Kinetic parameters of platelet aggregation as an expression of platelet responsiveness.

abstract：:We have recently demonstrated that the proinflammatory cytokine, interleukin-6 (IL-6), could upregulate the production of protein S in the human hepatoma cell line, HepG-2, but not in endothelial cells. In this study, we have demonstrated that the combination of exogenous IL-6 and soluble IL-6 receptor (sIL-6R) could ...

journal_title：Thrombosis and haemostasis

authors： Hooper WC,Phillips DJ,Evatt BL

更新日期：1997-05-01 00:00:00

abstract：:Magnesium deficiency is associated with a high frequency of cardiac arrhythmia, hypertension and sudden ischemic death. We investigated the if vivo effects of intravenous magnesium administration in a rat model of chemically induced (FeCl3) carotid thrombosis. The infusion of magnesium sulfate (MgSO4) before the topic...

journal_title：Thrombosis and haemostasis

authors： Mussoni L,Sironi L,Tedeschi L,Calvio AM,Colli S,Tremoli E

更新日期：2001-11-01 00:00:00

abstract：:Platelet activation plays a pivotal role in physiological hemostasis and pathological thrombosis causing heart attack and stroke. Previous studies conclude that simultaneous activation of Gi and G12/13 signaling pathways is sufficient to cause platelet aggregation. However, using Gq knockout mice and Gq-specific inhib...

journal_title：Thrombosis and haemostasis

authors： Zhang J,Zhang Y,Zheng S,Liu Y,Chang L,Pan G,Hu L,Zhang S,Liu J,Kim S,Dong J,Ding Z

更新日期：2020-11-01 00:00:00

abstract：:The biologically active components from Viperidae venoms specifically affect cell-matrix interactions, and have been utilized for developing anti-adhesive therapy as anti-thrombotic and anti-angiogenic agents. Utilizing platelet aggregometry coupled with flow cytometry, we found that a metalloproteinase isolated from ...

journal_title：Thrombosis and haemostasis

authors： Tseng YL,Lee CJ,Huang TF

更新日期：2004-02-01 00:00:00

abstract：:LMWH preparations have been proven to be safe and effective in the out-patient management of acute DVT. Although LMWHs are more expensive than unfractionated heparin, the lack of need for laboratory monitoring of LMWHs and their potential for out-patient treatment more than offsets the drug related cost difference and...

journal_title：Thrombosis and haemostasis

authors： Hirsh J,Crowther M

更新日期：1997-07-01 00:00:00

abstract：:A model has been developed to study the transport of fluid and macromolecules through human arterial umbilical cord endothelial cell monolayers in vitro. Cells were cultured on fibronectin-coated polycarbonate filters and formed within a few days a tight monolayer, with an electrical resistance of 17 +/- 4 Ohm.cm2. Th...

journal_title：Thrombosis and haemostasis

authors： Langeler EG,van Hinsbergh VW

更新日期：1988-10-31 00:00:00

abstract：BACKGROUND:Patients undergoing surgery for cancer are at high risk for venous thromboembolism (VTE). Agents that selectively inhibit thrombin, such as dermatan sulphate, have potential for a favourable benefit-risk ratio in the prevention of this complication. METHODS:Patients scheduled for elective abdominal, thoraci...

journal_title：Thrombosis and haemostasis

authors： Di Carlo V,Agnelli G,Prandoni P,Coccheri S,Gensini GF,Gianese F,Mannucci PM

更新日期：1999-07-01 00:00:00

abstract：:This study was performed to assess the prevalence of deep vein thrombosis (DVT) in consecutive obstetric patients with clinical symptoms of DVT, using impedance plethysmography (IPG) as the diagnostic method and to establish the safety of withholding anticoagulant therapy in patients with a repeatedly normal IPG. In a...

journal_title：Thrombosis and haemostasis

authors： de Boer K,Büller HR,ten Cate JW,Levi M

更新日期：1992-01-23 00:00:00

abstract：:Von Willebrand disease (VWD) is the most common inherited bleeding disorder and is mainly caused by dominant-negative mutations in the multimeric protein von Willebrand factor (VWF). These mutations may either result in quantitative or qualitative defects in VWF. VWF is an endothelial protein that is secreted to the c...

journal_title：Thrombosis and haemostasis

authors： de Jong A,Dirven RJ,Boender J,Atiq F,Anvar SY,Leebeek FWG,van Vlijmen BJM,Eikenboom J

更新日期：2020-11-01 00:00:00

abstract：:Hyperglycemia-induced mitochondrial overproduction of reactive oxygen species leads to the activation of different biochemical pathways involved in endothelial damage of the diabetic retina. Tenilsetam [(+/-)-3-(2-thienyl)-2-piperazinone] is a dicarbonyl scavenger in the millimolar range and a transition metal ion che...

journal_title：Thrombosis and haemostasis

authors： Hoffmann J,Alt A,Lin J,Lochnit G,Schubert U,Schleicher E,Chavakis T,Brownlee M,Van der Woude FJ,Preissner KT,Hammes HP

更新日期：2006-04-01 00:00:00

abstract：:Pannexin1 (Panx1) forms ATP channels that play a critical role in the immune response by reinforcing purinergic signal amplification in the immune synapse. Platelets express Panx1 and given the importance of ATP release in platelets, we investigated Panx1 function in platelet aggregation and the potential impact of ge...

journal_title：Thrombosis and haemostasis

authors： Molica F,Morel S,Meens MJ,Denis JF,Bradfield PF,Penuela S,Zufferey A,Monyer H,Imhof BA,Chanson M,Laird DW,Fontana P,Kwak BR

更新日期：2015-08-01 00:00:00

abstract：:Components of the adaptive immune system, in particular lymphocytes and immunoglobulin, play a major role in advanced atherosclerotic lesions. We sought to determine whether routine, measurements of the relative number of circulating lymphocytes (%L) and gamma-globulin (%G) reflecting immunoglobulin are related to eve...

journal_title：Thrombosis and haemostasis

authors： Niessner A,Graf S,Nikfardjam M,Lehr S,Maurer G,Wojta J,Huber K

更新日期：2005-02-01 00:00:00

abstract：:Excessive leukocyte infiltration causes severe tissue damage in a variety of inflammatory diseases. The initial step in leukocyte extravasation is mediated by selectins and oligosaccharides on their glycoconjugate ligands. Human milk is a rich source of lactose-derived oligosaccharides that are partly absorbed in the ...

journal_title：Thrombosis and haemostasis

authors： Bode L,Kunz C,Muhly-Reinholz M,Mayer K,Seeger W,Rudloff S

更新日期：2004-12-01 00:00:00

abstract：:Thrombin activatable fibrinolysis inhibitor (TAFI) attenuates fibrinolysis and is considered as an attractive drug target. We generated two different antibody fragments, an antigen-binding fragment (Fab) and a single-chain variable fragment (scFv), derived from three distinct monoclonal antibodies (MAs) that inhibit t...

journal_title：Thrombosis and haemostasis

authors： Develter J,Dewilde M,Gils A,Declerck PJ

更新日期：2009-07-01 00:00:00

abstract：:Heparanase is implicated in angiogenesis and tumour progression. We previously demonstrated that heparanase might also affect the haemostatic system in a non-enzymatic manner. It forms a complex and enhances the activity of the blood coagulation initiator tissue factor (TF). Peptides that we generated from TF pathway ...

journal_title：Thrombosis and haemostasis

authors： Crispel Y,Axelman E,Tatour M,Kogan I,Nevo N,Brenner B,Nadir Y

更新日期：2016-09-27 00:00:00

abstract：:Wide variations in procoagulant properties, lipid composition and ultrastructure of five commonly used APTT methods have been demonstrated. Performance of the methods with a range of coagulation abnormalities has been ranked. Most of the reagents obtained a high score with one or more defects, but a low score with oth...

journal_title：Thrombosis and haemostasis

authors： Stevenson KJ,Easton AC,Curry A,Thomson JM,Poller L

更新日期：1986-04-30 00:00:00

abstract：:Malondialdehyde (MDA) is a stable produce of arachidonic acid metabolism, catalyzed by the enzyme cyclo-oxygenase. The experimental conditions for measuring the kinetics of MDA formation in rat citrated platelet-rich plasma were defined. Platelets were stimulated with either arachidonic acid, the substrate of MDA, or ...

journal_title：Thrombosis and haemostasis

authors： Rajtar G,Livio M,Merino J,de Gaetano G

更新日期：1980-10-31 00:00:00

abstract：:Circulating endotoxin is elevated in sepsis and plays a role in endothelial dysfunction whereas antithrombin is decreased by virtue of its consumption during complex formation with clotting factors and by proteolytic degradation by granulocyte elastase. Dysfunction of endothelium results in enhanced leukocyte rolling ...

journal_title：Thrombosis and haemostasis

authors： Kaneider NC,Förster E,Mosheimer B,Sturn DH,Wiedermann CJ

更新日期：2003-12-01 00:00:00

abstract：:Local ISI calibration has been proposed to improve INR accuracy and inter-laboratory precision. We evaluated the affect of local PT calibration on INR precision and accuracy using six levels of frozen plasma calibrants prepared and pooled from normal donors and patients stabilized on sodium warfarin (coumarin) based o...

journal_title：Thrombosis and haemostasis

authors： Adcock DM,Johnston M

更新日期：2002-01-01 00:00:00

abstract：:The interaction of beta 2-glycoprotein-I (beta 2-G-I), a plasma constituent of unknown function, with blood platelets was studied. The following results were obtained: 1) beta 2-G-I binds to washed human platelets isolated by centrifugation (WP) at one kind of specific, saturable binding sites. The dissociation consta...

journal_title：Thrombosis and haemostasis

authors： Nimpf J,Wurm H,Kostner GM

更新日期：1985-08-30 00:00:00

abstract：:Recombinant factor VIIa (rVIIa) has been reported to be clinically effective and safe in haemophilic patients with inhibitor antibodies. Compared to activated prothrombin complex concentrates the risk of thrombotic complications seems to be very low after rVIIa administration. Determination of free thrombin generation...

journal_title：Thrombosis and haemostasis

authors： Gallistl S,Cvirn G,Muntean W

更新日期：1999-02-01 00:00:00

abstract：:Although sepsis-induced release of nitric oxide (NO) is known to have an antithrombotic effect, it is unknown if NO exerts this same effect under physiological conditions. We have there-fore attempted to determine whether or not NO protects against thrombus formation in normal Wistar rats injected with various amounts...

journal_title：Thrombosis and haemostasis

authors： Asakura H,Okudaira M,Ontachi Y,Mizutani T,Omote M,Yoshida T,Kaneda M,Yamazaki M,Morishita E,Takami A,Miyamoto K,Nakao S

更新日期：2004-01-01 00:00:00

abstract：:The fibrinolytic capacity of 121 patients with a history of venous thrombosis and/or pulmonary embolism was studied by venous occlusion technique, at earliest 3 months after the last thromboembolic episode. After discontinuation of oral anticoagulation treatment the clinical course of the patients was followed and new...

journal_title：Thrombosis and haemostasis

authors： Korninger C,Lechner K,Niessner H,Gössinger H,Kundi M

更新日期：1984-10-31 00:00:00

abstract：:Patients with both chronic kidney disease (CKD) and diabetes mellitus (DM) are at increased risk for thrombotic events compared to those with one abnormality alone. Whether this can be attributed to changes in platelet reactivity among those with both CKD and DM is unknown. We prospectively studied 438 clopidogrel-naï...

journal_title：Thrombosis and haemostasis

authors： Baber U,Bander J,Karajgikar R,Yadav K,Hadi A,Theodoropolous K,Gukathasan N,Roy S,Sayeneni S,Scott SA,Kovacic JC,Yu J,Sartori S,Mehran R,Uribarri J,Badimon JJ,Muntner P,Moreno P,Kini AS,Sharma SK

更新日期：2013-07-01 00:00:00

abstract：:There is no patient-reported medication adherence measure that has been validated in Singapore. This study aimed to validate the 8-item Morisky Medication Adherence Scale (MMAS) in patients taking warfarin in Singapore. A cross-sectional survey was conducted in a convenience sample of 151 patients taking warfarin at a...

journal_title：Thrombosis and haemostasis

authors： Wang Y,Kong MC,Ko Y

更新日期：2012-10-01 00:00:00

abstract：:Patients with atrial fibrillation at moderate to high risk of stroke are not always anticoagulated despite a lack of contraindications to vitamin K antagonists (VKAs) like warfarin. These patients are treated with aspirin, aspirin-clopidogrel combination therapy or even receive no thromboprophylaxis. The oral direct t...

journal_title：Thrombosis and haemostasis

authors： Roskell NS,Lip GY,Noack H,Clemens A,Plumb JM

更新日期：2010-12-01 00:00:00

abstract：:Light to moderate drinking is associated with lower risk of coronary heart (CHD) than non-drinkers. We have examined the relationships between total alcohol intake and type of alcoholic beverage and several potential biological mechanisms. We carried out the study in 3158 men aged 60-79 years drawn from general practi...

journal_title：Thrombosis and haemostasis

authors： Wannamethee SG,Lowe GD,Shaper G,Whincup PH,Rumley A,Walker M,Lennon L

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND: Anticoagulant therapy has seldom been achieved in randomized trials targeting nonspecific overall sepsis patients. Although the key components to identify the appropriate target in sepsis may be disseminated intravascular coagulation (DIC) and high disease severity, the interaction and relation of these two...

journal_title：Thrombosis and haemostasis

authors： Yamakawa K,Gando S,Ogura H,Umemura Y,Kabata D,Shintani A,Shiraishi A,Saitoh D,Fujishima S,Mayumi T,Kushimoto S,Abe T,Shiino Y,Nakada TA,Tarui T,Hifumi T,Otomo Y,Okamoto K,Kotani J,Sakamoto Y,Sasaki J,Shiraishi S

更新日期：2019-11-01 00:00:00

abstract：:Tissue factor (thromboplastin or Factor III), a glycoprotein cofactor, is required for Factor VII to express its catalytic activity, thereby initiating the extrinsic as well as intrinsic pathway of blood coagulation. Human brain tissue factor was purified 2,500-fold to 98% homogeneity from 2% Triton X-100 extraction o...

journal_title：Thrombosis and haemostasis

authors： Kang S,Niemetz J

更新日期：1988-06-16 00:00:00

abstract：:Inherited thrombophilic states are associated with an increased risk for deep vein thrombosis (DVT), but whether they are also risk factors for superficial vein thrombosis (SVT) is uncertain. We assessed the risk conferred by inherited thrombophilic states in patients with a first episode of SVT in whom the coexistenc...

journal_title：Thrombosis and haemostasis

authors： Martinelli I,Cattaneo M,Taioli E,De Stefano V,Chiusolo P,Mannucci PM

更新日期：1999-10-01 00:00:00