Cellular gene induction during herpes simplex virus infection can occur without viral protein synthesis.

Abstract:

:Infection of cultured cells with herpes simplex virus (HSV) results in the transcriptional induction of a small number of cellular genes. Although the majority of such genes are dependent upon viral protein synthesis for their induction, a small minority are not. These genes are induced by events occurring prior to the onset of viral protein synthesis, in particular by binding of the virus to the cell surface and cellular entry of the virion. The significance of such cellular gene induction early in viral infection is discussed in terms of virus-cell interaction in general and the mechanism of transformation by HSV in particular.

journal_name

Nucleic Acids Res

journal_title

Nucleic acids research

authors

Kemp LM,Preston CM,Preston VG,Latchman DS

doi

10.1093/nar/14.23.9261

subject

Has Abstract

pub_date

1986-12-09 00:00:00

pages

9261-70

issue

23

eissn

0305-1048

issn

1362-4962

journal_volume

14

pub_type

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