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Phenoxybenzamine is more potent in inactivating alpha 1- than alpha 2-adrenergic receptor binding sites.

Abstract：

:The effects of phenoxybenzamine on alpha 1- and alpha 2-adrenergic receptor binding sites were examined directly using radioligand binding assays of the antagonist drugs [125I]BE 2254 and [3H]rauwolscine, respectively, in homogenates of rat cerebral cortex. Treatment with phenoxybenzamine caused an irreversible, dose-dependent decrease in the density of both alpha 1- and alpha 2-adrenergic receptors. Phenoxybenzamine was approximately 250-fold more potent at decreasing alpha 1-adrenergic receptor density than it was at decreasing alpha 2-adrenergic receptor density.

journal_name

Eur J Pharmacol

journal_title

European journal of pharmacology

authors

Minneman KP

doi

10.1016/0014-2999(83)90458-2

subject

Has Abstract

pub_date

1983-10-14 00:00:00

pages

171-4

issue

1-2

eissn

0014-2999

issn

1879-0712

pii

0014-2999(83)90458-2

journal_volume

94

pub_type

杂志文章

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