Absence of degenerative changes in retinal and uveal capillary pericytes in diabetic rats.

abstract：PURPOSE:The accessory lacrimal glands are assumed to contribute to the production of tear fluid, but little is known about their function. The goal of this study was to conduct an analysis of gene expression by glands of Wolfring that would provide a more complete picture of the function of these glands. METHODS:Gland...

journal_title：Investigative ophthalmology & visual science

authors： Ubels JL,Gipson IK,Spurr-Michaud SJ,Tisdale AS,Van Dyken RE,Hatton MP

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Sildenafil (Viagra), a cGMP-specific phosphodiesterase type 5 inhibitor, is widely used for the treatment of erectile dysfunction and pulmonary hypertension. Clinical studies have reported transient visual impairments in patients after single-dose sildenafil use, suggesting neural involvement in several retinal...

journal_title：Investigative ophthalmology & visual science

authors： Martins J,Kolomiets B,Caplette R,Sahel JA,Castelo-Branco M,Ambrósio AF,Picaud S

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:To examine the expression of Angiotensin II (Ang II) and its type I, and type II receptors (AT1R, AT2R) in rabbit Tenon's capsule fibroblasts after trabeculectomy, and to investigate the effects of Ang II on cultured human Tenon's capsule fibroblasts (HTFs) proliferation, migration, phenotype transition, and ex...

journal_title：Investigative ophthalmology & visual science

authors： Shi H,Zhang Y,Fu S,Lu Z,Ye W,Xiao Y

更新日期：2015-01-06 00:00:00

abstract：PURPOSE:Elevated intraocular pressure (IOP), sensed as mechanical stretching by trabecular meshwork (TM) cells, triggers extracellular matrix (ECM) remodeling. In addition to changes in gene expression, alternative mRNA splicing may alter ECM protein isoforms. Changes in mRNA expression and alternative splicing of four...

journal_title：Investigative ophthalmology & visual science

authors： Keller KE,Kelley MJ,Acott TS

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To evaluate the developmental expression of Thy-1 in the retina. Thy-1, the most abundant mammalian neuronal surface glycoprotein, is likely to play a significant role in retinal development. In the mammalian retina, it is found predominantly, if not exclusively, on retinal ganglion cells. METHODS:Rat retinae ...

journal_title：Investigative ophthalmology & visual science

authors： Liu CJ,Chaturvedi N,Barnstable CJ,Dreyer EB

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:To study the effect of pars plana vitrectomy (PPV) on vitreous oxygenation (pO2) using magnetic resonance imaging (MRI). METHODS:Patients due to undergo PPV for either macular hole or epiretinal membrane were recruited. MRI scanning was performed 1 week before and at least 3 months after PPV. MRI T1 mapping wa...

journal_title：Investigative ophthalmology & visual science

authors： Simpson AR,Dowell NG,Jackson TL,Tofts PS,Hughes EH

更新日期：2013-03-21 00:00:00

abstract：PURPOSE:To determine whether the severity of glaucomatous damage in eyes with pseudoexfoliative (PEX) glaucoma is related to the amount of PEX material in the trabecular meshwork. METHODS:Trabecular meshwork and optic nerves from 19 eyes (11 donors) with PEX syndrome were studied. Eyes were chosen to represent all sta...

journal_title：Investigative ophthalmology & visual science

authors： Gottanka J,Flügel-Koch C,Martus P,Johnson DH,Lütjen-Drecoll E

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:To evaluate the efficiency of mitomycin C (MMC) in limiting the postoperative inflammatory response and scarring after strabismus surgery. METHODS:A prospective, two-stage, masked, controlled trial was conducted. In the first stage, the inflammatory response at the extraocular muscle reattachment site was incr...

journal_title：Investigative ophthalmology & visual science

authors： Minguini N,Monteiro de Carvalho KM,Akaishi PM,De Luca IM

更新日期：2000-10-01 00:00:00

abstract：:Postmitochondrial supernatant, cytosol, and microsomes were exposed to near-ultraviolet light and assayed for incorporation of (3H)leucine. The results indicate that near-ultraviolet light decreased the incorporation of radioactivity into the aminoacyl-tRNA fraction and into proteins. This effect depended on the wavel...

journal_title：Investigative ophthalmology & visual science

authors： Matuk Y,Lou P,Parker JA

更新日期：1977-12-01 00:00:00

abstract：PURPOSE:Adhesion molecules play a critical role in leukocyte emigration to wound sites, but differences are evident in different vascular beds. In this study, the contributions of P-selectin to neutrophil emigration into the cornea after central epithelial abrasion were investigated. METHODS:Re-epithelialization, neut...

journal_title：Investigative ophthalmology & visual science

authors： Li Z,Rumbaut RE,Burns AR,Smith CW

更新日期：2006-11-01 00:00:00

abstract：Purpose:Diabetes leads to the downregulation of the retinal Kir4.1 channels and Müller cell dysfunction. The insulin receptor substrate-1 (IRS-1) is a critical regulator of insulin signaling in Müller cells. Circadian rhythms play an integral role in normal physiology; however, diabetes leads to a circadian dysrhythmia...

journal_title：Investigative ophthalmology & visual science

authors： Luo Q,Xiao Y,Alex A,Cummins TR,Bhatwadekar AD

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To evaluate the functional treatment response 3 months and 12 months after monthly ranibizumab in neovascular age-related macular degeneration (NAMD). METHODS:Twenty-six eyes showing treatment-naïve NAMD were examined with the Heidelberg Spectralis OCT (SD-OCT) and the Nidek MP-1 microperimeter (MP) at baselin...

journal_title：Investigative ophthalmology & visual science

authors： Sulzbacher F,Kiss C,Kaider A,Roberts P,Munk M,Kroh ME,Sayegh R,Schmidt-Erfurth U

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:To assess if the in vivo mechanical displacement of the anterior laminar cribrosa surface (ALCS) as a response of an acute elevation in intraocular pressure (IOP) differs in individuals of European (ED) and African descent (AD). METHODS:Spectral-domain optical coherence tomography (SDOCT) scans were obtained f...

journal_title：Investigative ophthalmology & visual science

authors： Fazio MA,Johnstone JK,Smith B,Wang L,Girkin CA

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:To investigate functional interactions between the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and the nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant system in cultured human retinal pigment epithelium (RPE) cells. METHODS:Cultured ARPE-19 cells were treated with different concen...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Chen Y,Sternberg P,Cai J

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:To identify factors associated prospectively with increased cataract surgical rate (CSR) in rural Chinese hospitals. METHODS:Annual cataract surgical output was obtained at baseline and 24 months later from operating room records at 42 rural, county-level hospitals. Total local CSR (cases/million population/y)...

journal_title：Investigative ophthalmology & visual science

authors： Chen T,Jin L,Zhou Z,Huang Y,Yan X,Liu T,Ong EL,Liu B,Huang W,Iezzi B,He M,Friedman DS,Congdon NG

更新日期：2015-02-03 00:00:00

abstract：:The authors used a psychophysical method to measure lens transmission of young, type I diabetic patients and normal controls. The results from normal controls agreed with previously published reports of decreasing lens transmission with age, and those from diabetic subjects suggested that lenses of young, type I diabe...

journal_title：Investigative ophthalmology & visual science

authors： Lutze M,Bresnick GH

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To assess vascular endothelial function in patients with normal pressure glaucoma using forearm blood flow responses to intra-arterial infusions of endothelial-dependent and -independent vasoactive agents. METHODS:Eight patients with newly diagnosed and untreated normal pressure glaucoma and eight healthy age-...

journal_title：Investigative ophthalmology & visual science

authors： Henry E,Newby DE,Webb DJ,O'Brien C

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:To evaluate the consequences of altering retinal sterol metabolism and composition on the development, histologic organization, and electrophysiological function of the retina, under conditions that mimic the biochemical hallmarks of the Smith-Lemli-Opitz (SLO) syndrome. METHODS:Pregnant Sprague-Dawley rats we...

journal_title：Investigative ophthalmology & visual science

authors： Fliesler SJ,Richards MJ,Miller C,Peachey NS

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:Doxorubicin chemomyectomy presently represents the only permanent, nonsurgical treatment for blepharospasm and hemifacial spasm. The major deterrent to an otherwise extremely effective treatment protocol is the development in patients of localized inflammation, discomfort, and skin injury over the injection sit...

journal_title：Investigative ophthalmology & visual science

authors： McLoon LK,Wirtschafter JD

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:To investigate whether the detection of apoptosing retinal cells (DARC) could detect cells undergoing apoptosis in a laser model of retinal damage. METHODS:Laser lesions were placed, with the use of a frequency-doubled Nd:YAG laser, on the retina in 34 eyes of anesthetized Dark Agouti rats. Lesion size and las...

journal_title：Investigative ophthalmology & visual science

authors： Schmitz-Valckenberg S,Guo L,Maass A,Cheung W,Vugler A,Moss SE,Munro PM,Fitzke FW,Cordeiro MF

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:To evaluate the immunosuppressive and antiangiogenic activities of an intraocular rapamycin (RAPA) drug delivery system (DDS) in a rabbit model of high-risk penetrating keratoplasty. METHODS:Forty New Zealand White rabbits with corneal neovascularization underwent allograft cornea transplantation and were rand...

journal_title：Investigative ophthalmology & visual science

authors： Shi W,Gao H,Xie L,Wang S

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:Fibroblast growth factor-binding proteins (FGF-BPs) have been identified recently in blood and other biologic fluids and have been shown to be identical to a truncated form of the high-affinity cell surface FGF receptor. The authors examined the hypothesis that FGF-BPs also are present in human vitreous fluid. ...

journal_title：Investigative ophthalmology & visual science

authors： Hanneken A,Baird A

更新日期：1995-05-01 00:00:00

abstract：:Purpose. Super-selective intra-ophthalmic artery chemotherapy (SSIOAC) is an eye-targeted drug-delivery strategy to treat retinoblastoma, the most prevalent primary ocular malignancy in children. Unfortunately, recent clinical reports associate adverse vascular toxicities with SSIOAC using melphalan, the most commonly...

journal_title：Investigative ophthalmology & visual science

authors： Steinle JJ,Zhang Q,Thompson KE,Toutounchian J,Yates CR,Soderland C,Wang F,Stewart CF,Haik BG,Williams JS,Jackson JS,Mandrell TD,Johnson D,Wilson MW

更新日期：2012-04-30 00:00:00

abstract：PURPOSE:To determine whether messenger RNA coding for fibroblast growth factor receptor-1, interleukin-1 receptor, and glucocorticoid receptor messenger RNA are produced in human lacrimal tissue. METHODS:Total cellular RNA was isolated from three specimens of normal human lacrimal tissue and complementary DNA was synt...

journal_title：Investigative ophthalmology & visual science

authors： Wilson SE,Lloyd SA,Kennedy RH

更新日期：1993-05-01 00:00:00

abstract：PURPOSE:To examine changes in spherical equivalent over a 5-year period in persons 43 to 84 years of age. METHODS:All people 43 to 84 years of age and living in Beaver Dam, Wisconsin, in 1988 were invited for a baseline examination (1988-1990) and a 5-year follow-up examination (1993-1995). Refractions were determined...

journal_title：Investigative ophthalmology & visual science

authors： Lee KE,Klein BE,Klein R

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:Conventional time-domain optical coherence tomography (OCT) has been shown to provide reproducible retinal nerve fiber layer (RNFL) measurements. Recently, high-speed, high-resolution Fourier-domain 3D-OCT has been introduced to improve OCT quality. It can provide 6-mm(2) high-density scans to provide RNFL thic...

journal_title：Investigative ophthalmology & visual science

authors： Menke MN,Knecht P,Sturm V,Dabov S,Funk J

更新日期：2008-12-01 00:00:00

abstract：Purpose:To determine whether combining quantitative optical coherence tomography angiography (OCTA) parameters can achieve high sensitivity and specificity to distinguish eyes with nonproliferative diabetic retinopathy (NPDR) from those with proliferative diabetic retinopathy (PDR) as well as eyes with diabetes and no ...

journal_title：Investigative ophthalmology & visual science

authors： Ashraf M,Nesper PL,Jampol LM,Yu F,Fawzi AA

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:Cannabinoids have been reported to mediate changes in vascular resistance through endothelial receptor targets. We examined involvement of the endothelium in cannabinoid-mediated vasoactive responses in resistance arterioles of the retina. METHODS:Vascular responses to both intraluminal (IL) and extraluminal (...

journal_title：Investigative ophthalmology & visual science

authors： Su EN,Kelly ME,Cringle SJ,Yu DY

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:To determine the metrics of vertical saccades in elderly subjects for comparison in neurologic disease. METHODS:Sixteen elderly subjects, ten middle-aged subjects, and thirteen young subjects were examined using a magnetic search coil technique. Saccades were measured to predictable vertical target steps and m...

journal_title：Investigative ophthalmology & visual science

authors： Huaman AG,Sharpe JA

更新日期：1993-07-01 00:00:00

abstract：PURPOSE:Connexin50 (Cx50) is absolutely essential for normal postnatal lens growth. Deletion of Cx50 or replacement with Cx46 by knockin resulted in smaller lenses containing fewer cells. To determine why Cx50-deficient lenses fail to grow normally, cell proliferation was assayed during the period of growth failure. M...

journal_title：Investigative ophthalmology & visual science

authors： Sellitto C,Li L,White TW

更新日期：2004-09-01 00:00:00