Age differences in intercorrelations between regional cerebral metabolic rates for glucose.

Abstract:

:Patterns of cerebral metabolic intercorrelations were compared in the resting state in 15 healthy young men (ages 20 to 32 years) and 15 healthy elderly men (ages 64 to 83 years). Controlling for whole-brain glucose metabolism, partial correlation coefficients were determined between pairs of regional cerebral metabolic rates for glucose determined by positron emission tomography using [18F]fluorodeoxyglucose and obtained in 59 brain regions. Compared with the young men, the elderly men had fewer statistically significant correlations, with the most notable reductions observed between the parietal lobe regions, and between the parietal and frontal lobe regions. These results suggest that cerebral functional interactions are reduced in healthy elderly men.

journal_name

Ann Neurol

journal_title

Annals of neurology

authors

Horwitz B,Duara R,Rapoport SI

doi

10.1002/ana.410190111

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

60-7

issue

1

eissn

0364-5134

issn

1531-8249

journal_volume

19

pub_type

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