Abstract:
:A number of new 4(1H)-quinazolinones were synthesized and evaluated in the carrageenin-induced paw edema test. Most of the compounds were obtained by the cyclization of the appropriately substituted anthranilamides with acid chlorides, followed by further chemical transformation. Structure-activity data suggest that 2-isopropyl-1-phenyl-, 2-cyclopropyl-1-phenyl-, and 1-isopropyl-2-phenyl-4(1H)-quinazolinones afford optimal potency and the presence of a halogen atom is preferred for activity. Adrenalectomy does not affect the antiinflammatory test results. The best result taking into account both efficacy and side effects was displayed by 1-isopropyl-(2-fluorophenyl)-4-(1H)-quinazolinone (50).
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Ozaki K,Yamada Y,Oine T,Ishizuka T,Iwasawa Ydoi
10.1021/jm50001a006subject
Has Abstractpub_date
1985-05-01 00:00:00pages
568-76issue
5eissn
0022-2623issn
1520-4804journal_volume
28pub_type
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