (SD) rats were randomly divided into five groups (n=10, each group): normal group; saline group; acute intes...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20201605
更新日期:2020-09-30 00:00:00
abstract::Dendritic cells (DCs) present exogenous antigens on major histocompatibility complex (MHC) class I molecules, thereby activating CD8+ T cells, contributing to tumor elimination through a mechanism known as antigen cross-presentation. A variety of factors such as maturation state of DCs, co-stimulatory signals, T-cell ...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1042/BSR20193220
更新日期:2019-10-30 00:00:00
abstract::Previous studies demonstrated that the adaptive response to stressors and inflammatory signals involves the activation of the autonomous [corrected] nervous system. Catecholamines have been shown to modulate the activity of various immune effector cells directly via membrane adrenergic receptors. Here, we investigated...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1023/a:1014768909442
更新日期:2001-10-01 00:00:00
abstract::Background: Previous studies have found that hydrogen sulfide (H2S) has multiple functions such as anti-inflammatory, antioxidative in addition to biological effects among the various organs. Exaggerated proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells (PASMCs) is a key component of va...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20190304
更新日期:2019-07-08 00:00:00
abstract::Chemical and physical stimuli trigger a cutaneous response by first inducing the main epidermal cells, keratinocytes, to produce specific mediators that are responsible for the initiation of skin inflammation. Activation modulates cell communication, namely leucocyte recruitment and blood-to-skin extravasation through...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20070012
更新日期:2008-02-01 00:00:00
abstract::The relative proportions of immunoregulatory T-cell subpopulations defined by OKT monoclonal antibodies are disturbed in chronic lymphocytic leukaemia (CLL) patients (even early mild cases) compared with normal subjects in the same age range. The mean ratio OKT4+:OKT8+ (helper:suppressor/cytotoxic) is reversed from th...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01314213
更新日期:1982-08-01 00:00:00
abstract::This review focuses on the recent developments in the study of drug interactions with biological membranes and membrane-associated proteins using nuclear magnetic resonance (NMR) spectroscopy and other spectroscopic techniques. Emphasis is placed on a class of low-affinity neurological agents as exemplified by volatil...
journal_title:Bioscience reports
pub_type: 杂志文章,评审
doi:10.1023/a:1020182404940
更新日期:2002-04-01 00:00:00
abstract::In India, Sorghum plant allergenicity was reported to be approximately 54.9%. Sorghum bicolor Polcalcin (Sorb PC) was identified as the panallergen but the specificity of this allergen is yet to be characterized. The present study was aimed to characterize the antigenic determinants of Sorb PC that are responsible for...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20191835
更新日期:2019-11-29 00:00:00
abstract::Members of the ADAM (a disintegrin and metalloproteinase) family of proteins possess a multidomain architecture which permits functionalities as adhesion molecules, signalling intermediates and proteolytic enzymes. ADAM8 is found on immune cells and is induced by multiple pro-inflammatory stimuli suggesting a role in ...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20080145
更新日期:2009-08-01 00:00:00
abstract::Neuroblastoma is the most common tumor in children, with a very poor prognosis. It is urgent to identify novel biomarkers to treat neuroblastoma, together with surgery, chemotherapy, and radiation. Human tripartite motif 59 (TRIM59), a member of the TRIM family, has been reported to participate in several human tumors...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1042/BSR20181277
更新日期:2019-01-18 00:00:00
abstract::The kinetics of the fusion process between erythrocyte ghosts, as induced by Sendai virus, were readily revealed by a simple fluorescence procedure previously employed to characterize the fusion of viruses with biological membranes. The method relies on the relief of fluorescence selfquenching of the membrane-inserted...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01114971
更新日期:1986-11-01 00:00:00
abstract::31P NMR studies on microorganisms have been carried out with the cells embedded in agarose gel. The novel use of the gel for the NMR studies has advantages over the usual liquid suspensions in terms of improved reproducibility of data and cell viability, with no net loss of spectral quality. Polyphosphate formation in...
journal_title:Bioscience reports
pub_type: 杂志文章
doi:10.1007/BF01117011
更新日期:1981-02-01 00:00:00