Abstract:
:The purpose of this research was to study the early histologic changes occurring in the lens during the formation of selenite overdose cataract. Fourteen-day-old rat pups received a single injection of 2.25 mg Se (kg body wt)-1. Lenses at each of three stages of cataract formation were observed biomicroscopically, and then 1-2 micron sections of methacrylate-embedded lenses were evaluated with the light microscope. The first observable change was vacuolization, which started at the lens bow and later spread throughout the posterior subcapsular region (Stage 1). This was followed by an abrupt increase in basophilia at the interface between the peripheral nucleus and cortex (Stage 2). Subsequent formation of nuclear opacity was characterized by the presence of opaque particles, abnormal basophilic structures, and lens fiber damage (Stage 3). The data were consistent with the hypothesis that an early site of attack of selenite is at or near the lens bow, and this leads to biochemical changes, fiber cell damage, impaired nutrient circulation, and formation of nuclear cataract.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Shearer TR,Anderson RSdoi
10.1016/0014-4835(85)90077-6subject
Has Abstractpub_date
1985-04-01 00:00:00pages
557-65issue
4eissn
0014-4835issn
1096-0007pii
0014-4835(85)90077-6journal_volume
40pub_type
杂志文章abstract::Myo/Nog cells are essential for eye development in the chick embryo and respond to injury in adult tissues. These cells express mRNA for the skeletal muscle specific transcription factor MyoD, the bone morphogenetic protein (BMP) inhibitor Noggin and the cell surface protein recognized by the G8 monoclonal antibody (m...
journal_title:Experimental eye research
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journal_title:Experimental eye research
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journal_title:Experimental eye research
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journal_title:Experimental eye research
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更新日期:1985-01-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
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journal_title:Experimental eye research
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doi:10.1016/0014-4835(86)90043-6
更新日期:1986-06-01 00:00:00
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journal_title:Experimental eye research
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更新日期:1987-06-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2010.02.006
更新日期:2010-05-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2011.09.015
更新日期:2011-12-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2006.05.005
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journal_title:Experimental eye research
pub_type: 杂志文章,评审
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2015.02.008
更新日期:2016-01-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/0014-4835(83)90043-x
更新日期:1983-04-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/s0014-4835(87)80002-7
更新日期:1987-02-01 00:00:00
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journal_title:Experimental eye research
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journal_title:Experimental eye research
pub_type: 杂志文章
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journal_title:Experimental eye research
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章,评审
doi:10.1016/j.exer.2017.02.005
更新日期:2017-04-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章,评审
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更新日期:2021-01-01 00:00:00
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journal_title:Experimental eye research
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journal_title:Experimental eye research
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doi:10.1016/j.exer.2009.02.006
更新日期:2009-06-15 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1006/exer.2001.1115
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2005.06.020
更新日期:2006-02-01 00:00:00