Evaluation of monoclonal antifibrin antibodies by their binding to human blood clots.

abstract：:Atrial fibrillation (AF) is a common complication of coronary artery bypass grafting (CABG). We sought to determine the diagnostic validity of plasma biomarkers of i) inflammation (marked by interleukin-6 [IL-6] and high-sensitivity C-reactive protein [hs-CRP]), ii) extracellular matrix remodelling (matrix metalloprot...

journal_title：Thrombosis and haemostasis

authors： Kaireviciute D,Blann AD,Balakrishnan B,Lane DA,Patel JV,Uzdavinys G,Norkunas G,Kalinauskas G,Sirvydis V,Aidietis A,Lip GY

更新日期：2010-07-01 00:00:00

abstract：:Risk scores in patients with atrial fibrillation (AF) based on clinical factors alone generally have only modest predictive value for predicting high risk patients that sustain events. Biomarkers might be an attractive prognostic tool to improve bleeding risk prediction. The new ABC-Bleeding score performed better tha...

journal_title：Thrombosis and haemostasis

authors： Esteve-Pastor MA,Rivera-Caravaca JM,Roldan V,Vicente V,Valdés M,Marín F,Lip GYH

更新日期：2017-10-05 00:00:00

abstract：:Hirudin is a potent thrombin inhibitor derived from the leech Hirudo medicinalis salivary gland which has considerable potential for therapeutic use in thrombotic disease. The major risk attendant its use is hemorrhage. This study investigates the hypothesis that the prohemostatic effects of DDAVP infusion can curtail...

journal_title：Thrombosis and haemostasis

authors： Bove CM,Casey B,Marder VJ

更新日期：1996-03-01 00:00:00

abstract：:The simultaneous additon of suboptimal concentrations of factor VIII and intact or plasmin-lysed fibrinogen into mixtures of the vitamin K dependent factors, phospholipids, adsorbed bovine serum (supplier to factor V) and calcium, increased the amount of thrombin which was generated three to twenty times over the sum ...

journal_title：Thrombosis and haemostasis

authors： Triantaphyllopoulos DC,Ryan LT

更新日期：1976-04-30 00:00:00

abstract：:A native fucosylated glycosaminoglycan from sea cucumber Holothuria fuscopunctata (nHG), mainly branched with Fuc3S4S, exhibited potent anticoagulant activity by intrinsic tenase iXase (FIXa-FVIIIa complex) and antithrombin-dependent factor IIa (FIIa) inhibition, but also had the effects of FXII activation and platele...

journal_title：Thrombosis and haemostasis

authors： Zhou L,Gao N,Sun H,Xiao C,Yang L,Lin L,Yin R,Li Z,Zhang H,Ji X,Zhao J

更新日期：2020-04-01 00:00:00

abstract：:An algal sulfated galactan has high anticoagulant and antithrombotic activities. Its serpin-dependent anticoagulant action is due to promoting thrombin and factor (F)Xa inhibition by antithrombin and heparin cofactor II. Here, we evaluated the anticoagulant effect of the algal sulfated galactan using serpin-free plasm...

journal_title：Thrombosis and haemostasis

authors： Glauser BF,Rezende RM,Melo FR,Pereira MS,Francischetti IM,Monteiro RQ,Rezaie AR,Mourão PA

更新日期：2009-12-01 00:00:00

abstract：:Alpha-enolase is an ubiquitous cytoplasmic glycolytic enzyme which also exhibits cell surface mediated functions and a structural role in the lens of some species. An alpha-enolase related molecule (alpha-ERM) is present on the surfaces of neutrophils, monocytes and monocytoid cells and has the capacity to specificall...

journal_title：Thrombosis and haemostasis

authors： Arza B,Félez J,Lopez-Alemany R,Miles LA,Muñoz-Cánoves P

更新日期：1997-09-01 00:00:00

abstract：:The Asian population is thought to have a low risk of venous thromboembolism (VTE), but the epidemiology of VTE in cancer patients remains unclear. The National Health Insurance Research Database of Taiwan was used to find hospitalised patients newly-diagnosed with cancer to determine the incidence of VTE in cancer pa...

journal_title：Thrombosis and haemostasis

authors： Yu YB,Gau JP,Liu CY,Yang MH,Chiang SC,Hsu HC,Hong YC,Hsiao LT,Liu JH,Chiou TJ,Chen PM,Lee TS,Chou LF,Tzeng CH,Chen TJ

更新日期：2012-08-01 00:00:00

abstract：:Our previous study has shown that Toll-like receptor 4 (TLR4) and its signalling pathway contribute to anti-β₂-glycoprotein I/β₂-glycoprotein I (anti-β₂GPI/β₂GPI)-induced tissue factor (TF) expression in human acute monocytic leukaemia cell line THP-1 and annexin A2 (ANX2) is involved in this pathway. However, its dow...

journal_title：Thrombosis and haemostasis

authors： Xu G,Wen H,Zhou H,Guo D,Zhou F,Chen D,Xie H,Wang T,Wang H

更新日期：2011-12-01 00:00:00

abstract：:The efficiency of current dual antiplatelet therapy might be further improved by its combination with a glycoprotein (GP) VI-targeting strategy without increasing bleeding. GPVI-Fc, a recombinant dimeric fusion protein binding to plaque collagen and concealing binding sites for platelet GPVI, acts as a lesion-focused ...

journal_title：Thrombosis and haemostasis

authors： Mojica Muñoz AK,Jamasbi J,Uhland K,Degen H,Münch G,Ungerer M,Brandl R,Megens R,Weber C,Lorenz R,Siess W

更新日期：2017-08-01 00:00:00

abstract：:Hemolytic uremic syndrome (HUS), the leading cause of acute renal failure in children (< 3 years), is mainly related to Shiga toxins (Stx)-producing Escherichia coli (STEC) infections. STEC are confined to the gut resulting in hemorrhagic colitis, whereas Stx are delivered in blood to target kidney and brain, with unc...

journal_title：Thrombosis and haemostasis

authors： Brigotti M,He X,Carnicelli D,Arfilli V,Porcellini E,Galassi E,Tazzari PL,Ricci F,Patfield SA,Testa S,Paglialonga F,Picicco D,Caprioli A,Scavia G,Morabito S,Ardissino G

更新日期：2020-01-01 00:00:00

abstract：:We have previously reported that platelets from bleeding Simmental cattle do not aggregate in vitro in response to ADP, collagen and calcium ionophore A23187, though calcium mobilization and myosin light chain phosphorylation do occur. The aggregation abnormality, measured by aggregometry, was ascribed to abnormal cyt...

journal_title：Thrombosis and haemostasis

authors： Frojmovic MM,Wong T,Searcy GP

更新日期：1996-12-01 00:00:00

abstract：:Congenital amegakaryocytic thrombocytopaenia (CAMT) is a disorder caused by c-MPL mutations that impair thrombopoietin (TPO) signalling, resulting in a near absence of megakaryocytes (MKs). While this phenotype is consistent in adults, neonates with CAMT can present with severe thrombocytopaenia despite normal MK numb...

journal_title：Thrombosis and haemostasis

authors： Lorenz V,Ramsey H,Liu ZJ,Italiano J Jr,Hoffmeister K,Bihorel S,Mager D,Hu Z,Slayton WB,Kile BT,Sola-Visner M,Ferrer-Marin F

更新日期：2017-12-01 00:00:00

abstract：:Over the last few years methods have been developed to assess appearance of thrombin during blood clotting in a clinical setting. This can be achieved either by measurement of the specific thrombin markers or by analysis of the thrombin generation kinetics. Thrombin markers rise following coronary occlusion and, surpr...

journal_title：Thrombosis and haemostasis

authors： Szczeklik A

更新日期：1995-07-01 00:00:00

abstract：:In the last decade, several studies revealed inter-patient response variability to antiplatelet agents: patients who display negligible or no responses to these drugs are considered poor responders, or "resistant" to treatment. In order to identify poor responders to an antiplatelet drug, laboratory tests of platelet ...

journal_title：Thrombosis and haemostasis

authors： Cattaneo M

更新日期：2013-05-01 00:00:00

abstract：:To find if there is a relation between levels of haemostatic variables at low and high hormonal levels (oestradiol and progesterone) in an individual, blood samples were drawn from 12 women repeatedly during one menstrual cycle (Study I) and from 14 women undergoing in vitro fertilization, before hormonal stimulation ...

journal_title：Thrombosis and haemostasis

authors： Andersson O,Blombäck M,Bremme K,Wramsby H

更新日期：1997-05-01 00:00:00

abstract：:The effect of chronic administration of ethanol to rats in a controlled regimen upon the activities of the coagulation factors II, VII, VIII, IX and X has been studied. No significant differences were found for factor II, IX and X between the ethanol-treated rats and the control group given an isocaloric diet with car...

journal_title：Thrombosis and haemostasis

authors： Morland J,Holm T,Prydz H

更新日期：1976-12-31 00:00:00

abstract：:Monocytes play a central role in the inflammatory disease atherosclerosis. CD14+CD16+ monocytes are considered proinflammatory monocytes, as they have an increased capacity to produce proinflammatory cytokines, such as TNF-alpha, and are elevated in various inflammatory diseases. We hypothesized that patients with cor...

journal_title：Thrombosis and haemostasis

authors： Schlitt A,Heine GH,Blankenberg S,Espinola-Klein C,Dopheide JF,Bickel C,Lackner KJ,Iz M,Meyer J,Darius H,Rupprecht HJ

更新日期：2004-08-01 00:00:00

abstract：:Enhanced adhesion of sickle erythrocytes to the vascular endothelium and subendothelial matrix is fundamental to the development of vascular occlusion in sickle cell disease. Erythrocyte membrane sulfatide is implicated in the pathogenesis of vasoocclusive crises in sickle cell disease (SCD) patients. Because previous...

journal_title：Thrombosis and haemostasis

authors： Zhou Z,Thiagarajan P,Udden M,Lòpez JA,Guchhait P

更新日期：2011-06-01 00:00:00

abstract：:We investigated the protective effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of factor Xa, against two kinds of experimental disseminated intravascular coagulation (DIC) in rats. Endotoxin-induced experimental DIC was induced by a 4-h sustained infusion of endotoxin at a dose of 100 m...

journal_title：Thrombosis and haemostasis

authors： Yamazaki M,Asakura H,Aoshima K,Saito M,Jokaji H,Uotani C,Kumabashiri I,Morishita E,Ikeda T,Matsuda T

更新日期：1994-09-01 00:00:00

abstract：:The core protein components of the plasminogen activator (PA) system are two plasminogen activators, two plasminogen activator inhibitors and a urokinase type plasminogen activator-specific cell surface receptor. Various types of biological regulation are exerted through the interplay of these components mutually and ...

journal_title：Thrombosis and haemostasis

authors： Nagamine Y,Medcalf RL,Muñoz-Cánoves P

更新日期：2005-04-01 00:00:00

abstract：:Positively charged macromolecule, polylysine (mol. wt. 15,000; 23,000; 180,000) could induce the platelet aggregation in low concentration but high concentration was required in the case of neutral macromolecule, dextran (mol. wt. 40,000; 250,000; 2,000,000). The larger molecules of polylysine and dextran were more ef...

journal_title：Thrombosis and haemostasis

authors： Taketomi Y,Kuramoto A

更新日期：1978-08-31 00:00:00

abstract：:Microparticles (MPs) are formed from platelets (PMPs), endothelial cells (EMPs) and monocytes (MMPs), and in acute myocardial infarction (MI), there is an increase of MPs in the culprit artery. In this study MPs were evaluated in whole blood in 105 patients with MI at five time-points during a two-year follow-up (FU)....

journal_title：Thrombosis and haemostasis

authors： Christersson C,Thulin Å,Siegbahn A

更新日期：2017-07-26 00:00:00

abstract：:Platelets are suggested to play a crucial role in cancer progression and the prothrombotic state of cancer patients. Here, we aimed to examine the activation status of platelets in cancer patients and investigate their association with risk of death and occurrence of venous thromboembolism (VTE) in a prospective obser...

journal_title：Thrombosis and haemostasis

authors： Riedl J,Kaider A,Marosi C,Prager GW,Eichelberger B,Assinger A,Pabinger I,Panzer S,Ay C

更新日期：2017-01-05 00:00:00

abstract：:Worldwide, haemophilia is the most common hereditary bleeding disorder. The incidence of haemophilia B, however, is considerably less than haemophilia A and consequently appears to have received less attention in the research literature. This article aims to summarise the available evidence documenting the patient and...

journal_title：Thrombosis and haemostasis

authors： Gater A,Thomson TA,Strandberg-Larsen M

更新日期：2011-09-01 00:00:00

abstract：:In order to determine the molecular size of human F VIII as found in fresh plasma and as found in fresh-frozen plasma and in cryoprecipitate and to study the relationship of the factor-related properties, namely F VIII:C, F VIIR:Rcof and F VIIIR:Ag to F VIII, the factor's elution pattern on Sephacryl 1000 was investig...

journal_title：Thrombosis and haemostasis

authors： Vukovich TC

更新日期：1982-08-24 00:00:00

abstract：:The urinary excretion rate of antithrombin III related antigen (AT III RA) was examined in cerebral stroke. The excretion rate of AT III RA in cerebral hemorrhage (CH) was 12.33 +/- 1.61 X 10(-4) ml/min. The patients with CH were further classified into two groups: in group CH-I, whose consciousness state was stupor o...

journal_title：Thrombosis and haemostasis

authors： Matsuo T,Shinomiya K,Okuno S,Matsuo C,Matsuo O

更新日期：1984-12-29 00:00:00

abstract：:Assembly of fibronectin into the provisional fibrillar matrix of embryonic tissues and wounds is a complicated process by which the intracellular cytoskeleton determines the pattern of assembly of extracellular matrix and vice versa. Assembly is restricted to dimeric fibronectin molecules with intact N-terminal module...

journal_title：Thrombosis and haemostasis

authors： Mosher DF

更新日期：1995-07-01 00:00:00

abstract：:Among the nine ellagitannins, rugosin E was the most potent platelet aggregating agent with an EC50 of 1.5 +/- 0.1 microM in rabbit platelets and 3.2 +/- 0.1 microM in human platelets. The aggregations caused by rugosin E and ADP were inhibited by EGTA, PGE1, mepacrine, sodium nitroprusside and neomycin, but not by in...

journal_title：Thrombosis and haemostasis

authors： Teng CM,Kang YF,Chang YL,Ko FN,Yang SC,Hsu FL

更新日期：1997-03-01 00:00:00

abstract：:In patients with von Willebrand disease (VWD) replacement therapy with factor VIII/von Willebrand (VWF) concentrates is increasingly applied as prophylactic regimen. Since 2000, 82 consecutively enrolled patients with clinically relevant bleeding episodes (spontaneous, peri- or postoperative) were diagnosed with VWD [...

journal_title：Thrombosis and haemostasis

authors： Halimeh S,Krümpel A,Rott H,Bogdanova N,Budde U,Manner D,Faeser B,Mesters R,Nowak-Göttl U

更新日期：2011-04-01 00:00:00