Ascorbic acid levels in aqueous and vitreous humors of the rabbit: effects of inflammation and ceruloplasmin.

abstract：:Rho GTPase regulated contractile signaling in the trabecular meshwork (TM) has been shown to modulate aqueous humor (AH) outflow and intraocular pressure (IOP). To explore whether elevated IOP, a major risk factor for primary open angle glaucoma (POAG) influences Rho GTPase signaling in the TM, we recorded AH outflow ...

journal_title：Experimental eye research

authors： Pattabiraman PP,Inoue T,Rao PV

更新日期：2015-07-01 00:00:00

abstract：:Utilizing cultured lenses from normal and homozygous glutathione peroxidase (GSHPx-1) knockout mice and inhibitors for GSSG Reductase (GSSG Red), 1,3-bis(2-chlorethyl)-1-nitrosourea (BCNU) and catalase (Cat), 3-aminotriazole (3-AT), the ability to degrade H2O2 was examined at two H2O2 concentrations, 300 microM and 80...

journal_title：Experimental eye research

authors： Spector A,Ma W,Wang RR,Yang Y,Ho YS

更新日期：1997-03-01 00:00:00

abstract：:microPx-11, a ferriheme undecapeptide proteolytic degradation product of cytochrome C is shown to be a peroxidase with broad specificity degrading H2O2 and tertiary butyl hydroperoxide. It is also capable of effectively eliminating superoxide and hydroxyl radical. The peroxidase loses activity in the presence of perox...

journal_title：Experimental eye research

authors： Spector A,Ma W,Wang RR,Kleiman NJ

更新日期：1997-10-01 00:00:00

abstract：:The development and growth of the vertebrate ocular lens is dependent on the regulated proliferation of an anterior monolayer of epithelial cells, and their subsequent differentiation into elongate fiber cells. The growth factor rich ocular media that bathes the lens mediates these cellular processes, and their respec...

journal_title：Experimental eye research

authors： Tam OH,Pennisi D,Wilkinson L,Little MH,Wazin F,Wan VL,Lovicu FJ

更新日期：2018-05-01 00:00:00

abstract：:Lens epithelium-derived growth factor (LEDGF) has been shown to enhance survival of lens epithelial cells (LECs) against stress. The objectives of these studies are to determine how LEDGF controls PKC gamma activity in normal LECs: how this control of PKC gamma regulates the phosphorylation of Connexin 43, the inhibit...

journal_title：Experimental eye research

authors： Nguyen TA,Boyle DL,Wagner LM,Shinohara T,Takemoto DJ

更新日期：2003-05-01 00:00:00

abstract：:Albino mice exposed to 1 X 10(-4) W cm-2 of UV radiation in the range 290-400 nm for 12 hr per day developed anterior lens opacities within 1-2 months after onset of the exposure. Histological changes demonstrated marked derangement of the lens epithelium. When the radiation was filtered with glass, eliminating radiat...

journal_title：Experimental eye research

authors： Jose JG,Pitts DG

更新日期：1985-10-01 00:00:00

abstract：:Intraocular pressure (IOP) is an important risk factor for glaucoma, and the response of the ONH and surrounding tissues to elevated IOP are often investigated to better understand pathophysiology. In vivo structure including that of the optic nerve head (ONH) and surrounding tissue of the eye are often assessed using...

journal_title：Experimental eye research

authors： Patel N,McAllister F,Pardon L,Harwerth R

更新日期：2018-04-01 00:00:00

abstract：:The similarities between glaucoma and mitochondrial optic neuropathies have driven a growing interest in exploring mitochondrial function in glaucoma. The specific loss of retinal ganglion cells is a common feature of mitochondrial diseases - not only the classic mitochondrial optic neuropathies of Leber's Hereditary ...

journal_title：Experimental eye research

authors： Lee S,Van Bergen NJ,Kong GY,Chrysostomou V,Waugh HS,O'Neill EC,Crowston JG,Trounce IA

更新日期：2011-08-01 00:00:00

abstract：:In our earlier study we showed that invasive retinoblastoma (RB) had down regulated tetraspanin protein KAI1/CD82, a family of cell surface glycoprotein. KAI1 may link to the cell surface molecules, such as integrins, E-cadherin, and other TM4SF members, and loss of KAI1 function may have a significant role in the pro...

journal_title：Experimental eye research

authors： Mohan A,Nalini V,Mallikarjuna K,Jyotirmay B,Krishnakumar S

更新日期：2007-04-01 00:00:00

abstract：:Previous evidence has shown clearly that sugar cataract formation results from unusually high intracellular levels of polyol. Documentation of polyol-related histological changes in the cortical fiber cells of the equatorial zone has been extensive. However, little attention has been given to the early changes in the ...

journal_title：Experimental eye research

authors： Robison WG Jr,Houlder N,Kinoshita JH

更新日期：1990-06-01 00:00:00

abstract：:Invagination of the optic vesicle to form the optic cup results in the formation of two apposed layers of neuroepithelium which follow divergent developmental pathways. Changes in the expression of cell surface molecules may be either the cause or result of important inductive signals during this process. We have used...

journal_title：Experimental eye research

authors： Neill JM,Barnstable CJ

更新日期：1990-11-01 00:00:00

abstract：:Limbal transplants in humans show a high rate of rejection even under local and systemic immunotherapy. In order to test immunomodulatory treatments a new limbal transplant model in the rat was developed using enhanced green fluorescent protein (E-GFP) as marker for follow-up. Sixty E-GFP-positive limbal transplants f...

journal_title：Experimental eye research

authors： Keijser S,de Keizer RJ,Prins FA,Tanke HJ,van Rooijen N,Vrensen GF,Jager MJ

更新日期：2006-11-01 00:00:00

abstract：:Immunocytochemistry with a monoclonal antibody against the 28-kDa calcium-binding protein (28-kDa CaBP) was used to study horizontal cells in both congenic control (RCS-rdy+) and dystrophic (RCS) 3-month-old rat retina. We found that horizontal cells in the RCS-rdy+ rat retinas were distributed evenly from the centre ...

journal_title：Experimental eye research

authors： Chu Y,Humphrey MF,Constable IJ

更新日期：1993-08-01 00:00:00

abstract：:The retinal pigment epithelium is a transporting epithelium that helps regulate the volume and composition of the subretinal space surrounding photoreceptor outer segments. The capacity of the RPE to actively transport Na+ and K+ between the retina and the blood supply depends on the localization of the Na+, K(+)-ATPa...

journal_title：Experimental eye research

authors： Defoe DM,Ahmad A,Chen W,Hughes BA

更新日期：1994-11-01 00:00:00

abstract：:Age-related Macular Degeneration (AMD) is the leading cause of visual impairment and blindness in the elderly in developed countries. Neovascular/exudative (wet) AMD is the aggressive form of AMD and can involve choroidal neovascularization and vascular leakage. Anti-vascular endothelial growth factor (anti-VEGF) medi...

journal_title：Experimental eye research

authors： Giddabasappa A,Lalwani K,Norberg R,Gukasyan HJ,Paterson D,Schachar RA,Rittenhouse K,Klamerus K,Mosyak L,Eswaraka J

更新日期：2016-04-01 00:00:00

abstract：:We have investigated the biochemical and cell biological basis of the reported beneficiary effects of the leaf extracts of the plant Ginkgo biloba, which has been used as a possible ophthalmic drug. The antioxidant, antimicrobial, anti-apoptotic and cytoprotective properties of the standardized extract called EGb761 w...

journal_title：Experimental eye research

authors： Thiagarajan G,Chandani S,Harinarayana Rao S,Samuni AM,Chandrasekaran K,Balasubramanian D

更新日期：2002-10-01 00:00:00

abstract：:The retinal pigment epithelium (RPE) is essential for maintaining the health of the neural retina. RPE cell dysfunction plays a critical role in many common blinding diseases including age-related macular degeneration (AMD), diabetic retinopathy, retinal dystrophies. Mouse models of ocular disease are commonly used to...

journal_title：Experimental eye research

authors： Wei H,Xun Z,Granado H,Wu A,Handa JT

更新日期：2016-04-01 00:00:00

abstract：:Glutamate is an excitatory neurotransmitter in the central and peripheral nervous systems of the vertebrate. The previous studies show the presence of mRNAs of AMPA-type glutamate receptors, GluR1 and GluR2, in the optic tectum of the pigeon, suggesting glutamatergic input from the retina. The present study examined l...

journal_title：Experimental eye research

authors： Islam MR,Atoji Y

更新日期：2009-09-01 00:00:00

abstract：:The human lens crystallin gene CRYGC T5P is associated with Coppock-like cataract and has a phenotype of a dust-like opacity of the fetal lens nucleus and deep cortical region. Previous in vitro mutation studies indicate that the protein has changed conformation, solubility, and stability, which may make it susceptibl...

journal_title：Experimental eye research

authors： Liu BF,Song S,Hanson M,Liang JJ

更新日期：2008-12-01 00:00:00

abstract：:The cornea receives the densest sensory innervation of the body, which is exclusively from small-fiber nociceptive (pain-sensing) neurons. These are similar to those in the skin of the legs, the standard location for neurodiagnostic skin biopsies used to diagnose small-fiber peripheral polyneuropathies. Many cancer ch...

journal_title：Experimental eye research

authors： Ferrari G,Nallasamy N,Downs H,Dana R,Oaklander AL

更新日期：2013-08-01 00:00:00

abstract：:This study was designed to determine the safety and efficacy of transferrin-ricin A chain toxin (Tfr-rRA) at preventing retinal detachment in a rabbit model of proliferative vitreoretinopathy (PVR). The toxicity of intravitreal Tfr-rRA (1000-5000 ng) was determined by indirect ophthalmoscopy and electroretinography on...

journal_title：Experimental eye research

authors： Handa JT,Keithahn MA,Jaffe GJ

更新日期：1996-06-01 00:00:00

abstract：:Transforming growth factor β (TGFβ) signaling is one of the most important signaling pathways regulating cell behavior in ocular tissues. Its functions are mainly linked to tissue fibrosis and inflammatory responses in ophthalmology. In epithelial cells, however, the growth inhibitory activity of TGFβ was reported in ...

journal_title：Experimental eye research

authors： Hu L,Pu Q,Zhang Y,Ma Q,Li G,Li X

更新日期：2019-05-01 00:00:00

abstract：:Mounting evidence suggests neuroinflammation is a key process in glaucoma, yet the precise roles are not known. Understanding these complex processes, which may also be a key in other common neurodegenerations such as Alzheimer's disease, will lead to targeted therapeutics for a disease that affects as many as 80 mill...

journal_title：Experimental eye research

authors： Williams PA,Marsh-Armstrong N,Howell GR,Lasker\/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants.

更新日期：2017-04-01 00:00:00

abstract：:By means of X-ray diffraction analysis, structural conversions of crystallins in human lens were detected in senile cataract and upon artificial dehydration of lens tissue. In senile cataract certain characteristics of the native three-dimensional structure of gamma- and beta-crystallins are completely lost, whereas d...

journal_title：Experimental eye research

authors： Krivandin AV,Lvov YuM,Ostrovski MA,Fedorovich IB,Feigin LA

更新日期：1989-11-01 00:00:00

abstract：:Purpose of the study was to develop and assess a novel controlled drug delivery system of latanoprost acid (LA). Poly(lactide)/Monomethoxy-poly(ethyleneglycol) (PLA-PEG) nanoparticles (NPs) were prepared using an emulsification-solvent evaporation technique. NPs were characterized in vitro according to their size, ζ-p...

journal_title：Experimental eye research

authors： Giarmoukakis A,Labiris G,Sideroudi H,Tsimali Z,Koutsospyrou N,Avgoustakis K,Kozobolis V

更新日期：2013-07-01 00:00:00

abstract：:The transport kinetics across the plasma-ocular barriers of labeled molecules including urea, D-glucose, 3-0-methyl-D-glucose, L-glucose, and sucrose were studied in adult RCS rats and compared to control albino Sprague-Dawleys (SD). Results indicate that substances that passively cross the plasma-aqueous and plasma-v...

journal_title：Experimental eye research

authors： DiMattio J,Zadunaisky JA

更新日期：1983-09-01 00:00:00

abstract：:Uncoupling protein 2 (UCP2) is a mitochondrial transporter present in the inner membrane of mitochondria, and it uncouples substrate oxidation from ATP synthesis, thereby dissipating the membrane potential energy and consequently decreasing ATP production by mitochondrial respiratory chain. As a consequence of the unc...

journal_title：Experimental eye research

authors： de Souza BM,Assmann TS,Kliemann LM,Marcon AS,Gross JL,Canani LH,Crispim D

更新日期：2012-01-01 00:00:00

abstract：:The retinal pigment epithelium (RPE) constitutes a monolayer of cuboidal cells that interact apically with the interphotoreceptor matrix (IPM) and outer segments of the photoreceptor cells and basally with the subjacent Bruch's membrane. This highly polarized structure is maintained by the cytoskeleton of individual c...

journal_title：Experimental eye research

authors： Bonilha VL

更新日期：2014-09-01 00:00:00

abstract：:The presence of the alpha(1)-adrenoceptor subtypes in various parts of the pig and rabbit eyes was investigated using [(3)H]-prazosin radioligand binding. The characterization of the subtypes was achieved by performing competition experiments with various subtype selective drugs. In the pig retina, both alpha(1A)- and...

journal_title：Experimental eye research

authors： Wikberg-Matsson A,Uhlén S,Wikberg JE

更新日期：2000-01-01 00:00:00

abstract：:Proliferative vitreoretinopathy (PVR) is a potentially blinding fibrotic complication. It is caused by the formation and contraction of epiretinal membranes (ERMs) that ultimately lead to retinal folds and traction retinal detachments. While multiple cell types have been identified in ERMs, retinal pigment epithelial ...

journal_title：Experimental eye research

authors： Tamiya S,Kaplan HJ

更新日期：2016-01-01 00:00:00