Abstract:
:Neuroleptic-induced tardive dyskinesia (TD) that persists for 1 year or more following withdrawal of neuroleptics is usually said to be permanent. Early spontaneous remissions have been well described but most such remissions occurred within the first few months following neuroleptic withdrawal, and no published studies have followed patients for more than 2 years to evaluate permanence of remission. Over the last 12 years, we studied six patients with TD who, on prolonged follow-up, were found to have complete remission of their abnormal movements after a neuroleptic-free period of more than 2 years (2 1/2-5 years). All six patients were 61 years old or younger when their TD was diagnosed and their neuroleptics withdrawn. In five of the patients, remission occurred while the patients were not taking medication for the movements, while one patient had been on long-term, high-dose (2 mg/day) reserpine therapy for more than 3 years. The incidence of late remission of TD is not known and cannot be estimated from these selected patients, but these cases demonstrate that persistence of abnormal movements of TD for 2 or more years following neuroleptic withdrawal does not imply permanence in all patients. We suggest that TD be considered a persistent rather than an invariably permanent disorder.
journal_name
Clin Neuropharmacoljournal_title
Clinical neuropharmacologyauthors
Klawans HL,Tanner CM,Barr Adoi
10.1097/00002826-198406000-00006subject
Has Abstractpub_date
1984-01-01 00:00:00pages
153-9issue
2eissn
0362-5664issn
1537-162Xjournal_volume
7pub_type
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journal_title:Clinical neuropharmacology
pub_type: 杂志文章
doi:10.1097/WNF.0000000000000404
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
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journal_title:Clinical neuropharmacology
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