Abstract:
:A sensitive and convenient method of endopeptidase assay using as substrate globin modified with pyridoxal-5-phosphate was used for determination of acid proteinases in bovine hypothalamus separated by isoelectric focusing. The soluble protein fraction of hypothalamus upon elution from Sephadex gave five peaks of proteinase activity at pH 3.2. The properties indicate that these peaks of endopeptidase activity are isoenzyme forms of cathepsin D.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Akopyan TN,Barchudaryan NA,Karabashyan LV,Arutunyan AA,Lajtha A,Galoyan AAdoi
10.1002/jnr.490040505subject
Has Abstractpub_date
1979-01-01 00:00:00pages
365-70issue
5-6eissn
0360-4012issn
1097-4547journal_volume
4pub_type
杂志文章abstract::Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490350409
更新日期:1993-07-01 00:00:00
abstract::Astrogliosis and microglial reactions are correlated with the formation of scar tissue and synapse loss. 4-hydroxy-tempo (TEMPOL) is a reactive oxygen species scavenger with proven neuroprotective efficacy in experimental models of traumatic injury and cerebral ischemia. TEMPOL has not, however, been applied following...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24365
更新日期:2019-04-01 00:00:00
abstract::Several recently discovered lines of evidence support the involvement of myelin basic protein (BP)-specific T cells in multiple sclerosis (MS). To identify potentially relevant immunodominant T cell epitopes, human BP (Hu-BP)-reactive T cell lines were selected from MS and normal donors and tested for reactivity to cl...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490280215
更新日期:1991-02-01 00:00:00
abstract::Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490400216
更新日期:1995-02-01 00:00:00
abstract::We have shown previously that in oligodendrocytes, the transcription factor cyclic AMP response element binding protein (CREB) is maximally expressed immediately prior to the most rapid period of myelination in rat brain. We have begun to investigate the role of this protein during myelination by downregulating CREB s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19961001)46:1<98::AID-JNR1
更新日期:1996-10-01 00:00:00
abstract::To explore the feasibility of cell type-specific gene expression in oligodendrocytes as a possible therapeutic approach for demyelinating diseases, the cell specificity, tissue specificity, and duration of gene expression were investigated using recombinant adeno-associated viral vectors (rAAV) carrying a green fluore...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990215)55:4<504::AID-JNR
更新日期:1999-02-15 00:00:00
abstract::Convergent lines of evidence have recently highlighted β3-adrenoreceptors (ARs) as a potentially critical target in the regulation of nervous and behavioral functions, including memory consolidation, anxiety, and depression. Nevertheless, the role of β3-ARs in the cerebellum has been never investigated. To address thi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24712
更新日期:2020-11-01 00:00:00
abstract::Gangliosides, sialic acid-containing glycosphingolipids, are ubiquitously expressed in all eukaryotic cells and are localized primarily in the plasma membrane. For a rat pheochromocytoma cell line, PC12, which has been used frequently as a model for investigating events leading to neuronal differentiation, it is gener...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21031
更新日期:2006-11-01 00:00:00
abstract::Acoustic overstimulation causes apoptotic cell death in the cochlea. This death process is mediated, in part, by the mitochondrial signaling pathway involving Bcl-2 family proteins. Myeloid cell leukemia sequence 1 (Mcl-l) is an antiapoptotic member of the Bcl-2 family. Its involvement in noise-induced hair cell death...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22333
更新日期:2010-06-01 00:00:00
abstract::Inhibitors of differentiation (Id) play an essential role in the neurogenesis of the central nervous system. However, the expression and function of Id in the development of cochlear sensory epithelial cells have yet to be elucidated. In this study, we demonstrate the Id1 gene was expressed in the rapidly growing otoc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21133
更新日期:2007-02-15 00:00:00
abstract::The response of cells localized in the brain subventricular zone (SVZ) to growth factor stimulation has been largely described for development and adult life, whereas no information on their behavior during aging is available. To address the question of whether the cells in the SVZ of old mice respond to the intracere...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10614
更新日期:2003-06-01 00:00:00
abstract::Previously, we reported that chelation of intracellular zinc with N, N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN)-induced macromolecule synthesis-dependent apoptosis of cultured cortical neurons. According to the current theory of apoptosis, release of mitochondrial cytochrome C into the cytosol is required...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/1097-4547(20000901)61:5<508::AID-JNR5>3.0.
更新日期:2000-09-01 00:00:00
abstract::The most visible and, until very recently, the only hypothesis regarding the involvement of microglial cells in Alzheimer's disease (AD) pathogenesis is centered around the notion that activated microglia are neurotoxin-producing immune effector cells actively involved in causing the neurodegeneration that is the caus...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.20093
更新日期:2004-07-01 00:00:00
abstract::As aging population is increasing, new methodologies to apprehend and enhance the mechanisms related to optimal brain function in advancing age become urgent. This review describes how the combined use of non-invasive brain stimulation (NIBS) with functional magnetic resonance imaging (fMRI) provides novel experimenta...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24514
更新日期:2019-08-16 00:00:00
abstract::We used a modified pial vessel disruption (PVD) protocol with adult male Wistar rats to mimic small-vessel stroke in the cerebral cortex. Within 3 weeks, this lesion develops into a single lacuna-like cavity, which is fluid-filled and encapsulated by reactive astrocytes. Minocycline treatment that commences 1 hr after...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23223
更新日期:2013-07-01 00:00:00
abstract::New neurons are continuously generated throughout life in the subgranular zone in the dentate gyrus of the mammalian hippocampus and in the subventricular zone of the lateral ventricles. With the aid of new methodologies, significant progress has been made in the characterization of endogenous stem cells (ependymal ce...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23480
更新日期:2015-03-01 00:00:00
abstract::As the main input structure of the basal ganglia (BG), the striatum collects and integrates information from several brain areas and funnels them forward to other BG nuclei. The striatal projection neurons are medium-sized spiny neurons classified in two main subpopulations, based on their neurochemical characterizati...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24479
更新日期:2019-10-01 00:00:00
abstract::The present experiments tested the hypothesis that one of the critical mechanisms underlying genetically defined aggressiveness involves brain serotonin 5-HT1A receptors. 5-HT1A receptor density, the receptor mRNA expression in brain structures, and functional correlates for 5-HT1A receptors identified as 8-OH-DPAT-in...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20456
更新日期:2005-04-15 00:00:00
abstract::In this study, we examined the neuroprotective effect of standardized Bacopa monniera extract (BME: BESEB CDRI-08) against the D-galactose (D-gal)-induced brain aging in rats. Experimental groups were subjected to contextual-associative learning task. We found that the administration of BME in the D-gal-treated group ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23080
更新日期:2012-10-01 00:00:00
abstract::The ability of altered environmental conditions to modulate some properties of synaptosomes has been studied. Incubation conditions used included the presence of methyl mercury or an organochlorine insecticide: chlordecone. Other adverse chemical conditions during incubation were the absence of calcium salts from the ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250211
更新日期:1990-02-01 00:00:00
abstract::We have recently demonstrated that brain plastic events significantly modify synaptic protein synthesis measured by the incorporation of [(35)S]methionine in brain synaptosomal proteins. Notably, in rats learning a two-way active avoidance task, the local synthesis of two synaptic proteins was selectively enhanced. Be...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22037
更新日期:2009-07-01 00:00:00
abstract::Clusterin (apolipoprotein J) is a highly conserved, multifunctional, vertebrate glycoprotein. Several isoforms of clusterin have been described including the predominant secreted isoform (sCLU) and several nuclear isoforms (nCLU) associated with cell death. sCLU has been shown to bind a variety of partly unfolded, str...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20374
更新日期:2005-02-15 00:00:00
abstract::The dentate gyrus is selectively reduced in size in the insulin-like growth factor 1 (IGF1) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1084
更新日期:2001-05-15 00:00:00
abstract::The concept of the neurovascular unit emphasizes that common signals and substrates underlie the physiology and pathophysiology of neuronal and endothelial compartments in brain. Recent data suggest that activation of the integrin-associated protein CD47 promotes neuronal cell death. Is it possible that CD47 may also ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22076
更新日期:2009-08-15 00:00:00
abstract::Substance P (SP) acts as an immunoregulator by binding to specific functional cell surface receptors on a subpopulation of human T-helper lymphocytes. Receptors with similar properties have also been characterized on the human IM-9 B-lymphoblast cell line. Four distinct proteins of molecular weight (MW) 33,000, 58,000...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180127
更新日期:1987-01-01 00:00:00
abstract::Thirty-day readmission rates has been increasingly used by clinicians, hospital administrators, and policy makers as a metric for the quality of care. However, the 30-day readmission rates may be affected by other factors intrinsic to the patient and may not be a good measure of the quality of care provided by the hos...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24398
更新日期:2020-01-01 00:00:00
abstract::This Review describes the current status of poststroke epilepsy (PSE) with an emphasis on poststroke epileptogenesis modeling for testing new therapeutic agents. Stroke is a leading cause of epilepsy in an aging population. Late-onset "epileptic" seizures have been reported in up to 30% cases after stroke. Nevertheles...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23836
更新日期:2017-04-01 00:00:00
abstract::Protein kinase C (PKC) and its potential role in myelin gene expression were investigated in primary cultured rat oligodendrocytes. The major myelin genes were expressed in a developmentally coordinated manner in cultured oligodendrocytes. PKC activity in these cells was similarly regulated with differential expressio...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490340509
更新日期:1993-04-01 00:00:00
abstract::The production of collagen-degrading proteases by cultured neonatal rat microglia was examined using an immobilized fibronectin-gelatin matrix coupled to a fluorescent marker and by substrate gel analysis. When microglia were plated onto the surface of the matrix and incubated under resting (nonstimulated) conditions,...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490350309
更新日期:1993-06-15 00:00:00
abstract::Vascular smooth muscle (VSM) cells comprise one of the primary targets of the sympathetic nervous system and have been shown to secrete nerve growth factor (NGF). There is increasing evidence that changes in the levels of NGF in the adult may underlie certain pathological conditions. To investigate the potential role ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00