Abstract:
:Data from the United Kingdom on childhood leukaemia and childhood cancer in twins and from the United States on leukaemia in twins are analysed by a new method. The method distinguishes determinants occurring before the stage of pregnancy corresponding with the cleavage of MZ pairs, from determinants occurring after this point. It derives estimates of the frequencies of each class of determinant. Different aetiological models are characterised by particular combinations of frequencies, and can thus be identified. The results of the analysis suggest that the major determinants of childhood leukaemia, and possibly of the solid cancers as well, operate before the time of cleavage. They operate either on the early zygote or its component germ cells. These early determinants are not, however, sufficient causes and require combination with postcleavage determinants, which subsequently occur in about a quarter of all children, before leukaemia can ensue.
journal_name
J Epidemiol Community Healthjournal_title
Journal of epidemiology and community healthauthors
Knox EG,Marshall T,Barling Rdoi
10.1136/jech.38.1.12subject
Has Abstractpub_date
1984-03-01 00:00:00pages
12-6issue
1eissn
0143-005Xissn
1470-2738journal_volume
38pub_type
杂志文章abstract::Systematic screening of death certificates referable to residents of two health districts covered by a psychiatric case register allows the study of excess mortality in unselected psychiatric patients from a defined area of known population. Deaths among the case register patients exceeded those expected by 80%; the r...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.42.3.286
更新日期:1988-09-01 00:00:00
abstract::In epidemiological studies the diagnosis of a past history of myocardial infarction is made from the answer to a single question: "Have you ever had a severe pain across the front of your chest lasting for half an hour or more?" Two additional questions, which form an optional part of the London School of Hygiene and ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.42.2.116
更新日期:1988-06-01 00:00:00
abstract:STUDY OBJECTIVE:The aim was to identify any social class differences in health and care in the year before death emerging from a wider study of life before death. DESIGN AND SETTING:Data were collected at interviews, mainly of close relatives, with those who knew most about the people's lives in the year before they d...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.46.1.54
更新日期:1992-02-01 00:00:00
abstract:STUDY OBJECTIVE:In many countries, cancer registries cover only a small part of the national population. Cancer incidence for the rest of the country has therefore to be estimated. This can be done from mortality data using the relation between incidence and mortality observed in the cancer registry areas. Such an appr...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.53.9.558
更新日期:1999-09-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the completeness and accuracy of notification of cancers by the National Health Service Central Register (NHSCR) for England and Wales. DESIGN:Comparison of 720 cancer registrations ascertained from NHSCR up to May 1999 with those ascertained for the same cohort from six other sources and a p...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.55.6.414
更新日期:2001-06-01 00:00:00
abstract::Ovarian cancer is one of the most common gynaecological neoplasms, especially in industrialised countries. The aetiology of the disease is not well understood, except that inherited mutations in the breast cancer genes BRCA-1 and BRCA-2 account for up to 10% of all cases, and child-bearing, oral contraceptive use and ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
doi:10.1136/jech.2006.047894
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Alcohol policies around the world seek to delay the initiation of drinking. This is partly based on the influential idea that earlier initiation is likely to cause adult alcohol problems. This study synthesises robust evidence for this proposition. METHODS:Systematic review of prospective cohort studies in ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,meta分析,评审
doi:10.1136/jech-2013-203402
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Over the last decades of the 20th century, a widening of the gap in death rates between upper and lower socioeconomic groups has been reported for many European countries. For most countries, it is unknown whether this widening has continued into the first decade of the 21st century. METHODS:We collected an...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2014-204319
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:To examine the extent to which the justice of decision-making procedures and interpersonal relationships is associated with smoking. SETTING:10 municipalities and 21 hospitals in Finland. DESIGN AND PARTICIPANTS:Cross-sectional data derived from the Finnish Public Sector Study were analysed with logistic re...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2007.061739
更新日期:2007-05-01 00:00:00
abstract::This study was conducted at the paediatric emergency department of a tertiary care teaching and referral hospital in Kabul, Afghanistan to assess the morbidity and mortality pattern of illness in paediatric population. Afghanistan has one of the highest infant mortality rates in the world, and there is complete breakd...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2005.040147
更新日期:2006-01-01 00:00:00
abstract::Eight hundred and ninety-nine men were studied, aged 16-65 inclusive, who underwent an elective inguinal herniorrhaphy during 1970 and 1971 in eight hospitals in Wessex, and under nine consultant surgeons. There was a significant variation in postoperative inpatient stay and total sickness absence between hospitals an...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.33.2.121
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND:Active ageing is a key to healthy ageing; shopping behaviour is an economically relevant activity of the elderly. METHODS:Analysis was based on the NAHSIT 1999-2000 dataset. A total of 1841 representative free-living elderly Taiwanese people were selected and information included demographics, socioeconomic...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2010.126698
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:Organisational justice has been proposed as a new way to examine the impact of psychosocial work environment on employee health. This article studied the justice of interpersonal treatment by supervisors (the relational component of organisational justice) as a predictor of health. DESIGN:Prospective cohort ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2003.019026
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:In the context of fiscal austerity in many European welfare states, policy innovation often takes the form of 'social investment', a contested set of policies aimed at strengthening labour markets. Social investment policies include employment subsidies, skills training and job-finding services, early childh...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2018-211283
更新日期:2019-03-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate the association of sexual problems with social, physical, and psychological problems. DESIGN:An anonymous postal questionnaire survey. SETTING:Four general practices in England. PARTICIPANTS:789 men and 979 women responding to a questionnaire sent to a stratified random sample of the a...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.53.3.144
更新日期:1999-03-01 00:00:00
abstract::Five-year age-specific incidence rates were shown to produce small but systematic errors in the calculation of the expected number of tumours in a hypothetical but realistic study population. Underestimates occurred at younger ages (under 55) and overestimates at older ages, with a small overestimate (0.22%) overall. ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.35.2.146
更新日期:1981-06-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to quantify mortality after elective repair of abdominal aortic aneurysm (AAA) in England, and to compare English case fatality rates (CFRs) with those reported in the literature. PATIENTS AND METHODS:English Hospital Episode Statistics (HES) for the financial years 1998/9 to 200...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
doi:10.1136/jech.2006.047001
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Research on inequalities in health has shown a strong association between the lack of standard of living (defined as material deprivation) and self-rated health (SRH). In this study, we sought to further examine this association in a trend analysis of relative and absolute inequalities in SRH as defined by m...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2015-205948
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Children are particularly vulnerable to the effects of extreme temperatures. OBJECTIVE:To examine the relationship between extreme temperatures and paediatric emergency department admissions (EDAs) in Brisbane, Australia, during 2003-2009. METHODS:A quasi-Poisson generalised linear model combined with a di...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2013-202725
更新日期:2014-04-01 00:00:00
abstract:STUDY OBJECTIVE:The aim of this paper is to systematically review and analyse the validity and reliability of Antonovsky's life orientation questionnaire/sense of coherence scale (SOC). DESIGN:The study is descriptive and analytical with a systematic integration of the contemporary knowledge base on the salutogenic re...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
doi:10.1136/jech.2003.018085
更新日期:2005-06-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate a community wide outbreak of hepatitis A (HA). DESIGN:Description of the outbreak, with a case-control study to assess transmission. SETTING:A Florida county, USA, 1988-9. SUBJECTS:A total of 311 cases of HA. MEASUREMENTS AND MAIN RESULTS:A 13 month outbreak of HA is described. Most o...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.47.4.269
更新日期:1993-08-01 00:00:00
abstract::The Ottawa Charter has exerted a great deal of influence on the public health debate and on health promotion practices over the last 25 years. The Charter shifted the main focus from individual risk behaviours to social determinants of health, and introduced innovative strategies such as participatory processes and em...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2010.110437
更新日期:2010-06-01 00:00:00
abstract:AIM:To systematically review the association between intergenerational social mobility and leisure-time physical activity (LTPA) in adulthood, in order to assess all published evidence relating to the hypothesis that adults socially mobile between childhood and adulthood will have different levels of LTPA than those in...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
doi:10.1136/jech-2016-208052
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:This paper aims to show that, compared with young women, there is an apparent discrepancy in the reported sexual behaviour of young men and records of their fatherhood. DESIGN:The data come from four studies of the sexual behaviour of young people in various parts of Britain between 1960 and 1990 and from st...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.48.1.52
更新日期:1994-02-01 00:00:00
abstract:OBJECTIVE:To investigate diagnosis-specific sick leave as a risk marker for subsequent disability pension. DESIGN:A prospective population based cohort study. Exposure to a new medically certified sick leave episode of more than seven days by diagnosis during 1985 was examined in relation to incident cause-specific di...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2006.055426
更新日期:2007-10-01 00:00:00
abstract:INTRODUCTION:Health inequalities can be observed in early life as unfavourable birth outcomes. Evidence indicates that neighbourhood socioeconomic circumstances influence health. However, studies looking into temporal trends in inequalities in birth outcomes including neighbourhood socioeconomic conditions are scarce. ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2019-213162
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:The fall in the prevalence of left handedness with age has been attributed to either premature mortality or a cohort effect of forced dextrality. Evidence for forced dextrality was sought to differentiate between these competing theories. DESIGN:6097 Edinburgh handedness inventories were used to calculate l...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.52.1.41
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Much of the UK government's 1999 report on teenage pregnancy was by necessity based on rather old or non-longitudinal research. AIM:To examine the associations between risk factors identified in the report and pregnancy at or before age 16 years among young women and partners of young men using the more rec...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,随机对照试验
doi:10.1136/jech.2005.040865
更新日期:2007-01-01 00:00:00
abstract:STUDY OBJECTIVE:Understanding causes of variation in birth weight has been limited by lack of sufficient sets of data that include paternal birth weight. The objective was to estimate risks of low birth weight dependent on parental birth weights and to estimate father-mother-offspring correlations for birth weight to e...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.55.12.873
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:A reduction in sex ratio at live birth has been proposed as a sentinel health indicator that can be used to monitor the health of populations. OBJECTIVE:To test the hypothesis that a lower sex ratio is associated with adverse national population health using the prevalences of HIV and tuberculosis as measur...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2011-200744
更新日期:2013-04-01 00:00:00