Abstract:
:The pharmacokinetics of cephradine, a cephalosporin with a low degree of protein binding, was studied in 12 women after oral and intravenous administration of the drug during and after pregnancy. Six of the 12 women also received a cephalosporin with a high degree of protein binding, cefazolin, intravenously during and after pregnancy. For both drugs most pharmacokinetic parameters were altered in pregnancy. The area under the plasma concentration-time curve (AUC) following intravenous administration was smaller for both drugs during as compared to after pregnancy (mean change 39% for cephradine and 31% for cefazolin). Half-lives of both drugs were significantly shorter during compared with after pregnancy (mean change 26% for cephradine and 35% for cefazolin). Consequently, total body clearance was increased during pregnancy. A significant negative correlation between length of gestation and total clearance per kg bodyweight was seen for cephradine. The bioavailability of oral cephradine did not differ significantly during compared with after pregnancy. It is concluded that the dosage of both cefazolin and cephradine should be increased when treating infections in pregnant women in order to obtain the same antibacterial effect as when treating non-pregnant women.
journal_name
Clin Pharmacokinetjournal_title
Clinical pharmacokineticsauthors
Philipson A,Stiernstedt G,Ehrnebo Mdoi
10.2165/00003088-198712020-00004subject
Has Abstractpub_date
1987-02-01 00:00:00pages
136-44issue
2eissn
0312-5963issn
1179-1926journal_volume
12pub_type
杂志文章abstract:BACKGROUND:Febuxostat is a novel non-purine selective inhibitor of xanthine oxidase currently being developed for the management of hyperuricemia in patients with gout. OBJECTIVE:To investigate the pharmacokinetics, pharmacodynamics and safety of febuxostat over a range of oral doses in healthy subjects. METHODS:In a...
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abstract::A method is presented for the simultaneous estimation of functional hepatic blood flow and intrinsic clearance. The method uses pharmacokinetic data of a therapeutically employed drug and one of its primary metabolites following intravenous and oral administration of the parent compound. When the disposition of the dr...
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journal_title:Clinical pharmacokinetics
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journal_title:Clinical pharmacokinetics
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更新日期:1996-03-01 00:00:00
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更新日期:1983-03-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-01-01 00:00:00
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更新日期:2017-06-01 00:00:00
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journal_title:Clinical pharmacokinetics
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更新日期:1994-04-01 00:00:00
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journal_title:Clinical pharmacokinetics
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更新日期:2005-01-01 00:00:00
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更新日期:1994-06-01 00:00:00
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