Effect of oxidants and antioxidants on chromosomal breakage in Fanconi anemia lymphocytes.

Abstract:

:Peripheral blood lymphocytes from eight Fanconi anemia (FA) patients, 14 FA heterozygotes, and nine normal subjects have been tested for their susceptibility to chromosomal breakage induction by diepoxybutane (DEB) and by two peroxides. In addition, the effect of five antioxidants was investigated in standard cultures and in cultures stressed either with DEB or with butylhydroperoxide (BHP) or with hydrogen peroxide (H2O2). DEB, BHP, and H2O2 dramatically increased the chromosomal breakage levels in homozygous and heterozygous FA cells. A partial correction of chromosomal instability was obtained by treating the patients' lymphocytes with antioxidants. A "protective" effect was also noted in the DEB or peroxide-stressed lymphocytes of patients and heterozygotes, grown in the presence of antioxidants.

journal_name

Hum Genet

journal_title

Human genetics

authors

Dallapiccola B,Porfirio B,Mokini V,Alimena G,Isacchi G,Gandini E

doi

10.1007/BF00295530

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

62-5

issue

1

eissn

0340-6717

issn

1432-1203

journal_volume

69

pub_type

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