Antibacterial nitroacridine, Nitroakridin 3582: binding to nucleic acids in vitro and effects on selected cell-free model systems of macromolecular biosynthesis.

abstract：:Polynucleotide phosphorylase (PNP) plays a central role in RNA degradation, generating a pool of ribonucleoside diphosphates (rNDPs) that can be converted to deoxyribonucleoside diphosphates (dNDPs) by ribonucleotide reductase. We report here that spontaneous mutations resulting from replication errors, which are norm...

journal_title：Journal of bacteriology

authors： Becket E,Tse L,Yung M,Cosico A,Miller JH

更新日期：2012-10-01 00:00:00

abstract：:Induction of colicin la at a high temperature (42 C) was demonstrated in a wild strain of Shigella sonnei. After transfer of the Col factor, a similar effect was observed in those recipient cells acquiring colicinogeny. The induction is suggested to be due to the presence of a thermosensitive colicin repressor. The wi...

journal_title：Journal of bacteriology

authors： Gromkova RH

更新日期：1971-06-01 00:00:00

abstract：:The products of the bvgAS locus coordinately regulate expression of the Bordetella pertussis virulence regulon in response to environmental signals. Transcription of bvgAS-activated genes is nearly eliminated by several modulating conditions, including the presence of sulfate anion or nicotinic acid and growth at low ...

journal_title：Journal of bacteriology

authors： Miller JF,Johnson SA,Black WJ,Beattie DT,Mekalanos JJ,Falkow S

更新日期：1992-02-01 00:00:00

abstract：:Energy-coupling factor (ECF) transporters form a large group of vitamin uptake systems in prokaryotes. They are composed of highly diverse, substrate-specific, transmembrane proteins (S units), a ubiquitous transmembrane protein (T unit), and homo- or hetero-oligomeric ABC ATPases. Biotin transporters represent a spec...

journal_title：Journal of bacteriology

authors： Finkenwirth F,Kirsch F,Eitinger T

更新日期：2013-09-01 00:00:00

abstract：:More than 98% of reported human listeriosis cases are caused by Listeria monocytogenes serotypes within lineages I and II. Serotypes within lineage III (4a and 4c) are commonly isolated from environmental and food specimens. We report the first complete genome sequence of a lineage III isolate, HCC23, which will be us...

journal_title：Journal of bacteriology

authors： Steele CL,Donaldson JR,Paul D,Banes MM,Arick T,Bridges SM,Lawrence ML

更新日期：2011-07-01 00:00:00

abstract：:MotA contains a conserved C-terminal cluster of negatively charged residues, and MotB contains a conserved N-terminal cluster of positively charged residues. Charge-altering mutations affecting these residues impair motility but do not diminish Mot protein levels. The motility defects are reversed by second-site mutat...

journal_title：Journal of bacteriology

authors： Hosking ER,Manson MD

更新日期：2008-08-01 00:00:00

abstract：:The rates of synthesis of Aerobacter aerogenes nucleic acids were estimated during incubation of the bacteria in a Mg(++)-free medium. Deoxyribonucleic acid (DNA) synthesized during Mg(++) starvation, or in the preceding exponential growth, remained acid-precipitable for 2.5 hr before breaking down to acid-soluble pro...

journal_title：Journal of bacteriology

authors： Kennell D,Kotoulas A

更新日期：1967-01-01 00:00:00

abstract：:Rhythmically advancing waves of cells, called ripples, arise spontaneously during the aggregation of Myxococcus xanthus into fruiting bodies. Extracts prepared by washing rippling cells contain a substance that will induce quiescent cells to ripple. Three lines of evidence indicate that murein (peptidoglycan) is the r...

journal_title：Journal of bacteriology

authors： Shimkets LJ,Kaiser D

更新日期：1982-10-01 00:00:00

abstract：:Globomycin is an antibiotic which inhibits the processing of the prolipoprotein. Eighty globomycin-resistant mutants were independently isolated from Escherichia coli K-12 which had a deletion mutation in chromosomal lipoprotein gene (lpp), but contained a plasmid carrying the wild-type lpp gene. Twenty-six of the mut...

journal_title：Journal of bacteriology

authors： Zwiebel LJ,Inukai M,Nakamura K,Inouye M

更新日期：1981-01-01 00:00:00

abstract：:Holins are a diverse group of small integral membrane proteins elaborated by bacteriophages to lyse bacterial hosts and effect release of progeny phages in a precisely timed manner. Recently, the holin S gene of phage lambda was overexpressed and the holin protein was purified to homogeneity by means of an oligohistid...

journal_title：Journal of bacteriology

authors： Smith DL,Young R

更新日期：1998-08-01 00:00:00

abstract：:Escherichia coli possesses a soluble flavohemoglobin, with an unknown function, encoded by the hmp gene. A monolysogen containing an hmp-lacZ operon fusion was constructed to determine how the hmp promoter is regulated in response to heme ligands (O2, NO) or the presence of anaerobically utilized electron acceptors (n...

journal_title：Journal of bacteriology

authors： Poole RK,Anjum MF,Membrillo-Hernández J,Kim SO,Hughes MN,Stewart V

更新日期：1996-09-01 00:00:00

abstract：:The penultimate step in the biosynthesis of riboflavin (vitamin B2) involves the condensation of 3,4-dihydroxy-2-butanone 4-phosphate with 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione, which is catalyzed by 6,7-dimethyl-8-ribityllumazine synthase (lumazine synthase). Pathogenic Brucella species adapted to an intr...

journal_title：Journal of bacteriology

authors： Zylberman V,Klinke S,Haase I,Bacher A,Fischer M,Goldbaum FA

更新日期：2006-09-01 00:00:00

abstract：:Lipopolysaccharide (LPS) was isolated from the unicellular blue-green bacterium Agmenellum quadruplicatum using the procedure of Westphal and Jann (1965). It was composed of a lipid A and polysaccharide region suggesting a similarity to other gram-negative LPSs. Chemical analyses demonstrated the presence of glucose, ...

journal_title：Journal of bacteriology

authors： Buttke TM,Ingram LO

更新日期：1975-12-01 00:00:00

abstract：:The major acid-soluble spore proteins (ASSPs) of Bacillus subtilis were detected by immunoprecipitation of radioactively labeled in vitro- and in vivo-synthesized proteins. ASSP synthesis in vivo began 2 h after the initiation of sporulation (t2) and reached its maximum rate at t7. This corresponded to the time of syn...

journal_title：Journal of bacteriology

authors： Leventhal JM,Chambliss GH

更新日期：1982-12-01 00:00:00

abstract：:The Escherichia coli strain cs2-68 is a cold-sensitive (c) mutant that forms a long filamentous cell at 20 degrees C with a large nucleoid mass in its central region. We have recently shown that the pcsA68 mutation causing the cs phenotype is a single-base substitution within the dinD gene, a DNA damage-inducible gene...

journal_title：Journal of bacteriology

authors： Yasuda T,Nagata T,Ohmori H

更新日期：1996-07-01 00:00:00

abstract：:Open reading frame orf192, which is located immediately upstream of the aerobic repressor gene crtJ, was genetically and biochemically demonstrated to code for a second aerobic repressor (AerR) of photosynthesis gene expression in Rhodobacter capsulatus. Promoter-mapping studies indicate that crtJ has its own promoter...

journal_title：Journal of bacteriology

authors： Dong C,Elsen S,Swem LR,Bauer CE

更新日期：2002-05-01 00:00:00

abstract：:The gene encoding the outer membrane phosphate-selective porin protein P from Pseudomonas aeruginosa was cloned into Escherichia coli. The protein product was expressed and transported to the outer membrane of an E. coli phoE mutant and assembled into functional trimers. Expression of a product of the correct molecula...

journal_title：Journal of bacteriology

authors： Siehnel RJ,Worobec EA,Hancock RE

更新日期：1988-05-01 00:00:00

abstract：:The Bacillus anthracis endospore loses resistance properties during germination when its cortex peptidoglycan is degraded by germination-specific lytic enzymes (GSLEs). Although this event normally employs several GSLEs for complete cortex removal, the SleB protein alone can facilitate enough cortex hydrolysis to prod...

journal_title：Journal of bacteriology

authors： Heffron JD,Sherry N,Popham DL

更新日期：2011-01-01 00:00:00

abstract：:By using a method that labels sulfhydryl-containing proteins in situ, we have detected a major outer membrane protein of Neisseria gonorrhoeae at 41 kDa. A protein of this molecular mass has not previously been shown to be a major outer membrane protein in gonococci. In addition, a minor protein rich in cysteinyl resi...

journal_title：Journal of bacteriology

authors： Norrod EP,Browne SL,Feldweg A,Leonard J

更新日期：1993-02-01 00:00:00

abstract：:Wiebers, Joyce L. (Purdue University, West Lafayette, Ind.), and Harold R. Garner. Use of S-methylcysteine and cystathionine by methionineless Neurospora mutants. J. Bacteriol. 88:1798-1804. 1964.-Radioactive methionine was found in hydrolysates of various strains of Neurospora crassa when either S-methylcysteine (SMC...

journal_title：Journal of bacteriology

authors： WIEBERS JL,GARNER HR

更新日期：1964-12-01 00:00:00

abstract：:The ability of Clostridium perfringens type A to produce an enterotoxin active in human food poisoning has been shown to be directly related to the ability of the organism to sporulate. Enterotoxin was produced only in a sporulation medium and not in a growth medium in which sporulation was repressed. Mutants with an ...

journal_title：Journal of bacteriology

authors： Duncan CL,Strong DH,Sebald M

更新日期：1972-04-01 00:00:00

abstract：:Despite the fact that phosphoenolpyruvate carboxylase (PEPC) activity has been measured and in some cases even purified from some Archaea, the gene responsible for this activity has not been elucidated. Using sensitive sequence comparison methods, we detected a highly conserved, uncharacterized archaeal gene family th...

journal_title：Journal of bacteriology

authors： Ettema TJ,Makarova KS,Jellema GL,Gierman HJ,Koonin EV,Huynen MA,de Vos WM,van der Oost J

更新日期：2004-11-01 00:00:00

abstract：:Streptococcus suis serotype 2 is a highly invasive, extracellular pathogen in pigs with the capacity to cause severe infections in humans. This study was initiated by the finding that IgM degradation products are released after opsonization of S. suis. The objective of this work was to identify the bacterial factor re...

journal_title：Journal of bacteriology

authors： Seele J,Singpiel A,Spoerry C,von Pawel-Rammingen U,Valentin-Weigand P,Baums CG

更新日期：2013-03-01 00:00:00

abstract：:Aerobacter cloacae UW-C83 and Escherichia coli K-12 were grown under various anaerobic environments. Y(atp) values were calculated by determination of cell weights and analyses for fermentation products. These Y(atp) values are compared with others reported in the literature. Limitation of growth by factors other than...

journal_title：Journal of bacteriology

authors： Hernandez E,Johnson MJ

更新日期：1967-10-01 00:00:00

abstract：:The interaction of 12 phage strains with bacilli, protoplasts, and L forms of Bacillus subtilis 168 and with eight of its mutants and two of its lysogens is described qualitatively and quantitatively. After removal of the cell wall from B. subtilis 168, 11 of the 12 phage strains can still adsorb to the protoplasts, n...

journal_title：Journal of bacteriology

authors： Jacobson ED,Landman OE

更新日期：1975-10-01 00:00:00

abstract：:In many bacteria, the ferric uptake regulator (Fur) protein plays a central role in the regulation of iron uptake genes. Because iron figures prominently in the agriculturally important symbiosis between soybean and its nitrogen-fixing endosymbiont Bradyrhizobium japonicum, we wanted to assess the role of Fur in the i...

journal_title：Journal of bacteriology

authors： Benson HP,LeVier K,Guerinot ML

更新日期：2004-03-01 00:00:00

abstract：:Nosocomial infections caused by antibiotic-resistant Klebsiella pneumoniae are emerging as a major health problem worldwide, while community-acquired K. pneumoniae infections present with a range of diverse clinical pictures in different geographic areas. In particular, an invasive form of K. pneumoniae that causes li...

journal_title：Journal of bacteriology

authors： Wu KM,Li LH,Yan JJ,Tsao N,Liao TL,Tsai HC,Fung CP,Chen HJ,Liu YM,Wang JT,Fang CT,Chang SC,Shu HY,Liu TT,Chen YT,Shiau YR,Lauderdale TL,Su IJ,Kirby R,Tsai SF

更新日期：2009-07-01 00:00:00

abstract：:The salmonellae are a diverse group of bacteria within the family Enterobacteriaceae that includes two species, Salmonella enterica and Salmonella bongori. In order to characterize the phylogenetic relationships of the species and subspecies of Salmonella, we analyzed four housekeeping genes, gapA, phoP, mdh and recA,...

journal_title：Journal of bacteriology

authors： McQuiston JR,Herrera-Leon S,Wertheim BC,Doyle J,Fields PI,Tauxe RV,Logsdon JM Jr

更新日期：2008-11-01 00:00:00

abstract：:Chronic lung infections in cystic fibrosis (CF) could be treated more effectively if the effects of antimicrobials on pathogens in situ were known. Here, we compared changes in the microbial community composition and pathogen growth rates in longitudinal studies of seven pediatric CF patients undergoing intravenous an...

journal_title：Journal of bacteriology

authors： Neubauer C,Kasi AS,Grahl N,Sessions AL,Kopf SH,Kato R,Hogan DA,Newman DK

更新日期：2018-11-26 00:00:00

abstract：:Chlamydia trachomatis lacks the canonical genes required for the biosynthesis of p-aminobenzoate (pABA), a component of essential folate cofactors. Previous studies revealed a single gene from C. trachomatis, the CT610 gene, that rescues Escherichia coli ΔpabA, ΔpabB, and ΔpabC mutants, which are otherwise auxotrophic...

journal_title：Journal of bacteriology

authors： Macias-Orihuela Y,Cast T,Crawford I,Brandecker KJ,Thiaville JJ,Murzin AG,de Crécy-Lagard V,White RH,Allen KD

更新日期：2020-09-23 00:00:00