Abstract:
:An investigation of the stereospecificity of beta-adrenergic insulin release, its relation to alpha-adrenergic blockade and the adrenergic innervation of the pancreatic islets was performed in the mouse. It was observed that in vivo beta-adrenergic stimulation of insulin release by isopropylnoradrenaline was stereospecific for the L-stereoisomer and selectively blocked by the L-isomer of the beta-adrenergic antagonist L-propranolol. D-propranolol had no effect. Pretreatment of mice with a dose of D-isopropylnoradrenaline devoid of insulin releasing activity, slightly increased the subsequent insulin response to a half-maximal dose of L-isopropylnoradrenaline. Basal insulin secretion was blocked by L-propranolol (beta-adrenergic blockade) and increased by phentolamine (alpha-adrenergic blockade). A beta-blocked insulin response to L-isopropyl-noradrenaline could be overcome by alpha-adrenergic blockade depending on the dose of the beta-agonist, suggesting a close association between the adrenergic receptors. The adrenergic innervation of the islet cells was studied by electron microscopic autoradiography after injection of 3H-L-noradrenaline. It was observed that labelled adrenergic nerve terminals were associated with both A1- (D-), A2- and B-cells. The nerves were mainly distributed in the periphery of the islets either as single axons or as bundles. The majority of the terminals were associated with A2-cells, the most frequent cell type in the islet periphery. However, in all islets examined terminals were found close to B-cells. Adrenergic terminals often caused indentations in the contour of an islet cell and were separated from the islet cell membrane only by a narrow intercellular space, about 20 nm in width. It is concluded that the islet cells of the mouse are equipped with the morphological substrate for direct adrenergic regulation. Further it is suggested that the B-cell is supplied with L-stereospecific beta-adrenergic receptors and that the alpha- and beta-adrenergic receptors are at least partially interrelated.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Lundquist I,Ericson LEdoi
10.1007/BF00221602subject
Has Abstractpub_date
1978-10-06 00:00:00pages
73-85issue
1eissn
0302-766Xissn
1432-0878journal_volume
193pub_type
杂志文章abstract::The structure of the two integumental layers comprising the carapace of female D. magna was examined at several points through the molt cycle. The epicuticle and procuticle are simple in organisation; pore canalsare absent but intracuticular fibres are present, forming complexes with invaginations of the epidermal pla...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214213
更新日期:1976-06-14 00:00:00
abstract::Affinity of lymphoid cells for the microenvironment of germinal centers (GC), as detectable in transfer experiments by rapid homing in spleen GC from the blood, is a capacity expressed by only a subset of lymphoid cells, in particular by those constituting a GC. However, when introduced into the blood stream, these ce...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00215160
更新日期:1984-01-01 00:00:00
abstract::Removal of the somatic DNA methylation pattern from donor cells and remodeling of embryonic status have been suggested as integral processes for successful nuclear transfer (NT) reprogramming. This study has investigated the effects of 5-azacytidine (5-azaC), a DNA methylation inhibitor, on global methylation changes ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-006-0201-9
更新日期:2006-09-01 00:00:00
abstract::Many noctuid moth species perceive ultrasound via tympanic ears that are located at the metathorax. Whereas the neural processing of auditory information is well studied at the peripheral and first synaptic level, little is known about the features characterizing higher order sound-sensitive neurons in the moth brain....
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1749-9
更新日期:2014-02-01 00:00:00
abstract::The intestine, which is exposed to nutrition and to food-derived antigens and microbes including viruses and bacteria, might be an important site for the immune response. Crucial structural and functional differences exist between the small and large intestine, regional differences even having been demonstrated within...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-003-0706-4
更新日期:2003-07-01 00:00:00
abstract::We present an experimental method allowing the production of three-dimensional organ-like structures, namely microtissues (MTs), in vitro without the need for exogenous extracellular matrix (ECM) or growth factors. Submandibular salivary glands (embryonic day ED14), kidneys (ED13) and lungs (ED13) were harvested from ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-016-2487-6
更新日期:2016-12-01 00:00:00
abstract::The monoamines octopamine and tyramine, which are the invertebrate counterparts of epinephrine and norepinephrine, transmit their action through sets of G protein-coupled receptors. Four different octopamine receptors (Oamb, Octß1R, Octß2R, Octß3R) and 3 different tyramine receptors (TyrR, TyrRII, TyrRIII) are present...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-015-2137-4
更新日期:2015-09-01 00:00:00
abstract::Urocortin (UCN) is a 40-amino-acid peptide and a member of the corticotropin-releasing hormone (CRH) family, which includes CRH, urotensin I, sauvagine, UCN2 and UCN3. The biological actions of CRH family peptides are mediated via two types of G-protein-coupled receptors, namely CRH type 1 receptor (CRHR1) and CRH typ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-012-1450-4
更新日期:2012-10-01 00:00:00
abstract::Neurointermediate lobes from adult or 10-day-old rats were implanted by a stereotaxic procedure into the third ventricle of adult male rats, in an area close to the paraventricular nucleus. They were examined, using immunocytochemical and ultrastructural techniques, at times ranging from 1 week to 8 months. All grafts...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00224123
更新日期:1989-02-01 00:00:00
abstract::The motility patterns of the reticulorumen evoke mainly mixing of the ingesta. So far unknown, intrinsic neural circuits of the enteric nervous system are involved in the control of these motility patterns. The aim of the study was to characterize neurochemically sheep ruminal myenteric neurones, in particular the neu...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-002-0554-7
更新日期:2002-09-01 00:00:00
abstract::Exposure of adult brown bullheads Ictalurus nebulosus (120-450 g) to environmental hypercapnia (2% carbon dioxide in air) and subsequent recovery caused transient changes in whole body net sodium flux (JnetNa+) and net chloride flux (JnetCl-) resulting largely from changes in whole body sodium influx (JNa+in) and chlo...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00319161
更新日期:1992-06-01 00:00:00
abstract::In the compound eye of the locust, Locusta, the cross-sectional area of the rhabdoms increases at "dusk" by 4.7-fold due to the rapid assembly of new microvillar membrane, and decreases at "dawn" by a corresponding amount as a result of pinocytotic shedding from the microvilli. The rhabdoms at night have more and long...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214807
更新日期:1982-01-01 00:00:00
abstract::Expression of the non-muscle myosin heavy chain-B (NM-MHC-B, also denoted as the embryonic smooth muscle myosin heavy chain, SMemb) was examined in rat urinary bladder during growth in response to a partial urinary outflow obstruction. Following obstruction, the weight of the urinary bladder increased more than five-f...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410000262
更新日期:2001-05-01 00:00:00
abstract::The submandibular gland (SMG) is a tissue that can be regenerated in a tissue injury model and that has adult stem cells capable of self-renewal and differentiation into functional cells. We have analyzed the localization of label-retaining cells (LRCs), which are putative progenitor cells, by using the BrdU-labeling ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-008-0667-8
更新日期:2008-10-01 00:00:00
abstract::Golgi- and fluorescence-histochemical studies in the chicken shown the presence of a sharply delimited group of aminergic neurons beneath the floor of the fourth ventricle at the mesen-metencephalic boundary. According to the observations reported in other avian species a homology can be established between the mammal...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216221
更新日期:1982-01-01 00:00:00
abstract::Colonies of the ascidian Botryllus schlosseri undergo recurrent generation changes in which adult zooids are gradually resorbed and replaced by new blastogenic generations. During these periods, known as take-over phases, programmed cell death, which, on the basis of morphological analysis is ascribed to apoptosis, oc...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-003-0738-9
更新日期:2003-06-01 00:00:00
abstract::A recently developed immunohistochemical technique for serotonin (Steinbusch et al. 1978) was used in the present investigation to study the occurrence of this indoleamine in the granulated epithelial cells of neuro-epithelial bodies (NEB). Lungs from neonatal rabbits and pigs exhibit immunoreactive cell groups identi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00217095
更新日期:1982-01-01 00:00:00
abstract::In the compound eye of Notonecta glauca, the backswimmer, there is a small ventral region in which the rhabdoms differ in structure from those in the other parts of the eye. Here, among other unusual features, there is a special orientation of the microvilli of the central rhabdomeres, i.e., in most of the median eye ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00222373
更新日期:1983-01-01 00:00:00
abstract::The extracellular matrix is involved in various morphogenetic processes which are accompanied by changes in its physicochemical properties and spatial organization. In the adult brain it contributes to cellular communication and the regulation of neuronal activity. The present study deals with the postnatal appearance...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s004410050790
更新日期:1997-04-01 00:00:00
abstract::The innervation pattern of distal muscle fibers of the opener muscle of walking legs of crayfish (Astacus leptodactylus) was investigated using methylene-blue staining, cobalt infiltration, and electron microscopy. A quantitative analysis of the entire innervation of single muscle fibers was attempted. It was found th...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00213750
更新日期:1982-01-01 00:00:00
abstract::Brains and subesophageal ganglia from day 3.5 fifth stadium larvae of Manduca sexta were incubated in vitro with 4 nM tritiated ponasterone A, a 20-hydroxyecdysone analog, to determine whether uptake and specific binding of ecdysteroids occur at a cellular level. These tissues, which were taken just prior to the commi...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00318414
更新日期:1991-01-01 00:00:00
abstract::Rab11, a small monomeric GTPase associated with recycling endosomes, is a key molecule in the regulation of vesicular trafficking and is involved in the development and differentiation of many Drosophila tissues through interaction with diverse signaling pathways. In this study, we report for the first time that Rab11...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-016-2500-0
更新日期:2017-02-01 00:00:00
abstract::By use of the immunofluorescence technique TSH-, LH- and ACTH-cells were localized in the hypophysis of tadpoles of Xenopus laevis. The first signs of the activity of these cells were observed in early stages of the development, i.e., stage 39 for ACTH, and stage 42 for TSH and LH. ...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00216218
更新日期:1982-01-01 00:00:00
abstract::Four forms of short neuropeptide F (sNPF1-4), derived from the gene snpf, have been identified in Drosophila and are known to act on a single G-protein-coupled receptor (sNPFR). Several functions have been suggested for sNPFs in Drosophila, including the regulation of feeding and growth in larvae, the control of insul...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-013-1660-4
更新日期:2013-09-01 00:00:00
abstract::The aluminium-formaldehyde (ALFA) histofluorescence method was used to study the innervation of the gill of the marine bivalve mollusc Mytilus edulis and the results were contrasted with those obtained with the standard formaldehyde-induced-fluorescence (FIF) method. The ALFA method produced more fluorescing structure...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00214696
更新日期:1982-01-01 00:00:00
abstract::We have recently reported that Sox2-expressing pituitary stem/progenitor cells contact each other via a tight-junction protein CAR to form stem/progenitor cell niches in the marginal cell layer facing the lumen and in the clusters scattered in the parenchyma of the anterior lobe. However, the microenvironment of the n...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-014-2054-y
更新日期:2015-03-01 00:00:00
abstract::The present study continues a previous investigation on the median eminence (EM) (Krisch et al., 1978). In rats with high levels of neurohormones (LHRH, vasopressin) a limited immunohistochemical labeling of perivascular tanycyte processes can be observed surrounding capillaries in the marginal region of the organum v...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/BF00233891
更新日期:1978-12-29 00:00:00
abstract::Kainate receptors form a family of ionotropic glutamate receptors that appear to play a special role in the regulation of the activity of synaptic networks. This review first describes briefly the molecular and pharmacological properties of native and recombinant kainate receptors. It then attempts to outline the gene...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-006-0265-6
更新日期:2006-11-01 00:00:00
abstract::Tight junctions (TJ) between retinal pigmented epithelial (RPE) and retinal endothelial cells maintain the outer and inner blood-retinal barrier, and the breakdown of these barriers is associated with retinal diseases. Vascular endothelial growth factor (VEGF) increases vascular permeability and is thought to be invol...
journal_title:Cell and tissue research
pub_type: 杂志文章
doi:10.1007/s00441-005-0046-7
更新日期:2006-01-01 00:00:00
abstract::Serine proteases, cysteine proteases, aspartic proteases and matrix metalloproteinases play an essential role in extracellular matrix remodeling and turnover through their proteolytic action on collagens, proteoglycans, fibronectin, elastin and laminin. Proteases can also act on chemokines, receptors and anti-microbia...
journal_title:Cell and tissue research
pub_type: 杂志文章,评审
doi:10.1007/s00441-012-1390-z
更新日期:2013-02-01 00:00:00