High dose versus low dose dexamethasone in experimental epidural spinal cord compression.

Abstract:

:A compound of methylcellulose-silicone expanding progressively over a 1-week period by moisture absorption was implanted in the midthoracic epidural space of 17 Sprague Dawley adult rats. When the animals became paraplegic 6.3 +/- 1.6 days later, they were randomized into three groups: untreated control (n = 5), high dose dexamethasone (HD, 1.25 mg/kg intramuscularly, twice daily, n = 5), and low dose dexamethasone (LD, 0.125 mg/kg intramuscularly, twice daily, n = 7). Motor strength was evaluated daily by an observer unaware of the treatment given to the rats. Animals treated with dexamethasone (HD or LD) improved faster than untreated control animals. No significant difference in the rate of recovery or degree of motor improvement was noted between the HD and LD groups. Mortality was higher in the HD group because of infections and gastrointestinal perforation/bleeding.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Delattre JY,Arbit E,Rosenblum MK,Thaler HT,Lau N,Galicich JH,Posner JB

doi

10.1227/00006123-198806010-00005

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

1005-7

issue

6 Pt 1

eissn

0148-396X

issn

1524-4040

journal_volume

22

pub_type

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  • A New Classification for Pathologies of Spinal Meninges-Part 2: Primary and Secondary Intradural Arachnoid Cysts.

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    更新日期:2008-01-01 00:00:00

  • Cerebral arterial revascularization: the value of repeated angiography in selection of patients for operation.

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