The conformation of adenovirus VAI-RNA in solution.

Abstract:

:The secondary structure of an adenovirus associated low molecular weight RNA (VAI-RNA) has been studied by partial digestion with T1-RNase and S1-endonuclease followed by T1-fingerprint analysis. The empirical secondary structure has been compared with two computer generated models based on minimal free energy of the structure. The results suggest that VAI-RNA in solution has a compact structure with a free energy of around -60 kcal with two stems and four bulge regions. The implication of this structure for the function of VAI-RNA is discussed.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Monstein HJ,Philipson L

doi

10.1093/nar/9.17.4239

subject

Has Abstract

pub_date

1981-09-11 00:00:00

pages

4239-50

issue

17

eissn

0305-1048

issn

1362-4962

journal_volume

9

pub_type

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