The interaction of activated protein C and thrombin with the plasminogen activator inhibitor released from human endothelial cells.

abstract：:The efficacy and safety of dabigatran for treatment of venous thromboembolism (VTE) were demonstrated in two trials. It is unclear if the results pertain to patients with cancer and VTE. Data from two randomised trials comparing dabigatran and warfarin for acute VTE were pooled. Primary efficacy outcome was symptomati...

journal_title：Thrombosis and haemostasis

authors： Schulman S,Goldhaber SZ,Kearon C,Kakkar AK,Schellong S,Eriksson H,Hantel S,Feuring M,Kreuzer J

更新日期：2015-07-01 00:00:00

abstract：:Fibrinogen degradation products formed by the action of purified haemolymph and saliva of a Saturnidae caterpillar of the Lonomia genus were studies by immunoelectrophoresis and polyacrylamide/SDS gel electrophoresis. The pattern of degradation differ form the one described for plasmin, trypsin, brinase, and ochrase. ...

journal_title：Thrombosis and haemostasis

authors： Arocha-Piñango CL,Perales J,Carvajal Z

更新日期：1981-06-30 00:00:00

abstract：:We examined the effect of a synthetic thrombin inhibitor, MCI-9038, on two experimental animal models of disseminated intravascular coagulation (DIC). In a model that DIC induced by the intravenous infusion of thrombin, MCI-9038 suppressed the decrease of platelet count by about 50% at a dose of 0.2 micrograms/kg/min ...

journal_title：Thrombosis and haemostasis

authors： Hara H,Tamao Y,Kikumoto R,Okamoto S

更新日期：1987-04-07 00:00:00

abstract：:Tissue-type plasminogen activator (t-PA) is a fibrin-specific agent which is used to treat acute myocardial infarction. Pharmacokinetically, t-PA is characterized by a rapid clearance from the circulation. In a previous study, we constructed variant forms of t-PA with genetic modifications at the fibronectin finger-li...

journal_title：Thrombosis and haemostasis

authors： Yahara H,Matsumoto K,Maruyama H,Nagaoka T,Ikenaka Y,Yajima K,Fukao H,Ueshima S,Matsuo O

更新日期：1994-12-01 00:00:00

abstract：:Thromboembolism remains a serious problem in patients with prosthetic heart valves. Previous studies documented a number of platelet abnormalities in such patients and correlated the occurrence of thromboembolic complications with short platelet survival. We have studied platelet survival and platelet aggregation in e...

journal_title：Thrombosis and haemostasis

authors： Al-Mondhiry H,Pierce WS,Richenbacher W

更新日期：1984-10-31 00:00:00

abstract：:Neuroserpin is a member of the serine proteinase inhibitor (serpin) gene family that reacts preferentially with tissue-type plasminogen activator (tPA) and is primarily localized to neurons in regions of the brain where tPA is also found. Outside of the central nervous system (CNS) tPA is predominantly found in the bl...

journal_title：Thrombosis and haemostasis

authors： Yepes M,Lawrence DA

更新日期：2004-03-01 00:00:00

abstract：:Extracellular RNA (eRNA), released from cells under conditions of injury or vascular disease, acts as potent prothrombotic factor and promotes vascular hyperpermeability related to oedema formation in vivo. In this study, we aimed to investigate the mechanism by which eRNA triggers inflammatory processes, particularl...

journal_title：Thrombosis and haemostasis

authors： Fischer S,Grantzow T,Pagel JI,Tschernatsch M,Sperandio M,Preissner KT,Deindl E

更新日期：2012-10-01 00:00:00

abstract：:Recombinant factor VIIa (rFVIIa: NovoSeven; Novo Nordisk) has proven efficacy in the treatment of haemophilic patients with inhibitors. This prospective, double-blind study compared rFVIIa (35 vs. 90 microg/kg) in the initiation and maintenance of haemostasis during and after elective surgery. Patients with inhibitors...

journal_title：Thrombosis and haemostasis

authors： Shapiro AD,Gilchrist GS,Hoots WK,Cooper HA,Gastineau DA

更新日期：1998-11-01 00:00:00

abstract：:Central venous access devices are often essential for the administration of chemotherapy to patients with malignancy, but its use has been associated with a number of complications, mainly thrombosis. The true incidence of upper extremity deep vein thrombosis (DVT) in this setting is difficult to estimate since there ...

journal_title：Thrombosis and haemostasis

authors： Monreal M,Alastrue A,Rull M,Mira X,Muxart J,Rosell R,Abad A

更新日期：1996-02-01 00:00:00

abstract：:A recent report indicated that an arrow poison used by the native Indians of Rondonia, Brazil, to kill small animals was associated with profuse bleeding. The arrow poison was prepared from the bark of a tree, known locally as Tike-Uba. We have obtained bark and sap specimens from this tree and have characterized a po...

journal_title：Thrombosis and haemostasis

authors： Jacobs JW,Petroski C,Friedman PA,Simpson E

更新日期：1990-02-19 00:00:00

abstract：:Lysyl oxidase (LOX) is an extracellular matrix-modifying enzyme that seems to play a critical role in vascular remodelling. However, the lack of viable LOX-deficient animal models has been an obstacle to deep in LOX biology. In this study we have developed a transgenic mouse model that over-expresses LOX in vascular s...

journal_title：Thrombosis and haemostasis

authors： Orriols M,Guadall A,Galán M,Martí-Pàmies I,Varona S,Rodríguez-Calvo R,Briones AM,Navarro MA,de Diego A,Osada J,Martínez-González J,Rodríguez C

更新日期：2014-10-01 00:00:00

abstract：:We studied the role of various markers of lipid metabolism, hemostasis and inflammation in a two year follow-up of 3,000 patients with angina pectoris, during which time 106 patients experienced myocardial infarction or sudden coronary death. Low levels of high density lipoprotein (HDL) cholesterol and of apolipoprote...

journal_title：Thrombosis and haemostasis

authors： Bolibar I,von Eckardstein A,Assmann G,Thompson S,ECAT Angina Pectoris Study Group. European Concerted Action on Thrombosis and Disabilities.

更新日期：2000-12-01 00:00:00

abstract：:The leech protein hirudin is a potent inhibitor of thrombin, but clinical use of recombinant hirudin is restricted by haemorrhagic risks, and complicated by hirudin's rapid clearance from the circulation. We previously employed albumin fusion to slow hirudin variant 3 (HV3) clearance. In this study, we hypothesized th...

journal_title：Thrombosis and haemostasis

authors： Sheffield WP,Eltringham-Smith LJ,Gataiance S,Bhakta V

更新日期：2009-05-01 00:00:00

abstract：:Recent prospective studies indicate endothelial dysfunction and increased risk for cardiovascular events in patients with serological evidence of multiple infections. Soluble CD14 (sCD 14) plays a key role in the neutralization of lipopolysaccharide (LPS), a well-established bacterial product inducing endothelial dysf...

journal_title：Thrombosis and haemostasis

authors： Fernández-Real JM,López-Bermejo A,Castro A,Broch M,Peñarroja G,Vendrell J,Vázquez G,Ricart W

更新日期：2005-09-01 00:00:00

abstract：:The activation of factor XI by meizothrombin was investigated using recombinant meizothrombin (R155A meizothrombin) that is resistant to autocatalytic removal of fragment 1. Meizothrombin was capable of activating factor XI at an activation rate similar to that of thrombin. Dextran sulphate and heparin, known cofactor...

journal_title：Thrombosis and haemostasis

authors： von dem Borne PA,Mosnier LO,Tans G,Meijers JC,Bouma BN

更新日期：1997-08-01 00:00:00

abstract：:Much research in venous thrombotic diseases focuses on the acute thrombotic process such as anticoagulation and risk factors. Deep-vein thrombosis directly leads to post thrombotic syndrome, and this can cause significant patient disability. Little research has focused on the vein wall injury response to the thromboti...

journal_title：Thrombosis and haemostasis

authors： Deroo S,Deatrick KB,Henke PK

更新日期：2010-10-01 00:00:00

abstract：:Current biochemical markers of thrombosis, such as d-dimer, are of little value in demonstrating the presence of thrombus postoperatively, as their levels are elevated by surgery. Thrombosis involves adhesive interactions between the endothelium, platelets and leukocytes. The aim of the study was to determine which of...

journal_title：Thrombosis and haemostasis

authors： Smith A,Quarmby JW,Collins M,Lockhart SM,Burnand KG

更新日期：1999-12-01 00:00:00

abstract：:Hyperhomocysteinemia is a risk factor of venous thromboembolism. The risk of recurrence in patients with hyperhomocysteinemia is unknown, and the optimal therapy for these patients after acute venous thromboembolism is uncertain. In a multicenter study, 264 patients with an objectively documented single episode of idi...

journal_title：Thrombosis and haemostasis

authors： Eichinger S,Stümpflen A,Hirschl M,Bialonczyk C,Herkner K,Stain M,Schneider B,Pabinger I,Lechner K,Kyrle PA

更新日期：1998-10-01 00:00:00

abstract：:A high throughput 384-well plate assay of blood function in 60 microl reactions with the fluorogenic thrombin substrate, boc-VPR-MCA, allowed for real-time monitoring of coagulation under a diverse set of reaction conditions. Using recalcified, citrated whole blood diluted 3-fold with corn trypsin inhibitor (to block ...

journal_title：Thrombosis and haemostasis

authors： Lo K,Diamond SL

更新日期：2004-10-01 00:00:00

abstract：:The clinical severity in some patients with haemophilia A appears to be unrelated to the levels of factor (F)VIII activity (FVIII:C), but mechanisms are poorly understood. We have investigated a patient with a FVIII gene mutation at Arg1781 to His (R1781H) presenting with a mild phenotype despite FVIII:C of 0.9 IU/dl....

journal_title：Thrombosis and haemostasis

authors： Yada K,Nogami K,Wakabayashi H,Fay PJ,Shima M

更新日期：2013-06-01 00:00:00

abstract：:Heme oxygenase-1 (HO-1) decreases apoptosis, inflammation and oxidative stress. The aim of the study was to investigate the effects of intracoronary infusion of allogenic bone marrow cells (BMC) overexpressing HO-1 in the porcine model of myocardial infarction (MI). MI was produced by balloon occlusion of a coronary a...

journal_title：Thrombosis and haemostasis

authors： Wojakowski W,Tendera M,Cybulski W,Zuba-Surma EK,Szade K,Florczyk U,Kozakowska M,Szymula A,Krzych L,Paslawska U,Paslawski R,Milewski K,Buszman PP,Nabialek E,Kuczmik W,Janiszewski A,Dziegiel P,Buszman PE,Józkowicz A,D

更新日期：2012-09-01 00:00:00

abstract：:Mechanisms mediating initial adsorption of coagulation proteins to live cells were investigated. Adsorption kinetics were examined under varying flow conditions using tracer-dilution techniques in perfused spherical monolayers of cells expressing tissue factor. At biologically relevant time and concentration ranges, r...

journal_title：Thrombosis and haemostasis

authors： McGee MP,Teuschler H

更新日期：1999-07-01 00:00:00

abstract：:We have established a new analytical method which allows the characterization of von Willebrand factor (vWF) degradation fragments in minute amounts (10 microliters) of plasma, without the need for immunopurification of vWF. Plasma vWF was hydrolysed by S aureus V-8 protease (V-8 protease) and the cleaved fragments se...

journal_title：Thrombosis and haemostasis

authors： Takahashi Y,Kalafatis M,Girma JP,Meyer D

更新日期：1988-12-22 00:00:00

abstract：:Inherited thrombophilia has been shown to be linked with fetal loss. We performed a case-control study on the association between thrombosis-related polymorphisms in the factor V (FV) gene (Leiden, Cambridge, Hong Kong; HR2 haplotype) and idiopathic recurrent pregnancy loss (RPL) in Tunisian women. A total of 348 wome...

journal_title：Thrombosis and haemostasis

authors： Zammiti W,Mtiraoui N,Mercier E,Abboud N,Saidi S,Mahjoub T,Almawi WY,Gris JC

更新日期：2006-04-01 00:00:00

abstract：:Samples taken at various stages of preparation of intermediate purity factor VIII concentrate were assayed for factor VIII coagulant activity (VIII:C), factor VIII coagulant antigen (VIIIC:Ag) and factor VIII related antigen (VIIIR:Ag). The antigen results were used to assess mechanical loss during fractionation as th...

journal_title：Thrombosis and haemostasis

authors： Prowse CV,Griffin B,Pepper DS,Dickson AJ,McQuillan TA,Dickson IH,Foster PR

更新日期：1981-10-01 00:00:00

abstract：:Angiogenic activity and formation of a vascular network facilitate tumor perfusion and play a critical role in tumor growth and metastasis. Tumor vasculature may be visualized by means of parametric imaging of specific morphological and physiological characteristics that collectively describe its properties. In this r...

journal_title：Thrombosis and haemostasis

authors： Degani H,Chetrit-Dadiani M,Bogin L,Furman-Haran E

更新日期：2003-01-01 00:00:00

abstract：:Glu-plasminogen binds to platelets; the monocytoid line, U937, and the human fetal fibroblast line, GM1380 bind both plasminogen and its activator, urokinase. This study assesses the interaction of these fibrinolytic proteins with circulating human blood cells. Plasminogen bound minimally to red cells but bound satura...

journal_title：Thrombosis and haemostasis

authors： Miles LA,Plow EF

更新日期：1987-10-28 00:00:00

abstract：:Seasonal variation in venous thromboembolism (VTE) risk in individuals with familial predisposition to VTE has not been explored. This nationwide study aimed to determine whether there are age- and sex-specific seasonal differences in risk of hospitalisation of VTE among individuals with and without a family history o...

journal_title：Thrombosis and haemostasis

authors： Zöller B,Li X,Ohlsson H,Sundquist J,Sundquist K

更新日期：2013-12-01 00:00:00

abstract：:Factor Xa (fXa)-inhibitors are as effective and safer than vitamin-K-antagonists (VKA) in the treatment of venous thromboembolism (VTE). We previously classified the severity of clinical presentation and course of all major bleeding events from the EINSTEIN, AMPLIFY and HOKUSAI-VTE trials separately. The current aim w...

journal_title：Thrombosis and haemostasis

authors： Bleker SM,Brekelmans MPA,Eerenberg ES,Cohen AT,Middeldorp S,Raskob G,Büller HR

更新日期：2017-10-01 00:00:00

abstract：:We have previously reported that platelets from bleeding Simmental cattle do not aggregate in vitro in response to ADP, collagen and calcium ionophore A23187, though calcium mobilization and myosin light chain phosphorylation do occur. The aggregation abnormality, measured by aggregometry, was ascribed to abnormal cyt...

journal_title：Thrombosis and haemostasis

authors： Frojmovic MM,Wong T,Searcy GP

更新日期：1996-12-01 00:00:00