Linearization of human growth curves affords new classification of dwarfism.

abstract：:Lysosomes, lysosomal enzymes and oxidant processes are known to be involved in cancer processes. The prostasomes contain proteins and enzymes that would constitute pathways for the hydrolysis of proteins and peptides. However, integrated biochemical and cell biology studies are necessary to understand how lysosomal en...

journal_title：Medical hypotheses

authors： Tappel A

更新日期：2005-01-01 00:00:00

abstract：:Herbs and minerals are the integral parts of traditional systems of medicine in many countries. Kushta is a form of herbo-mineral preparations used in traditional systems of medicine (Unani and Ayurvedic) of Indo-Pak subcontinent. These preparations have long been used and claimed to be the most effective and potent d...

journal_title：Medical hypotheses

authors： Aziz N,Gilani AH,Rindh MA

更新日期：2002-10-01 00:00:00

abstract：:Unstable (CAG)n trinucleotide repeat microsatellites are hypothesized to cause schizophrenia. The (CAG)n microsatellite of dominant spinal cerebellar ataxia type 1 (SCA1) is a candidate schizophrenia gene. Autism results from expansions of (CGG)n and (GAA)n trinucleotide repeat stretches at fragile X syndrome (FRAXA),...

journal_title：Medical hypotheses

authors： Fischer KM

更新日期：1998-09-01 00:00:00

abstract：:Metformin, a drug widely used in the treatment of type II diabetes mellitus (T2DM), has been the focus of interest as a potential therapeutic agent for certain types of malignancies, including gynaecological cancers [i.e. endometrial cancer (EC)]. Although the exact mechanism behind the potential anticancer activity o...

journal_title：Medical hypotheses

authors： Karadeniz Z,Aynacıoğlu AŞ,Bilir A,Tuna MY

更新日期：2020-01-01 00:00:00

abstract：:NETosis, being an alternative form of cell death is the creation of web-like chromatin decondensates by suitably primed neutrophils as a response to stimulus aimed at containing and eliminating the same. In certain situations, it causes more harm than benefit in the form of bystander damage directly or via activation ...

journal_title：Medical hypotheses

authors： Gupta S,Sahni V

更新日期：2020-11-01 00:00:00

abstract：:Insulin resistance (IR) is a common denominator of metabolic and hemodynamic disorders simultaneously present in one person and responsible for elevated risk of developing type 2 diabetes (T2DM) and cardiovascular incidents. According to the latest research, IR is present in 25-45% of the general population. Therefore...

journal_title：Medical hypotheses

authors： Blaslov K,Kruljac I,Mirošević G,Kirigin Biloš LS,Vrkljan M

更新日期：2018-05-01 00:00:00

abstract：:The time of re-evaluation of the role of human immunodeficiency viruses in the pathogenesis of acquired immune deficiency syndrome has now come, now that methods are available for the direct detection of human immunodeficiency viruses and for the detection of cellular anti-human immunodeficiency virus immune reactions...

journal_title：Medical hypotheses

authors： Hässig A,Wen-Xi L,Stampfli K

更新日期：1996-04-01 00:00:00

abstract：:HIV may induce subclinical neuroendocrine dysfunctions in some seropositive patients and these dysfunctions may be one of the co-factors that determine the pathogenesis of AIDS. ...

journal_title：Medical hypotheses

authors： Salomon JC

更新日期：1988-09-01 00:00:00

abstract：:Seasonal affective disorder is defined as recurrent episodes of major depression, mania, or hypomania with seasonal onset and remission. In this class of mood disturbances, a unipolar major depressive disorder known as winter depression is common in populations living in northern latitudes far from the equator. Winter...

journal_title：Medical hypotheses

authors： Pereira JC Jr,Pradella Hallinan M,Alves RC

更新日期：2017-01-01 00:00:00

abstract：:Therapies for preventing reperfusion injury (RI) have been widely studied. However, the attempts to transfer cardioprotective therapies for reducing RI from experiments into clinical practice have been so far unsuccessful. Pathophysiological mechanisms of RI are complicated and compose of many pathways e.g. hypercontr...

journal_title：Medical hypotheses

authors： Barzyc A,Łysik W,Słyk J,Kuszewski M,Zarębiński M,Wojciechowska M,Cudnoch-Jędrzejewska A

更新日期：2020-04-01 00:00:00

abstract：:Pyoderma gangrenosum (PG) is a rare dermatological condition belonging to the group of deep neutrophilic dermatoses. It can display a protracted and refractory course. The list of treatments which have been tried and proved their efficacy is long, but none of them provide constant efficacy. In the absence of gold stan...

journal_title：Medical hypotheses

authors： Kluger N

更新日期：2012-05-01 00:00:00

abstract：:Treatment for stuttering attempts to reduce or eliminate the observable core markers of the disorder, specifically repetitions and prolongation. In this hypothesis, it is proposed that stuttering may be inhibited by two distinct yet related procedures: active inhibition and passive inhibition. Active inhibition is bro...

journal_title：Medical hypotheses

authors： Saltuklaroglu T,Dayalu VN,Kalinowski J

更新日期：2002-01-01 00:00:00

abstract：:A novel virus named 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) causes symptoms that are classified as coronavirus disease (COVID-19). Respiratory conditions are extensively described among more serious cases of COVID-19, and the onset of acute respiratory distress syndrome (ARDS) is one of the hallmark features of ...

journal_title：Medical hypotheses

authors： Geier MR,Geier DA

更新日期：2020-07-01 00:00:00

abstract：:The autoimmune disease rheumatoid arthritis (RA) presents difficulty in diagnosis, commonly observed flare ups, polycyclical nature of RA progression, and variable response to therapies. Congruent with multiple causes, literature has documented various infectious agents, environmental factors, physical trauma, silica ...

journal_title：Medical hypotheses

authors： Molnar-Kimber KL,Kimber CT

更新日期：2012-01-01 00:00:00

abstract：:The aim was to search for periodical fluctuations in daily occurrence of gout attacks during the synodic lunar cycle. 126 gout attacks were recorded between 1972 and 1994 at known calendar dates. The synodic plexogram, displaying the number of attacks for each day of the cycle, was processed by cosinor regression. A p...

journal_title：Medical hypotheses

authors： Mikulecký M,Rovenský J

更新日期：2000-07-01 00:00:00

abstract：:Synthetic ligands of the retinoid X receptor (RXR) have shown antidiabetic activity in mice, apparently owing to the fact that they stimulate the transcriptional activity of PPAR-gamma/RXR heterodimers, much like thiazolidinedione drugs. The chlorophyll metabolite phytanic acid has been shown to be a natural ligand fo...

journal_title：Medical hypotheses

authors： McCarty MF

更新日期：2001-02-01 00:00:00

abstract：:This novel, iso-osmo-resistive theory offers electro-resistivity of food components as a new dimension for digestion. Firstly, fats, carbohydrates and proteins differ markedly in their resistivity, which offers a way to monitor them, especially when digestive enzymes cause consistent and distinctive changes. Secondly ...

journal_title：Medical hypotheses

authors： Sutton JA

更新日期：2019-09-01 00:00:00

abstract：:One of the most commonly alleged contraindications to the use of (ethylene diamine tetraacetic acid) chelation therapy is possible renal damage. In this experiment, 13 subjects with chronic degenerative disorders and with renal damage were treated with infusions that included EDTA, vitamins, mineral and oral supplemen...

journal_title：Medical hypotheses

authors： Sehnert KW,Clague AF,Cheraskin E

更新日期：1984-11-01 00:00:00

abstract：:Local-regional relapse is the main recurrence pattern of the carcinoma in gut, and leads to poor prognosis. With the development of the total mesorectal and complete mesocolic excision (TME/CME), the local relapse rate of colorectal cancer has significantly decreased. People attributed it to the improvement of lymphad...

journal_title：Medical hypotheses

authors： Shen J,Xie D,Tong Y,Gong J

更新日期：2017-06-01 00:00:00

abstract：:Humans vary in the gene that encodes for Vitamin K epoxide reductase complex (VKORC1). Recent research has documented the protective effect of Vitamin K on neural cells and its role in maintaining normal neural development. Of interest, specific neural effects of Vitamin K overlap with key brain development aberration...

journal_title：Medical hypotheses

authors： DeSoto MC

更新日期：2016-11-01 00:00:00

abstract：:Many of the movement disorders seen in psychiatric patients are determined, in large part, by the dynamic balance of dopamine and acetylcholine in the basal ganglia. Gamma aminobutyric acid has effects on various neurotransmitters in the brain including dopamine and acetylcholine and is therefore relevant to a discuss...

journal_title：Medical hypotheses

authors： Menza M

更新日期：1988-12-01 00:00:00

abstract：:Intra-peritoneal adhesions ensuing from surgery or infection may lead to chronic pelvic pain, bowel obstruction, infertility and additional invasive surgery to resolve adhesion-related complications. As a result adhesions are a major clinical, social and economic concern. The cumulative year-on-year direct costs of ad...

journal_title：Medical hypotheses

authors： Sadek K,Macklon N,Bruce K,Cagampang F,Cheong Y

更新日期：2011-03-01 00:00:00

abstract：:An unacceptably high incidence of preterm labour is seen in the black and coloured communities of South Africa. This hypothesis proposes that sodium-potassium adenosine triphosphatase activity plays an important role in preterm labour. The impaired activity of the sodium pump leads to increased cytosolic calcium level...

journal_title：Medical hypotheses

authors： Du Toit PJ,Theron JJ,Grobler AS,Steinmann CM,Van Papendorp DH

更新日期：1996-09-01 00:00:00

abstract：:For a virus to survive and replicate in an organism, it must employ strategies to evade and misdirect the host's immune response. There is compelling evidence that the primary immunoevasive strategy utilized by the SARS virus, like influenza, is to inhibit its host's corticosteroid stress response. This is accomplishe...

journal_title：Medical hypotheses

authors： Wheatland R

更新日期：2004-01-01 00:00:00

abstract：:For a number of years, the principal attention was accorded total serum cholesterol as a possible predictor of cardiovascular pathosis. More recently, emphasis has been shifted to the high-density lipoproteins (HDL). Now consideration is turning to the ratio of total serum cholesterol to high-density lipoproteins. In ...

journal_title：Medical hypotheses

authors： McDonagh EW,Rudolph CJ,Cheraskin E

更新日期：1982-12-01 00:00:00

abstract：:Memory is a complex cognition that plays a critical role in daily functioning. This review discusses the dynamic effects of acute exercise on memory function, via a hypothesized exercise-memory interaction model, taking into consideration multiple memory systems and exercise parameters. ...

journal_title：Medical hypotheses

authors： Loprinzi PD

更新日期：2019-05-01 00:00:00

abstract：:Recurrent Aphthous Stomatitis (RAS) is the most common ulcerative diseases of oral mucosa affecting an estimate of 20% of the world's population. Majority of the people affected by RAS are under 30 years of age. RAS is located on the lining (non-keratinized) oral mucosa, i.e. buccal mucosa, lateral side of the tongue,...

journal_title：Medical hypotheses

authors： Pärssinen M,Jäsberg H,Mikkonen JJW,Kullaa AM

更新日期：2021-01-01 00:00:00

abstract：:The materno-fetal relationship is governed by critical levels of progesterone (P) and prostaglandin F2 alpha (PGF2 alpha). The 'see-saw' in concentration of these molecules maintain and terminate pregnancy in placental mammals. Apart from the enhancement or suppression of uterine contractility by PGF2 alpha and P resp...

journal_title：Medical hypotheses

authors： Pearson RD

更新日期：1980-10-01 00:00:00

abstract：:Anorexia nervosa was explored as the possible expression of an aberration of the processing of information which ordinarily has value in life protection or extension. Each of 6 areas was briefly reviewed, and noted to have the potential for failure to balance 2 or more factors. Anorexia nervosa may prove to be a psych...

journal_title：Medical hypotheses

authors： Spencer RP

更新日期：1990-09-01 00:00:00

abstract：:Acid hydrolysis of components from the diet in the stomach require the presence of an acid and a hydrolysing agent. The acid involved is hydrochloric acid. The present mechanism of hydrochloric acid production in the stomach is demonstrated to be incompatible with measured intracellular or intercellular concentrations...

journal_title：Medical hypotheses

authors： Robertson DS

更新日期：2005-01-01 00:00:00