Abstract:
:The prothrombin-converting activity of Factor Xa was enhanced by thrombin-stimulated Factor V-deficient platelets and supplementary extraneous Factor Va, and also by thrombin-stimulated normal human platelets. Both extraneous Factor Va and intra-platelet Factor Va were equally inactivated by a gamma-carboxyglutamic acid-containing plasma protease, activated protein C. However, a relatively larger amount of activated protein C was required for efficient inactivation of platelet-associated Factor Va as compared with the amount of activated protein C needed for inactivation of phospholipid vesicle-associated Factor Va. Protein S, another gamma-carboxyglutamic acid-containing plasma protein, increased the rate of the inactivation of platelet-associated Factor Va about 25-fold. This stimulating effect was observed only slightly with the thrombin-modified protein S. Thus, it was concluded that protein S is essential for the process of inactivation of platelet-associated Factor Va by activated protein C.
journal_name
J Biochemjournal_title
Journal of biochemistryauthors
Suzuki K,Nishioka J,Matsuda M,Murayama H,Hashimoto Sdoi
10.1093/oxfordjournals.jbchem.a134857subject
Has Abstractpub_date
1984-08-01 00:00:00pages
455-60issue
2eissn
0021-924Xissn
1756-2651journal_volume
96pub_type
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更新日期:1991-04-01 00:00:00
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更新日期:2007-05-01 00:00:00
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更新日期:1995-11-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
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更新日期:1995-11-01 00:00:00
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更新日期:1995-11-01 00:00:00
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journal_title:Journal of biochemistry
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更新日期:1993-02-01 00:00:00
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更新日期:2002-04-01 00:00:00
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journal_title:Journal of biochemistry
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更新日期:2014-12-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a021795
更新日期:1997-09-01 00:00:00
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更新日期:2017-03-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章,评审
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更新日期:2013-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a021318
更新日期:1996-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-11-01 00:00:00
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更新日期:2020-11-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
doi:10.1093/oxfordjournals.jbchem.a132537
更新日期:1979-08-01 00:00:00
abstract::Homoserine O-acetyltransferase [EC 2.3.1.31] partially purified from Brevibacterium flavum was found to be specifically inhibited by the metabolic end products methionine and S-adenosylmethionine only when the enzymatic reaction was performed in the presence of cysteine or dithiothreitol, or after the preincubation of...
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pub_type: 杂志文章
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更新日期:1981-05-01 00:00:00
abstract::We isolated the human arylhydrocarbon receptor (AhR) cDNA from a human lung cDNA library, by using mouse AhR cDNA as a labeled probe. The nucleotide sequence of cloned human AhR cDNA is identical to the previously reported human AhR sequence [Dolwick et al. (1993), Mol. Pharmacol. 44, 911-917] from cell line HepG2. Th...
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更新日期:1994-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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journal_title:Journal of biochemistry
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更新日期:2010-02-01 00:00:00
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journal_title:Journal of biochemistry
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更新日期:2005-06-01 00:00:00
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journal_title:Journal of biochemistry
pub_type: 杂志文章
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更新日期:1978-05-01 00:00:00