Abstract:
:Comparison of the nucleotide sequence of mRNAs coding for several vertebrate actins revealed a high degree of sequence homology in the 3' untranslated region (3' UTR) between those mRNAs coding for homologous (isotypic) actins in different organisms but not between mRNAs coding for very similar isoforms differing in their function or tissue specificity. A similar pattern of sequence conservation in the 3' UTR is also found in several other genes. Furthermore, while there is a great variation in the size of the 3' UTR of mRNAs coding for different proteins, mRNA coding for isotypic proteins in distantly related organisms often have 3' UTR of similar size. The data suggest that the 3' UTR may play an important role in the regulation of expression of at least some genes at the transcriptional or posttranscriptional level.
journal_name
Nucleic Acids Resjournal_title
Nucleic acids researchauthors
Yaffe D,Nudel U,Mayer Y,Neuman Sdoi
10.1093/nar/13.10.3723subject
Has Abstractpub_date
1985-05-24 00:00:00pages
3723-37issue
10eissn
0305-1048issn
1362-4962journal_volume
13pub_type
杂志文章abstract::We describe the synthesis of 2'-O-methyl, 2'-O-ethyl oligoribonucleotides and phosphorothioate oligodeoxyribonucleotides and demonstrate their utility as inhibitors of the in vitro U7 snRNP-dependent mRNA processing event. These 2'-O-modified compounds were designed to possess the binding affinity of an RNA molecule t...
journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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更新日期:2004-07-28 00:00:00
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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journal_title:Nucleic acids research
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更新日期:1996-10-15 00:00:00
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journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/gkq260
更新日期:2010-08-01 00:00:00
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journal_title:Nucleic acids research
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更新日期:1990-02-25 00:00:00
abstract::Genetic screens in Saccharomyces cerevisiae have identified the roles of ribosome components, tRNAs and translation factors in translational fidelity. These screens rely on the suppression of altered start codons, nonsense codons or frameshift mutations in genes involved in amino acid or nucleotide metabolism. Many of...
journal_title:Nucleic acids research
pub_type: 杂志文章
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更新日期:2005-08-12 00:00:00
abstract::A new method for evaluating some complex characteristics of the primary structure of E.coli promoters is proposed. The method, of nonparametric statistical significance, selects important conserved single-base positions in combination with 2-base coupling relations of identity and complementarity. The extended consens...
journal_title:Nucleic acids research
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更新日期:1989-06-26 00:00:00
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journal_title:Nucleic acids research
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更新日期:1996-05-01 00:00:00
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journal_title:Nucleic acids research
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更新日期:2008-05-01 00:00:00
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journal_title:Nucleic acids research
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更新日期:2014-04-01 00:00:00
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更新日期:1991-11-25 00:00:00
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journal_title:Nucleic acids research
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更新日期:2005-07-26 00:00:00
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journal_title:Nucleic acids research
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更新日期:1995-07-25 00:00:00
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journal_title:Nucleic acids research
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更新日期:2019-09-26 00:00:00
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journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/18.24.7235
更新日期:1990-12-25 00:00:00
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journal_title:Nucleic acids research
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更新日期:1995-03-25 00:00:00
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journal_title:Nucleic acids research
pub_type: 杂志文章
doi:10.1093/nar/gky010
更新日期:2018-02-28 00:00:00
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journal_title:Nucleic acids research
pub_type: 杂志文章
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更新日期:1998-03-15 00:00:00