Native surface association of a recombinant 38-kilodalton Treponema pallidum antigen isolated from the Escherichia coli outer membrane.

abstract：:Endotoxin-treated mice exhibit a rapid rise in the level of the serum amyloid A (SAA) protein, but this effect is not observed in endotoxin-resistant C3H/HeJ mice. To evaluate the role of lymphoid cells in the production of SAA protein, C3H/HeJ mice were adoptively transfused with endotoxin-sensitive (C3H/HeN) bone ma...

journal_title：Infection and immunity

authors： Rosenstreich DL,McAdam KP

更新日期：1979-01-01 00:00:00

abstract：:Macrophages are among the most sensitive targets of bacterial endotoxin (LPS), responding to minute amounts of LPS by releasing a battery of inflammatory mediators. Transfection of macrophages with secretory leukocyte protease inhibitor (SLPI) renders these cells refractory to LPS stimulation. Here we show that uptake...

journal_title：Infection and immunity

authors： Ding A,Thieblemont N,Zhu J,Jin F,Zhang J,Wright S

更新日期：1999-09-01 00:00:00

abstract：:Subtilase cytotoxin (SubAB) is a recently identified AB5 subunit toxin produced by Shiga-toxigenic Escherichia coli. The A subunit is thought to be a subtilase-like, serine protease, whereas the B subunit binds to the toxin receptor on the cell surface. We cloned the genes from a clinical isolate; the toxin was produc...

journal_title：Infection and immunity

authors： Morinaga N,Yahiro K,Matsuura G,Watanabe M,Nomura F,Moss J,Noda M

更新日期：2007-01-01 00:00:00

abstract：:Group A streptococci (GAS) are highly prevalent human pathogens whose primary ecological niche is the superficial epithelial layers of the throat and/or skin. Many GAS strains with a strong tendency to cause pharyngitis are distinct from strains that tend to cause impetigo; thus, genetic differences between them may c...

journal_title：Infection and immunity

authors： Rouchon CN,Ly AT,Noto JP,Luo F,Lizano S,Bessen DE

更新日期：2017-10-18 00:00:00

abstract：:Ribosomes of strain NOR-7 of group B Neisseria meningitidis were isolated by a procedure that included treatment of the cells with sodium dodecyl sulfate, disruption in a French pressure cell, and differential centrifugation. These preparations consisted of 66% ribonucleic acid and 24% protein and sedimented as a sing...

journal_title：Infection and immunity

authors： Thomas DW,Weiss E

更新日期：1972-09-01 00:00:00

abstract：:Staphylococcus aureus is a prominent human pathogen and a leading cause of community- and hospital-acquired bacterial infections worldwide. Herein, we describe the identification and characterization of the S. aureus 67.6-kDa hypothetical protein, named for the surface factor promoting resistance to oxidative killing ...

journal_title：Infection and immunity

authors： Malachowa N,Kohler PL,Schlievert PM,Chuang ON,Dunny GM,Kobayashi SD,Miedzobrodzki J,Bohach GA,Seo KS

更新日期：2011-01-01 00:00:00

abstract：:Immune and pathologic responses were measured for 20 weeks after infection of mice with Brucella abortus 19, RB51, or 2308. Live bacteria and bacterial antigens of 19 and RB51 persisted in spleens for 10 and 4 weeks after infection, respectively, whereas 2308 bacteria and bacterial antigens persisted for at least 20 w...

journal_title：Infection and immunity

authors： Stevens MG,Olsen SC,Pugh GW Jr,Palmer MV

更新日期：1994-08-01 00:00:00

abstract：:Disruption of the healthy intestinal microbiome and homeostasis of the intestinal immune system, which are closely interactive, are two key factors for ulcerative colitis. Here, we show that MI-2, a selective inhibitor of mucosa-associated lymphoid tissue lymphoma translocation-1 (MALT1), alleviated excessive inflamma...

journal_title：Infection and immunity

authors： Lee KW,Kim M,Lee CH

更新日期：2018-11-20 00:00:00

abstract：:Lipid X, a precursor in the biosynthesis of lipid A, has been claimed to possess most of the immunostimulatory activity but none of the toxicity of endotoxin. However, recent work shows that synthetic lipid X can be contaminated with small amounts of N,O-acylated disaccharide-1-phosphate (H. Aschauer, A. Grob, J. Hild...

journal_title：Infection and immunity

authors： Lam C,Hildebrandt J,Schütze E,Rosenwirth B,Proctor RA,Liehl E,Stütz P

更新日期：1991-07-01 00:00:00

abstract：:A genomic library of meningococcal DNA from a clinical isolate of Neisseria meningitidis was constructed in the expression vector lambda gt11. Outer membrane complex was prepared from the same strain and used to immunize rabbits to raise polyclonal anti-outer membrane complex serum. The amplified library was probed wi...

journal_title：Infection and immunity

authors： Barlow AK,Heckels JE,Clarke IN

更新日期：1987-11-01 00:00:00

abstract：:Using fluorescent antibody techniques (FA) and light microscopy (LM) and electron microscopy (EM), this paper describes the morphological features of the ileum in the DK1 mouse orally challenged with adenovirus K87. At the peak of infection, virus is easily identified by FA in the epithelium of the villi and crypts of...

journal_title：Infection and immunity

authors： Takeuchi A,Hashimoto K

更新日期：1976-02-01 00:00:00

abstract：:The interaction between bacteria and fibronectin is believed to play an important role in the pathogenicity of clinically important Gram-positive cocci. In the present study, we identified a gene encoding a predicted fibronectin-binding protein of Enterococcus faecium (fnm), a homologue of Streptococcus pneumoniae pav...

journal_title：Infection and immunity

authors： Somarajan SR,La Rosa SL,Singh KV,Roh JH,Höök M,Murray BE

更新日期：2015-12-01 00:00:00

abstract：:As an opportunistic bacterial pathogen, Pseudomonas aeruginosa mainly affects immunocompromised individuals as well as patients with cystic fibrosis. In a previous study, we showed that ExoS of P. aeruginosa, when injected into host cells through a type III secretion apparatus, functions as an effector molecule to tri...

journal_title：Infection and immunity

authors： Jia J,Alaoui-El-Azher M,Chow M,Chambers TC,Baker H,Jin S

更新日期：2003-06-01 00:00:00

abstract：:Helicobacter pylori colonizes the gastric mucosa and secretes a pore-forming toxin (VacA). Two main types of VacA, m1 and m2, can be distinguished by phylogenetic analysis. Type m1 forms of VacA have been extensively studied, but there has been relatively little study of m2 forms. In this study, we generated H. pylori...

journal_title：Infection and immunity

authors： Caston RR,Sierra JC,Foegeding NJ,Truelock MD,Campbell AM,Frick-Cheng AE,Bimczok D,Wilson KT,McClain MS,Cover TL

更新日期：2020-05-20 00:00:00

abstract：:The unpredictable nature of bioterrorism and the absence of real-time detection systems have highlighted the need for an efficient postexposure therapy for Bacillus anthracis infection. One approach is passive immunization through the administration of antibodies that mitigate the biological action of anthrax toxin. W...

journal_title：Infection and immunity

authors： Albrecht MT,Li H,Williamson ED,LeButt CS,Flick-Smith HC,Quinn CP,Westra H,Galloway D,Mateczun A,Goldman S,Groen H,Baillie LW

更新日期：2007-11-01 00:00:00

abstract：:Human polymorphonuclear leukocytes from normal subjects produced proinflammatory cytokines in response to stimulation with Cryptococcus neoformans yeast cells. The cytokines released after stimulation of neutrophils included interleukin-1beta (IL-1beta), IL-6, IL-8 and tumor necrosis factor alpha. The magnitude of the...

journal_title：Infection and immunity

authors： Retini C,Vecchiarelli A,Monari C,Tascini C,Bistoni F,Kozel TR

更新日期：1996-08-01 00:00:00

abstract：:The reproducibility of an experimental result is a fundamental assumption in science. Yet, results that are merely confirmatory of previous findings are given low priority and can be difficult to publish. Furthermore, the complex and chaotic nature of biological systems imposes limitations on the replicability of scie...

journal_title：Infection and immunity

authors： Casadevall A,Fang FC

更新日期：2010-12-01 00:00:00

abstract：:The extracellular cysteine protease from Streptococcus pyogenes is a virulence factor that plays a significant role in host-pathogen interaction. Streptococcal protease is expressed as an inactive 40-kDa precursor that is autocatalytically converted into a 28-kDa mature (active) enzyme. Replacement of the single cyste...

journal_title：Infection and immunity

authors： Matsuka YV,Pillai S,Gubba S,Musser JM,Olmsted SB

更新日期：1999-09-01 00:00:00

abstract：:A receptor specific for lipoglycans from Acholeplasma axanthum and Acholeplasma granularum was isolated from sheep erythrocyte stroma by extraction with n-pentanol and permeation chromatography. The purified receptor appeared as one band on sodium dodecyl sulfate-polyacrylamide gels and stained with Coomassie blue, pe...

journal_title：Infection and immunity

authors： Al-Samarrai TH,Smith PF,Lynn RJ

更新日期：1982-12-01 00:00:00

abstract：:Shigella flexneri 2a is an invasive enteric pathogen that may produce diarrhea when ingested by human beings and subhuman primates. We have previously shown that shigella diarrhea correlates with water and electrolyte transport abnormalities in the jejunum and colon. Dysentery alone is associated only with colonic tra...

journal_title：Infection and immunity

authors： Kinsey MD,Formal SB,Dammin GJ,Giannella RA

更新日期：1976-08-01 00:00:00

abstract：:Whooping cough results from infection of the respiratory tract with Bordetella pertussis, and the secreted adenylate cyclase toxin (ACT) is essential for the bacterium to establish infection. Despite extensive study of the mechanism of ACT cytotoxicity and its effects over a range of concentrations in vitro, ACT has n...

journal_title：Infection and immunity

authors： Eby JC,Gray MC,Warfel JM,Paddock CD,Jones TF,Day SR,Bowden J,Poulter MD,Donato GM,Merkel TJ,Hewlett EL

更新日期：2013-05-01 00:00:00

abstract：:Candida albicans secreted aspartyl proteinases (Saps) are considered virulence-associated factors. Several members of the Sap family were claimed to play a significant role in the progression of candidiasis established by the hematogenous route. This assumption was based on the observed attenuated virulence of sap-nul...

journal_title：Infection and immunity

authors： Correia A,Lermann U,Teixeira L,Cerca F,Botelho S,da Costa RM,Sampaio P,Gärtner F,Morschhäuser J,Vilanova M,Pais C

更新日期：2010-11-01 00:00:00

abstract：:Menstrually associated toxic shock syndrome (TSS) is attributed primarily to the effects of staphylococcal exotoxin toxic shock syndrome toxin 1 (TSST-1). A region of the 194-amino-acid toxin spanning residues 115 through 144 constitutes a biologically active site. Several point mutations in the TSST-1 gene in that re...

journal_title：Infection and immunity

authors： Bonventre PF,Heeg H,Cullen C,Lian CJ

更新日期：1993-03-01 00:00:00

abstract：:The surface coat of Trypanosoma brucei, formed by about 10(7) molecules of the membrane-form variant surface glycoprotein (mfVSG) per cell, is generally considered to constitute a barrier against the access of antibodies directed to invariant surface proteins. The recent characterization of two invariant surface glyco...

journal_title：Infection and immunity

authors： Ziegelbauer K,Overath P

更新日期：1993-11-01 00:00:00

abstract：:Serotype b-specific polysaccharide antigen (SPA) was extracted from whole cells of Actinobacillus actinomycetemcomitans Y4 by autoclaving and purified by chromatography on DEAE-Sephadex A-25 and Sephacryl S-300. SPA induced the release of monocyte and leukocyte chemotactic factors by human monocytes. Polymyxin B had a...

journal_title：Infection and immunity

authors： Yamaguchi N,Yamashita Y,Ikeda D,Koga T

更新日期：1996-07-01 00:00:00

abstract：:Antiprotein monoclonal antibodies derived from mice inoculated with Rickettsia rickettsii heated at 56 degrees C for 15 min are of two types: one is type specific for epitopes denatured by moderate temperatures, and the other is specific for epitopes resistant to 100 degrees C for 5 min. The heat-resistant epitopes ar...

journal_title：Infection and immunity

authors： Anacker RL,McDonald GA,List RH,Mann RE

更新日期：1987-03-01 00:00:00

abstract：:A cytotoxin was found in culture filtrates of a number of Escherichia coli strains that differed from the known heat-stable and heat-labile enterotoxins of E. coli. It was cytotoxic for Vero but not for Y-1 or CHO cells, and its effect on Vero was distinctly different from that of heat-labile enterotoxin. It was labil...

journal_title：Infection and immunity

authors： Konowalchuk J,Speirs JI,Stavric S

更新日期：1977-12-01 00:00:00

abstract：:An enhanced memory response, as shown by increased titers of specific immunoglobulin A (IgA), was seen in intestinal secretions from isolated Thiry-Vella loops in rabbits primed orally with live, locally invasive Shigella sp. X16 and challenged 60 days later with a single oral dose of the same antigen. Heat-killed shi...

journal_title：Infection and immunity

authors： Keren DF,McDonald RA,Scott PJ,Rosner AM,Strubel E

更新日期：1985-01-01 00:00:00

abstract：:Peptidoglycan from a Staphylococcus epidermidis strain, isolated from a patient with septicemia, was preincubated with human serum. This mixture was then investigated for its potency to induce tumor necrosis factor (TNF) secretion by human blood monocytes. TNF was measured in the supernatants by using a bioassay and/o...

journal_title：Infection and immunity

authors： Mattsson E,Rollof J,Verhoef J,Van Dijk H,Fleer A

更新日期：1994-09-01 00:00:00

abstract：:The ethanol-insoluble product formed from sucrose by purified enzyme encoded by the gtfA gene from Streptococcus mutans, expressed in recombinant Escherichia coli, was analyzed by 13C and 31P nuclear magnetic resonance. The product was identified as alpha-D-glucose-1-phosphate, and it was concluded that the GTF-A enzy...

journal_title：Infection and immunity

authors： Russell RR,Mukasa H,Shimamura A,Ferretti JJ

更新日期：1988-10-01 00:00:00