Degranulation and appearance of vesicular inclusions in canine C cells after administration of antithyroid drug.

Abstract:

:When stimulated by the feeding of ethylenethiourea for a period of 6 months, dog thyroid glands increased to approximately 30 times their normal size. Not only follicular cells but also C cells had hyperplastic and hypertrophic features, compared with normal controls there was in the C cells a marked decrease in secretory granules immunoreactive for calcitonin. Furthermore, vesicular inclusions of various sizes and dilated nuclear enveloped, which showed a positive immunoreaction for calcitonin, were observed in the C cells. These findings indicate that the antithyroid drug interferes with synthesis of calcitonin by C cells probably by inhibiting the conversion of a larger precursor to calcitonin by C cells, probably by inhibiting the conversion of a larger precursor to calcitonin.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Kameda Y

doi

10.1007/BF00214684

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

315-8

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

225

pub_type

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