Genetic evidence for the action of oxathiin and thiazole derivatives on the succinic dehydrogenase system of Ustilago maydis mitochondria.

Abstract:

:The inhibitory effect of fungitoxic derivatives of 1,4-oxathiin on substrate oxidation by the basidiomycete Ustilago maydis is diminished by a single-gene mutation (oxr). The difference between mutant and wild type is approximately the same on the basis of inhibition of either growth and operation of the tricarboxylic acid cycle in intact cells or succinate-driven reduction of ferricyanide by mitochondrial preparations. The mutation affects the behavior of the succinic dehydrogenase system of mitochondria not only in the presence but also in the absence of the toxicant, from which it is concluded that some component of the system itself has been modified. The malonate and the antimycin A sensitivity of the oxr mutant is similar to that of the wild type but cross-resistance to thiazole derivatives is easily demonstrated.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Georgopoulos SG,Alexandri E,Chrysayi M

doi

10.1128/JB.110.3.809-817.1972

subject

Has Abstract

pub_date

1972-06-01 00:00:00

pages

809-17

issue

3

eissn

0021-9193

issn

1098-5530

journal_volume

110

pub_type

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