Uptake of [3H]ouabain from the cell surface into the lysosomal compartment of HeLa cells.

abstract：:Previous studies indicate that glutamine is a critical requirement for cell proliferation in vitro. We recently showed that depletion of glutamine from the culture medium supporting growing cells significantly reduced the proportion of cells undergoing DNA synthesis. Similarly glutamine depletion significantly reduced...

journal_title：Journal of cellular physiology

authors： Engström W,Zetterberg A

更新日期：1984-08-01 00:00:00

abstract：:When HL60 cells are exposed to 1,25-dihydroxyvitamin D3 (1,25D3), they undergo changes approximating the phenotype of the monocyte. Little is known, however, about the regulation and the mechanisms of this transition. It was previously noted that DNA binding by the Sp1 transcription factor in nuclear extracts of HL60 ...

journal_title：Journal of cellular physiology

authors： Rao J,Zhang F,Donnelly RJ,Spector NL,Studzinski GP

更新日期：1998-05-01 00:00:00

abstract：:Retinoic acid (RA) reduced growth, fibronectin, and retinoic acid receptor (RAR alpha) in NIH 3T3 cells but not in cells transformed by the Ha-ras oncogene. RA lowered RAR alpha transcript and protein, increased RAR beta transcripts, and had no effect on RAR gamma. H-ras transformation downregulated RAR expression and...

journal_title：Journal of cellular physiology

authors： De Luca LM,Scita G,Takatsuka J

更新日期：1997-11-01 00:00:00

abstract：:The human chronic myeloid leukemia cell line K562 acquires several megakaryoblastoid features when cultured in the presence of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). We observed strongly increased secretion of several proteins into the culture media of K562 cells within a few hours of TPA trea...

journal_title：Journal of cellular physiology

authors： Alitalo R,Andersson LC,Tapiovaara H,Sistonen L,Vaheri A,Stephens R

更新日期：1989-07-01 00:00:00

abstract：:Insufficient invasion ability of trophoblasts might be associated with the development of recurrent miscarriage (RM). Ubiquitin-specific protease 25 (USP25) can regulate the processes of invasion and migration in different types of cancer cells. However, the effect of USP25 on trophoblasts and its roles in the develop...

journal_title：Journal of cellular physiology

authors： Ding J,Cheng Y,Zhang Y,Liao S,Yin T,Yang J

更新日期：2019-11-01 00:00:00

abstract：:The serine protease thrombin has been proposed to be involved in neuromuscular plasticity. Its specific receptor "protease activated receptor-1" (PAR-1), a G protein-coupled receptor, has been shown to be expressed in myoblasts but not after fusion (Suidan et al., 1996 J Biol Chem 271:29162-29169). In the present work...

journal_title：Journal of cellular physiology

authors： Chevessier F,Hantaï D,Verdière-Sahuqué M

更新日期：2001-11-01 00:00:00

abstract：:The eukaryotic translation initiation factor 5A (eIF5A) contains a special amino acid residue named hypusine that is required for its activity, being produced by a post-translational modification using spermidine as substrate. Stem cells from rat skeletal muscles (satellite cells) were submitted to differentiation and...

journal_title：Journal of cellular physiology

authors： Luchessi AD,Cambiaghi TD,Hirabara SM,Lambertucci RH,Silveira LR,Baptista IL,Moriscot AS,Costa-Neto CM,Curi R

更新日期：2009-03-01 00:00:00

abstract：:Despite remarkable progress in polychemotherapy protocols, pediatric B-cell acute lymphoblastic leukemia (B-ALL) remains fatal in around 20% of cases. Hence, novel targeted therapies are needed for patients with poor prognosis. Glucocorticoids (GCs) are drugs commonly administrated for B-ALL treatment. Activation of t...

journal_title：Journal of cellular physiology

authors： Evangelisti C,Cappellini A,Oliveira M,Fragoso R,Barata JT,Bertaina A,Locatelli F,Simioni C,Neri LM,Chiarini F,Lonetti A,Buontempo F,Orsini E,Pession A,Manzoli L,Martelli AM,Evangelisti C

更新日期：2018-03-01 00:00:00

abstract：:Osteosarcoma is the most common malignant primary bone tumor in children and adolescents. The clinical outcome for osteosarcoma remains discouraging despite aggressive surgery and intensive radiotherapy and chemotherapy regimens. Thus, novel therapeutic approaches are needed. Previously, we have shown that inorganic p...

journal_title：Journal of cellular physiology

authors： Spina A,Sorvillo L,Di Maiolo F,Esposito A,D'Auria R,Di Gesto D,Chiosi E,Naviglio S

更新日期：2013-01-01 00:00:00

abstract：:We have investigated the characteristics of a transport system in HeLa cells, which turned out to be very similar to a previously described Na+, K+, 2Cl- -cotransport system. For further understanding about the physiological role of the cotransporter, we have mutagenized HeLa cells and selected progeny cells for growt...

journal_title：Journal of cellular physiology

authors： Kort JJ,Koch G

更新日期：1989-10-01 00:00:00

abstract：:Nucleoside transporter proteins are specialized proteins that mediate the transport of nucleosides and nucleoside analog drugs across the plasma membrane. The human equilibrative nucleoside transporter 1 (hENT1) is a member of these proteins and mediates cellular entry of gemcitabine, cytarabine, and fludarabine. The ...

journal_title：Journal of cellular physiology

authors： Santini D,Vincenzi B,Fratto ME,Perrone G,Lai R,Catalano V,Cass C,Ruffini PA,Spoto C,Muretto P,Rizzo S,Muda AO,Mackey JR,Russo A,Tonini G,Graziano F

更新日期：2010-05-01 00:00:00

abstract：:Apoptosis is also known as programmed cell death. Apoptosis plays an essential role in maintaining normal tissue and cell physiology in multicellular organisms. Clearance of aberrant or pre-cancerous cells occurs through the induction of apoptosis. It has been reported that many tumors and tumor cell lines have dysfun...

journal_title：Journal of cellular physiology

authors： Holmes WF,Soprano DR,Soprano KJ

更新日期：2004-06-01 00:00:00

abstract：:The human neuroblastoma cell line SK-N-BE, after incubation with 10 microM retinoic acid (RA) or 20 nM phorbol 12-myristate 13-acetate (PMA), underwent biochemical and morphological signs of differentiation within 10-14 days. In parallel, SK-N-BE cells produced significantly higher amounts of nitric oxide (NO) in comp...

journal_title：Journal of cellular physiology

authors： Ghigo D,Priotto C,Migliorino D,Geromin D,Franchino C,Todde R,Costamagna C,Pescarmona G,Bosia A

更新日期：1998-01-01 00:00:00

abstract：:Progesterone is an endogenous immunomodulator and can suppress T-cell activation during pregnancy. We have previously shown that the non-genomic effects of progesterone, especially acidification, are exerted via plasma membrane sites and suppress cellular genomic responses to mitogens. This study aimed to show that ac...

journal_title：Journal of cellular physiology

authors： Chien EJ,Liao CF,Chang CP,Pu HF,Lu LM,Shie MC,Hsieh DJ,Hsu MT

更新日期：2007-05-01 00:00:00

abstract：:Wnt1-inducible signaling pathway protein-1 (WISP1) is a Cyr61/CTGF/NOV (CCN) family matricellular protein involved in adipogenesis and low-grade inflammation in obesity. However, the roles of WISP1 in hepatic steatosis and insulin resistance in skeletal muscle remain elusive. Mouse primary hepatocytes and differentiat...

journal_title：Journal of cellular physiology

authors： Jung TW,Kang C,Goh J,Chae SI,Kim HC,Lee TJ,Abd El-Aty AM,Jeong JH

更新日期：2018-08-01 00:00:00

abstract：:Testicular cancer is the most common solid malignancy among young men. We downloaded data of testicular cancer patients from The Cancer Genome Atlas database to find novel genes in the testicular cancer microenviroment based on ESTIMATE algorithm-derived immune scores. A total of 156 cases of testicular cancer were in...

journal_title：Journal of cellular physiology

authors： Ke ZB,Wu YP,Huang P,Hou J,Chen YH,Dong RN,Lin F,Wei Y,Xue XY,Ng CF,Xu N

更新日期：2021-01-01 00:00:00

abstract：:The tuftelin protein isoforms undergo post-translation modifications, and are ubiquitously expressed in various tissues in embryos, adults, and tumors. Developmental and pathological studies suggested an apparent correlation between oxygen deprivation and tuftelin expression. The aim of the study was therefore to inve...

journal_title：Journal of cellular physiology

authors： Leiser Y,Silverstein N,Blumenfeld A,Shilo D,Haze A,Rosenfeld E,Shay B,Tabakman R,Lecht S,Lazarovici P,Deutsch D

更新日期：2011-01-01 00:00:00

abstract：:Cadmium (Cd) is a toxic metal with multiple effects on cell signaling and cell death. We studied the effects of Cd(2+) on quiescent mouse mesangial cells in serum-free conditions. Cadmium induces cell death over 6 h through annexin V+ states without or with causing uptake of propidium iodide, termed apoptotic and apop...

journal_title：Journal of cellular physiology

authors： Liu Y,Templeton DM

更新日期：2008-11-01 00:00:00

abstract：:Phenotypically different osteoclasts may be generated from different subsets of precursors. To what extent the formation of these osteoclasts is influenced or mediated by the inflammatory cytokine TNF-α, is unknown and was investigated in this study. The osteoclast precursors early blasts (CD31hi Ly-6C- ), myeloid bla...

journal_title：Journal of cellular physiology

authors： Cao Y,Jansen IDC,Sprangers S,de Vries TJ,Everts V

更新日期：2017-12-01 00:00:00

abstract：:The vagina provides a characteristic low-Na+ and low-pH fluid microenvironment that is considered generally protective. Previous studies have shown that various types of epithelial cells harbor the capacity of intracellular pH (pHi) regulation. However, it remains elusive whether vaginal epithelium could actively regu...

journal_title：Journal of cellular physiology

authors： Zhang YL,Feng JC,Ke LJ,Xu JW,Huang ZX,Huang J,Zhu YX,Zhou WL

更新日期：2019-01-29 00:00:00

abstract：:Mouse heptoma cells that secrete large amounts of alpha-fetoprotein (AFP) and albumin have been crossed with rat hepatoma cells that secret only albumin, and in relatively small amounts, to investigate the influence of each parental genome upon the expression of serum proteins. All of the ten independent hybrid clones...

journal_title：Journal of cellular physiology

authors： Cassio D,Hassoux R,Dupiers M,Uriel J,Weiss MC

更新日期：1980-09-01 00:00:00

abstract：:The biological actions of retinoids are mediated by nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs). We have recently reported that decreased expression of RARα and RXRα has an important role in high glucose (HG)-induced cardiomyocyte apoptosis. However, the regulatory mechanisms of HG effects o...

journal_title：Journal of cellular physiology

authors： Singh AB,Guleria RS,Nizamutdinova IT,Baker KM,Pan J

更新日期：2012-06-01 00:00:00

abstract：:Ganoderma lucidum is used in traditional Chinese medicine to prevent or treat a variety of diseases, including cardiovascular disorders. We previously demonstrated that a glucan-containing extract of Reishi polysaccharides (EORP) has the potent anti-inflammatory action of reducing ICAM-1 expression in lipopolysacchari...

journal_title：Journal of cellular physiology

authors： Wang SH,Liang CJ,Weng YW,Chen YH,Hsu HY,Chien HF,Tsai JS,Tseng YC,Li CY,Chen YL

更新日期：2012-08-01 00:00:00

abstract：:The effects of the polyamines putrescine (PUT), spermidine (SPD), and spermidine (SPM) on the secretion of plasminogen activator (PA) and plasminogen activator inhibitor (PAI) were evaluated using cultured bovine aortic endothelial cells. All three polyamines enhanced PA secretion in a time- and dose-dependent manner,...

journal_title：Journal of cellular physiology

authors： Kuo BS,Korner G,Dryjski M,Bjornsson TD

更新日期：1988-10-01 00:00:00

abstract：:Tfcp2l1 is a transcription factor critical for mouse embryonic stem cell (mESC) maintenance. However, its role in human ESCs (hESCs) remains unclear. Here, we investigated the role of Tfcp2l1 in controlling hESC activity and showed that Tfcp2l1 is functionally important in the maintenance of hESC identity. Tfcp2l1 exp...

journal_title：Journal of cellular physiology

authors： Sun H,You Y,Guo M,Wang X,Zhang Y,Ye S

更新日期：2018-09-01 00:00:00

abstract：:Estrogen has been shown to protect osteoblastic cells from apoptosis. Similarly, estrogen treatment preceding heat shock elevates heat shock protein 27 (hsp27) expression and increases thermoresistance in the murine estrogen receptor-transformed SMER14 osteoblastic cell line. Forced expression of hsp27 expression in o...

journal_title：Journal of cellular physiology

authors： Cooper LF,Tiffee JC,Griffin JP,Hamano H,Guo Z

更新日期：2000-12-01 00:00:00

abstract：:Incubation of alveolar macrophages or hepatocytes in media in which Na+ is replaced by K+ ("isotonic-K buffer") inhibited the movement of internalized ligand from late endosomes to lysosomes (Ward et al.: Journal of Cell Biology 110:1013-1022, 1990). In this study we investigate the mechanism responsible for the isoto...

journal_title：Journal of cellular physiology

authors： Ward DM,Hackenyos DP,Davis-Kaplan S,Kaplan J

更新日期：1990-12-01 00:00:00

abstract：:It was shown previously that mouse bone marrow cells transformed by simian virus 40 (SV40) show a reversible cell density-dependent phenotypic transition between the nonmacrophage (rapidly growing) and the macrophage (stationary) states; cells in low-density cultures are in the growing phase, express SV40 T antigen st...

journal_title：Journal of cellular physiology

authors： Tanigawa T,Takayama H,Takagi A,Kimura G

更新日期：1983-09-01 00:00:00

abstract：:Differentiation commitment events are essential for the initiation of hemopoiesis and, in one form or another, occur continuously during adult hemopoiesis. The most studied type of differentiation commitment decision a hemopoietic cell can make involves the alternative choice of self-renewal versus the formation of pr...

journal_title：Journal of cellular physiology

authors： Metcalf D,Nicola NA,Robb L

更新日期：1997-11-01 00:00:00

abstract：:Liver fibrosis is a reversible wound-healing response that occurs after liver injury. NADPH oxidases (NOXs) and reactive oxygen species (ROS) which are expressed in hepatocytes (HCs), hepatic stellate cells (HSCs), and Kupffer cells (KCs) play an important role in the development of hepatic fibrosis. In in vitro studi...

journal_title：Journal of cellular physiology

authors： Gan D,Zhang W,Huang C,Chen J,He W,Wang A,Li B,Zhu X

更新日期：2018-10-01 00:00:00