Abstract:
:The secondary structure of an adenovirus associated low molecular weight RNA (VAI-RNA) has been studied by partial digestion with T1-RNase and S1-endonuclease followed by T1-fingerprint analysis. The empirical secondary structure has been compared with two computer generated models based on minimal free energy of the structure. The results suggest that VAI-RNA in solution has a compact structure with a free energy of around -60 kcal with two stems and four bulge regions. The implication of this structure for the function of VAI-RNA is discussed.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Monstein HJ,Philipson Ldoi
10.1093/nar/9.17.4239subject
Has Abstractpub_date
1981-09-11 00:00:00pages
4239-50issue
17eissn
0305-1048issn
1362-4962journal_volume
9pub_type
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