Immunocytochemistry of luteinizing hormone-releasing hormone, vasopressin, and corticotropin following deafferentation of the basal hypothalamus of the male rat brain.

Abstract:

:Luteinizing hormones-releasing hormone (LHRH), vasopressin, and corticotropin systems were examined by immunocytochemical methods in male rats 2 to 20 days after deafferentation of the basal hypothalamus. Axonal degeneration of the vasopressin system (whose perikarya lie rostral to the island) and the corticotropin system (whose perikarya lie within the island) was examined and compared with the response of the LHRH system. Vasopressin immunoreactive staining was absent in the internal zone of the median eminence 10 and 20 days after deafferentation. Disruption of the efferent projections of the opiocortin system caused the loss of almost all fiber staining outside the island by the 5th postoperative day. LHRH staining in the median eminence was modestly reduced in 5 days, considerably reduced in 10 days and negligible 20 days after deafferentation. At 10 and/or 20 days after deafferentation densely stained fibers of all three systems were observed on both sides of the cut. Invasive vasopressinergic fibers reached the lateral median eminence by the 20th postoperative day. This study reports on the response of three neuropeptide systems after complete deafferentation and demonstrates that regeneration can occur across the knife cut.

journal_name

Cell Tissue Res

journal_title

Cell and tissue research

authors

Scott PM,Knigge KM

doi

10.1007/BF00210157

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

393-402

issue

2

eissn

0302-766X

issn

1432-0878

journal_volume

219

pub_type

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