Abstract:
:A class of heterogeneous nuclear RNA (hnRNA) molecules contain an internal transcribed poly A sequence of close to 25 uninterrupted AMP residues. HnRNA molecules containing this sequence are separable from those containing the large 3' terminal poly A sequence on the basis of their differential affinity for oligo dT cellulose. The fact that the transcribed small poly A and the 3' terminal poly A are not found in the same hnRNA molecules even though both are present in similar size classes and that the small poly A is absent from cytoplasmic messenger RNA (mRNA) has led us to propose a scheme for mRNA processing in which the 3' end of the small poly A in hnRNA becomes a priming size for the post-transcriptional addiction of the large poly A.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Venkatesan S,Nakazato H,Kopp DW,Edmonds Mdoi
10.1093/nar/6.3.1097subject
Has Abstractpub_date
1979-03-01 00:00:00pages
1097-110issue
3eissn
0305-1048issn
1362-4962journal_volume
6pub_type
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