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Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.

Abstract：

:We propose that a fundamental problem in the faithful replication of complex chromosomes of higher eukaryotes is the proper control of both the number and timing of the multiple initiations of replication on single chromosomes. When replication patterns are disrupted by any of a variety of agents, overreplication of DNA can occur. We propose a model that accounts for the generation of a wide variety of chromosomal aberrations-rearrangements, resulting from the various ways in which the overreplicated strands can undergo recombination. We also discuss certain implications of the generation of chromosomal alterations in higher eukaryotes as they may relate to cancer chemotherapy, cancer progression, aging, and rapid speciation-evolution.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Schimke RT,Sherwood SW,Hill AB,Johnston RN

doi

10.1073/pnas.83.7.2157

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

2157-61

issue

7

eissn

0027-8424

issn

1091-6490

journal_volume

83

pub_type

杂志文章

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