The effect of alpha-difluromethylornithine and tartaric acid on sperm count, seminal gamma GT, FSH, LH, testosterone and steroid excretion in patients with chronic prostatitis.

Abstract:

:The inactivation of ornithine decarboxylase, a polyamine biosynthetic enzyme, by alpha-difluoromethylornithine (alpha-DFMO) was studied in patients with chronic non-suppurative prostatitis. Partial clinical response and remission of gross hematospermia were observed after 18 g/day alpha-DFMO, when administered orally for 1 month. The determination of gamma-glutamyltransferase, LH, Testosterone in semen and also of sperm motility and vitality appeared distinctly changed in alpha-DFMO treated patients, indicating a significant effect on the activity of the prostate. -- A 16% decrease of hematocrit and hemoglobin in 2 out of 10 patients was reversible 2 months after stopping the therapy. The placebo, which was identified mainly as tartaric acid after termination of the study showed similar clinical response and change of seminal parameters. The modulation of sperm count, seminal gamma GT, LH and testosterone was correlated to the known inhibition of prostatic acid phosphatase by tartaric acid in vitro.

journal_name

Andrologia

journal_title

Andrologia

authors

Dunzendorfer U,Feller H

doi

10.1111/j.1439-0272.1981.tb00014.x

subject

Has Abstract

pub_date

1981-03-01 00:00:00

pages

100-7

issue

2

eissn

0303-4569

issn

1439-0272

journal_volume

13

pub_type

杂志文章
  • Safety aspects of androgen treatment with 5alpha-dihydrotestosterone.

    abstract::5alpha-Dihydrotestosterone (DHT), the most powerful naturally occurring androgen, is commercially available since 1982 as a gel. In view of its considerably higher biopotency (three to six times) than of testosterone, side effects, particularly on the main target organ of androgens, the prostate, are anticipated. In f...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1439-0272.2007.00786.x

    authors: Sakhri S,Gooren LJ

    更新日期:2007-12-01 00:00:00

  • Evaluation of clinical effects of microsurgical subinguinal varicocelectomy with and without testicular delivery.

    abstract::The aim of this study was to access whether microsurgical subinguinal varicocelectomy (MSV) with testicular delivery has a better therapeutic effect than MSV without testicular delivery, including semen quality, serum testosterone (T) level and International Index of Erectile Function (IIEF)-5 score in infertility mal...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13605

    authors: Jin L,Yao Q,Wu S,Dai G,Xiang H,Liu X,Xue B

    更新日期:2020-07-01 00:00:00

  • Significance of CFTR gene mutations in patients with congenital aplasia of vas deferens with special regard to renal aplasia.

    abstract::Between 1994 and 2010, a total of 123 patients with obstructive azoospermia due to aplasia of vas deferens (CAVD) were surgically treated. In 110 patients, the condition was bilateral (CBAVD), 13 men had unilateral aplasia (CUAVD), and 10 patients additionally had aplasia of one kidney. All patients underwent CFTR gen...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2012.01281.x

    authors: Schwarzer JU,Schwarz M

    更新日期:2012-10-01 00:00:00

  • Efficacy of tamoxifen and l-carnitine on sperm ultrastructure and seminal oxidative stress in patients with idiopathic oligoasthenoteratozoospermia.

    abstract::Idiopathic oligoathenoteratozoospermia (iOAT) is a common finding in the evaluation of male infertility. Oxidative stress (OS) may underlie its pathology. Tamoxifen and l-carnitine are used to treat idiopathic male infertility. The aim of this work was to detect the efficacy of tamoxifen and l-carnitine on sperm param...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12333

    authors: Nada EA,El Taieb MA,Ibrahim HM,Al Saied AE

    更新日期:2015-09-01 00:00:00

  • Azoospermia and maturation arrest: malfunction of valves in erect poster of humans leads to hypoxia in sperm production site.

    abstract::Maturation arrest (MA) of spermatogenesis is diagnosed on histology as interruption of spermatogenesis before the final stage without impairment of Sertoli or Leydig cells. It is considered a condition of irreversible or absolute infertility. Varicocele, which represents impairment in the testicular venous drainage sy...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2010.01083.x

    authors: Gat Y,Gornish M,Chakraborty J,Perlow A,Levinger U,Pasqualotto F

    更新日期:2010-12-01 00:00:00

  • The value of epididymal protease inhibitor in differential diagnosis between obstructive azoospermia and non-obstructive azoospermia.

    abstract::There are no efficient and noninvasive clinical tests to distinguish between obstructive azoospermia (OA) and non-obstructive azoospermia (NOA). Epididymal protease inhibitor (Eppin) protein is secreted specifically by testes and epididymides in male reproductive system. It does not exist in seminal plasma of patients...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2011.01085.x

    authors: Liu B,Su S,Wang P,Niu X,Yang X,Zhang W,Wang Z,Wang X

    更新日期:2011-10-01 00:00:00

  • Antioxidant effects of N-acetylcysteine on the male reproductive system: A systematic review.

    abstract::This study aimed to evaluate the effect of N-acetyl cysteine on the male reproductive system and consensus and classification of data found from previous studies. It is undeniable that N-acetyl cysteine as a powerful antioxidant compound can medicate many diseases such as cardiovascular, kidney, liver and reproductive...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.13898

    authors: Ghafarizadeh A,Malmir M,Naderi Noreini S,Faraji T

    更新日期:2021-02-01 00:00:00

  • Implications of prostate inflammation on male fertility.

    abstract::The prostate is the seat of three major causes of morbidity: benign prostatic hyperplasia, prostate cancer and prostatitis, three conditions in which inflammation has been implicated. A state of inflammation of the prostate gland, originally incited by an infection, an autoimmune response, a neurogenic stimulus or ano...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.13093

    authors: Motrich RD,Salazar FC,Breser ML,Mackern-Oberti JP,Godoy GJ,Olivera C,Paira DA,Rivero VE

    更新日期:2018-12-01 00:00:00

  • Evaluation of effectiveness of antiandrogen treatments on cavernosal tissues in rats.

    abstract::In this study, we aimed to compare changes in cavernosal tissues in rats with antiandrogen treatment and orchiectomy. A total of 42 Wistar albino rats were divided into four groups. Group I, control group, Group II, LH-RH was given for 1 month, Group III-LH-RH + Bicalutamide was given for 1 month, and Group IV was def...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13567

    authors: Firat F,Erdemir F,Günaydın B,Parlaktas BS,Markoç F,Yaşar A

    更新日期:2020-06-01 00:00:00

  • Protective influence of rosiglitazone against testicular ischaemia-reperfusion injury in rats.

    abstract::Testicular torsion is a urology urgent disease which causes testicular injury and potential sterility. In this study, we explored the protective influence of rosiglitazone on testicular ischaemia-reperfusion damage. There were 28 male Sprague Dawley rats in total, which were assigned randomly to four groups. Group A w...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12947

    authors: Zheng N,Shao H,Wu D,Shen D,Lin X

    更新日期:2018-01-09 00:00:00

  • Sperm selection strategies and their impact on assisted reproductive technology outcomes.

    abstract::The application of assisted reproductive technologies (ART) has revolutionised the treatment of human infertility, giving hope to the patients previously considered incapable of establishing pregnancy. While semen analysis is performed to access whether a sample has an adequate number of viable, motile and morphologic...

    journal_title:Andrologia

    pub_type: 杂志文章,评审

    doi:10.1111/and.13725

    authors: Pinto S,Carrageta DF,Alves MG,Rocha A,Agarwal A,Barros A,Oliveira PF

    更新日期:2020-06-28 00:00:00

  • Genetic studies in varicocele infertility. II: Dermatoglyphic pattern.

    abstract::The prime concern of the present work was the analysis of dermatoglyphic patterns in infertile patients presenting with clinically detectable varicocele. In a controlled study conducted on 30 patients and utilizing a slight modification of the original ink method of Cummins and Midlo, the dermatoglyphics on terminal p...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1984.tb00244.x

    authors: Salam EA,Hafiez AR,El Kerdasi Z,Aiad F,Mahmoud KZ

    更新日期:1984-03-01 00:00:00

  • Variations in elemental distribution in human spermatozoa.

    abstract::Morphologically normal spermatozoa from groups of men attending the infertility clinic with normal density and motility had subcellular elemental composition measurements from various parts of the spermatozoa compared with anatomically similar spermatozoa from semen with marked oligo- or asthenozoospermia. In the two ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1988.tb01060.x

    authors: Sheppard BL,Harrison RF,Sheppard U,Jordan M,Hannon K

    更新日期:1988-05-01 00:00:00

  • Nonarteritic ischaemic optic neuropathy (NAION) after 36 h of intake of sildenafil citrate: first Egyptian case.

    abstract::Sildenafil citrate is a selective phosphodiesterase 5 (PDE-5) inhibitor and partial phosphodiesterase 6 inhibitor prescribed for erectile dysfunction. Post-marketing case reports of nonarteritic anterior ischaemic optic neuropathy (NAION) over the past few years suggest a potential link with PDE-5 inhibitors. We repor...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.2009.00933.x

    authors: El-Domyati MM,El-Fakahany HM,Morad KE

    更新日期:2009-10-01 00:00:00

  • Evaluation of human sperm membrane integrity using the water test and the hypoosmotic test.

    abstract::The objective of the study was to compare the water test and the hypoosmotic test (HOS) in the assessment of the human sperm membrane. A total of 686 semen samples from human male donors were subjected to water and HOS tests after routine semen evaluation. The mean percentage of swollen spermatozoa was 71.8 +/- 9.6% i...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1046/j.1439-0272.2001.00374.x

    authors: Bahamondes L,Fazano F,De Lucio MA,Neves PA,Bottcher Luiz F,Lorenzetti GB

    更新日期:2001-03-01 00:00:00

  • Thyroid response to dexamethasone: a study on normal controls and patients with psychogenic sexual dysfunction.

    abstract::Pre- and postdexamethasone triiodothyronine (T3), thyroxine (T4), and TSH levels of thirteen patients with psychogenic sexual dysfunction and thirteen controls were studied. Patients showed lowered T4 levels in comparison with the control group whereas T3 and TSH levels did not differ significantly. Dexamethasone had ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:

    authors: Noder M,Rupprecht R,Rupprecht M,Rupprecht C,Hornstein OP

    更新日期:1990-01-01 00:00:00

  • Protective effect of rutin on mercuric chloride-induced reproductive damage in male rats.

    abstract::This study investigated the effects of rutin against reproductive damage caused by toxic mercury in male rats. Thirty-five Sprague Dawley rats were used. Control group was injected with saline for 7 days. The rutin-100 group received 100 mg/kg/b.w. rutin for 7 days. Mercuric chloride (HgCl2 ) group received 1.23 mg/kg...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13524

    authors: Kandemir FM,Caglayan C,Aksu EH,Yildirim S,Kucukler S,Gur C,Eser G

    更新日期:2020-04-01 00:00:00

  • Separation of sub-populations of sperm with higher fertility potential from normal and pathological semen by peanut agglutinin.

    abstract::Incubation of human sperm from semen with counts below 20 x 10(6)/ml with peanut agglutinin (PNA) resulted in agglutination of about 70% of sperm. An inverse correlation was found between non-agglutinating (PNA) sperm and sperm density (r = 0.48, p less than 0.01) and a direct correlation with acrosome-damaged sperm (...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1990.tb01970.x

    authors: Ravid A,Sagiv M,Bartoov B,Eltes F,Novogrodsky A,Allalouf D,Levinsky H,Singer R

    更新日期:1990-05-01 00:00:00

  • Spermagglutinating antibodies: a comparison of three different techniques.

    abstract::In 136 patients tests were performed to demonstrate circulating spermagglutinating antibodies. In patients with "unexplained" infertility (15 cases) antibodies were demonstrated in six (40%) whereas in patients where another cause for infertility was present (101 cases) additional positive spermagglutinating antibodie...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1980.tb00570.x

    authors: Franken DR,Slabber CF

    更新日期:1980-01-01 00:00:00

  • Protective effect of thymoquinone against testicular torsion induced oxidative injury.

    abstract::We aimed to determine the protective effects of thymoquinone (TQ), against ischaemia-reperfusion (I/R) injury in the testis tissue of rats. Twenty-seven male Wistar albino rats were randomly divided into three equal groups as follows: Group I, sham group; Group II, torsion group; and Group III, torsion + thymoquinone ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12424

    authors: Ayan M,Tas U,Sogut E,Caylı S,Kaya H,Esen M,Erdemir F,Uysal M

    更新日期:2016-03-01 00:00:00

  • Effect of lycopene on testicular androgenic and anti-oxidative enzymes in cyproterone acetate-induced male infertile Wistar strain albino rats: An in vitro study.

    abstract::Incidents of male infertility are mushrooming worldwide. Oxidative stress plays a prime role for its onset. Considering this background, the study was designed to focus the direct role of lycopene on cyproterone acetate (CPA) induced testicular hypofunction in rat. Four groups have been considered including the vehicl...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13494

    authors: Tripathy A,Ara F,Ghosh P,Ghosh D

    更新日期:2020-04-01 00:00:00

  • Altered gene expression profiles of testicular tissues from azoospermic patients with maturation arrest.

    abstract::Maturation arrest is a common cause of male infertility which has caused worldwide concern, and its pathophysiological process remains further elucidation. Our study aimed to identify genetic characteristics of maturation arrest by comparing gene expression between maturation arrest and normal samples using microarray...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13812

    authors: Fang Y,Liu D,Yang Y,Zhang H,Wu H,Jiang H,Zhao L,Zhang Z

    更新日期:2020-12-01 00:00:00

  • The diagnostic and prognostic significance of the testicular biopsy.

    abstract::The authors present the histological features of the testes in 1,609 cases of male sterility. In 485 cases (30.1%), histological changes were found, which did not warrant treatment. The histologic pattern of the testes was normal in only 39% of the cases of azoospermia; and only these patients were qualified for surge...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1978.tb03057.x

    authors: Janczewski Z,Bablok L

    更新日期:1978-09-01 00:00:00

  • Active immunization with relaxin does not influence objectively determined sperm motility characteristics in rabbits.

    abstract::Two groups of 5 rabbits were actively immunized with porcine relaxin or sham immunized. Serial analysis of sperm motion characteristics using the computer assisted Hamilton-Thorn Motility Analyzer over a period of 22 weeks did not reveal any significant antibody titers in serum and seminal plasma. In consideration of ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1990.tb01961.x

    authors: Jockenhövel F,Altensell A,Nieschlag E

    更新日期:1990-03-01 00:00:00

  • Leydig cell function and morphology in the rat testis after exposure to heat.

    abstract::Leydig cell function, as judged from testosterone concentrations in plasma and in testicular tissue after LH stimulation, was tested in adult rat testes 4 days after brief exposure of the scrotum to 33 degrees and 43 degrees C, respectively. There was no significant difference in basal plasma testosterone concentratio...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1980.tb00568.x

    authors: Damber JE,Bergh A,Janson PO

    更新日期:1980-01-01 00:00:00

  • Molecular characterisation of a case of dicentric Y presented as nonobstructive azoospermia with testicular early maturation arrest.

    abstract::The dicentric Y chromosome is the most common cytogenetically visible structural abnormality of Y chromosome. The sites of break and fusion of dicentric Y are variable, but break and fusion at Yq12 (proximal to the pseudoautosomal region 2/PAR 2) is very rare. Dicentric Y chromosome is unstable during cell division an...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.12886

    authors: Kumar P,Jain M,Kalsi AK,Halder A

    更新日期:2018-03-01 00:00:00

  • The presence of progressive motility sustaining factor (PMSF) in human epididymis.

    abstract::Progressive Motility Sustaining Factor (PMSF) was isolated from human epididymides. PMSF could significantly improve progressive motility of oligozoospermic as well as asthenozoospermic semen. PMSF was found to increase cyclic AMP accumulation by the human spermatozoa indicating its possible mode of action. ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1981.tb00021.x

    authors: Sheth AR,Gunjikar AN,Shah GV

    更新日期:1981-03-01 00:00:00

  • Vimentin expression in spermatogenic and Sertoli cells is stage-related in rat seminiferous epithelium.

    abstract::Monoclonal and polyclonal antibodies were used in indirect immunofluorescence microscopy to localize vimentin intermediate filaments in the rat seminiferous epithelium. During stages XII-V of the epithelial cycle, the Sertoli cells showed a reaction in the perinuclear area and vimentin-positive extensions, projecting ...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/j.1439-0272.1987.tb01920.x

    authors: Mali P,Virtanen I,Parvinen M

    更新日期:1987-11-01 00:00:00

  • Effect of recombinant β-defensin 1 protein on human sperm motility and viability.

    abstract::The reduction of sperm motility and subsequently reduced ability to undergo capacitation and acrosome reaction are considered as common causes of male infertility. The β-defensin family is a group of well-known secretory proteins with antimicrobial activity that contribute to the process of "sperm maturation" during t...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1111/and.13455

    authors: Khayamabed R,Tavalaee M,Taherian SS,Nasr-Esfahani MH

    更新日期:2020-02-01 00:00:00

  • Chlamydia trachomatis infection in male partners of infertile couples: incidence and sperm function.

    abstract::Chlamydia trachomatis infection is one of the most common sexually transmitted diseases. Its effect on male fertility, however, is still controversial. In this study, 284 male partners of infertile couples consulting the Center of Studies in Reproductive Biology (CEBRE) were analyzed. The incidence of C. trachomatis i...

    journal_title:Andrologia

    pub_type: 杂志文章

    doi:10.1046/j.1439-0272.2002.00472.x

    authors: Vigil P,Morales P,Tapia A,Riquelme R,Salgado AM

    更新日期:2002-06-01 00:00:00