Abstract：
Background/Aims:Integrated relaxation pressure (IRP) is defined as the average minimum esophagogastric junction (EGJ) pressure for 4 seconds of relaxation (contiguous or noncontiguous) within 10 seconds of swallowing. The durability of IRP values during successive swallows in the supine position remains to be elucidated. The aim is to determine alteration in IRP values during successive swallows among subjects with normal esophageal manometry versus those with esophagogastric junction outflow obstruction (EGJOO). Methods:Consecutive subjects, who underwent high-resolution esophageal manometry (HREM) were included in the study. Individuals had to have either normal manometry or EGJOO. A total of 10 wet swallows of 5 mL water were performed after an adaptation period of a minimum of 3 minutes. Mean IRP were analyzed for both subject groups for each individual swallow. Results:Thirty-one patients with EGJOO and seventy patients with normal manometry were included. As expected, the median IRP was higher in EGJOO patients compared to those with normal HREM (mean: 23.92 vs 5.34, P < 0.001). The mean IRP of the last swallow was 40% lower than the mean IRP of the first swallow in the normal subjects (P = 0.015). In contrast, the difference in the mean IRP value in the EGJOO group between the first and the last swallow was 19% (P = 0.018). Conclusions:This study demonstrated that there is a significant decline in the mean IRP during successive swallows in subjects with normal esophageal manometry and those with EGJOO, despite adequate adaptation periods. This decline in IRP was less pronounced in EGJOO.
journal_name
J Neurogastroenterol Motiljournal_title
Journal of neurogastroenterology and motilityauthors
Elangovan A,Shibli F,Fass Rdoi
10.5056/jnm20139subject
Has Abstractpub_date
2021-01-28 00:00:00eissn
2093-0879issn
2093-0887pii
jnm20139pub_type
杂志文章abstract：:Visceral pain is the most common form of pain caused by varied diseases and a major reason for patients to seek medical consultation. It also leads to a significant economic burden due to workdays lost and reduced productivity. Further, long-term use of non-specific medications is also associated with side effects aff...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm15026
更新日期：2015-03-30 00:00:00
abstract：BACKGROUND/AIMS:To evaluate the effects of the phosphodiesterase type 5 (PDE5) inhibitor vardenafil on esophageal function, including bolus transit, using multichannel intraluminal impedance and esophageal manometry (MII-EM). METHODS:Sixteen healthy volunteers (15 men) underwent an MII-EM study including 10 liquid swa...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm.2012.18.4.399
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND/AIMS:Interstitial cells of Cajal (ICC) play important functions in motor activity of the gastrointestinal tract. The role of ICC as pace-makers is well established, however their participation in neurotransmission is controversial. Studies using mutant animals that lack ICC have yielded variable conclusions ...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm.2014.20.2.171
更新日期：2014-04-30 00:00:00
abstract：:Author's name was mis-typed. The name "Oya B Sezer" in the original article should have been written as "Oya Balcı Sezer." ...
journal_title：Journal of neurogastroenterology and motility
pub_type： 已发布勘误
doi：10.5056/jnm25012
更新日期：2019-01-31 00:00:00
abstract：BACKGROUND/AIMS:Solifenacin, a muscarinic type 3 receptor antagonist, is used to treat overactive bladder in adults. The aim of this study is to examine the efficacy of solifenacin on the symptomatic relief of diarrhea predominant irritable bowel syndrome (IBS-D). METHODS:A total of 20 patients with IBS-D were enrolle...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm.2012.18.3.317
更新日期：2012-07-01 00:00:00
abstract：Background/Aims:Functional dyspepsia (FD) is characterized as chronic recurrent upper gastrointestinal symptoms in the absence of any organic disorder. We hypothesized that duodenal low-grade inflammation activates superficial afferent nerve sprouting, thereby contributing to hypersensitivity in patients with FD. Meth...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm18176
更新日期：2019-04-30 00:00:00
abstract：:In predisposed individuals with long standing gastroesophageal reflux disease (GERD), esophageal squamous mucosa can transform into columnar mucosa with intestinal metaplasia, commonly called Barrett's esophagus (BE). Barrett's mucosa can develop dysplasia, which can be a precursor for esophageal adenocarcinoma (EAC)....
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm18156
更新日期：2019-04-30 00:00:00
abstract：Background/Aims:Currently, there exists no biomarker for visceral hypersensitivity in irritable bowel syndrome (IBS). Piezo proteins have been proven to play an important role in the mechanical stimulation to induce visceral pain in other tissues and may also be a biomarker candidate. The aim of this study was to test ...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm16114
更新日期：2017-07-30 00:00:00
abstract：BACKGROUND/AIMS:Gastrointestinal symptoms and hypothalamus-pituitary-adrenal (HPA) axis dysfunction are frequently observed in patients with major depression. The primary aim of the study was to investigate the relationship between HPA-axis function and self-perceived functional gastrointestinal symptoms in major depre...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm15064
更新日期：2016-04-30 00:00:00
abstract：:Constipation in children is a common health problem affecting 0.7% to 29.6% children across the world. Exact etiology for developing symptoms is not clear in children and the majority is considered to have functional constipation. Alteration of rectal and pelvic floor function through the brain-gut axis seems to play ...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm.2011.17.1.35
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND/AIMS:Gastroparesis-like syndrome (GLS) is defined as gastroparesis-like symptoms with normal gastric scintigraphy. While the efficacy of gastric electrical stimulation (GES) in gastroparesis is well known, the utility of GES in GLS is largely unknown. Our aim was to clarify the role of GES in GLS. We implant...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm15046
更新日期：2015-10-01 00:00:00
abstract：:An increase in intracellular Ca(2+) is the primary trigger of contraction of gastrointestinal (GI) smooth muscles. However, increasing the Ca(2+) sensitivity of the myofilaments by elevating myosin light chain phosphorylation also plays an essential role. Inhibiting myosin light chain phosphatase activity with protein...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章,评审
doi：10.5056/jnm15186
更新日期：2016-04-30 00:00:00
abstract：Background/Aims:Current evidence suggests the presence of motility or functional abnormalities in one area of the gastrointestinal tract increases the likelihood of abnormalities in others. However, the relationship of gastroparesis to chronic constipation (slow transit constipation and dyssynergic defecation) has been...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm18206
更新日期：2019-04-30 00:00:00
abstract：Background/Aims:Interstitial cells play important roles in gastrointestinal (GI) neuro-smooth muscle transmission. The underlying mechanisms of colonic dysmotility have not been well illustrated. We established a partial colon obstruction (PCO) mouse model to investigate the changes of interstitial cells and the correl...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm19136
更新日期：2019-10-30 00:00:00
abstract：BACKGROUND/AIMS:Approximately one-third of non-erosive reflux disease (NERD) patients are refractory to proton pump inhibitors (PPI) and face a therapeutic challenge. Therefore, it is important to differentiate between pathological and non-pathological reflux utilizing multichannel intraluminal impedance-pH (MII-pH) to...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm14038
更新日期：2014-10-30 00:00:00
abstract：BACKGROUND/AIMS:The marketing of newer agents for treatment of constipation and irritable bowel syndrome with constipation (IBS-C) emphasize improvements in abdominal pain. However, it is not clear whether this observation reflects a unique visceral analgesic effect of these agents or is a general feature of effective ...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm15171
更新日期：2016-01-31 00:00:00
abstract：BACKGROUND/AIMS:Several motility disorders are associated with disruption of interstitial cells of Cajal (ICC), which provide important functions, such as pacemaker activity, mediation of neural inputs and responses to stretch in the gastrointestinal (GI) tract. Restoration of ICC networks may be therapeutic for GI mot...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm14026
更新日期：2014-07-31 00:00:00
abstract：Background/Aims:Irritable bowel syndrome (IBS) is a common disease characterized by intestinal dysmotility, the mechanism of which remains elusive. We aim to determine whether the high-affinity choline transporter 1 (CHT1), a determinant of cholinergic signaling capacity, modulates intestinal motility associated with s...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm18040
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND/AIMS:Irritable bowel syndrome (IBS) is one of the most frequently observed disorders by primary care and practitioners. The aim of this study was to estimate the prevalence of IBS using the Rome II and III criteria in the general Korean population and also to compare sociodemographic differences between subj...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm.2010.16.2.186
更新日期：2010-04-01 00:00:00
abstract：Background/Aims:The prevalence and severity of irritable bowel syndrome (IBS) declines with age, but the cause of this is unknown. This study tested 2 hypotheses: (1) autonomic nervous system responses to eating and bowel distention, measured by heart rate variability (HRV), differs by age in IBS patients and (2) HRV i...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm16216
更新日期：2018-01-30 00:00:00
abstract：:Live imaging has become an essential tool to investigate the coordinated activity and output of cellular networks. Within the last decade, 2 Nobel prizes have been awarded to recognize innovations in the field of imaging: one for the discovery, use, and optimization of the green fluorescent protein (2008) and the seco...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm15096
更新日期：2015-07-30 00:00:00
abstract：Background/Aims:Probiotics are expected to modify the composition of gut microbiota. We aimed to investigate the changes in the composition and diversity of gut microbiota by the administration of probiotics in healthy individuals. Methods:Twelve healthy volunteers with age range of 30-42 years provided baseline fecal...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm17140
更新日期：2018-07-30 00:00:00
abstract：:Irritable bowel syndrome (IBS) has been one of the commonly presented gastrointestinal disorders. It is of interest how commonly it presents in the society. Western studies indicated that most population-based IBS prevalences range 10%-15%. It is believed that IBS is prevalent in both East and West countries without a...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm.2010.16.4.389
更新日期：2010-10-01 00:00:00
abstract：Background/Aims:The Gastroesophageal Reflux Disease Questionnaire (GerdQ) has been developed and validated as a tool for the diagnosis of gastroesophageal reflux disease (GERD) in patients with gastrointestinal symptoms. However, the GerdQ and the cutoff value for determining GERD has not been validated in Korea. Meth...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm18133
更新日期：2019-01-31 00:00:00
abstract：:Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophagea...
journal_title：Journal of neurogastroenterology and motility
pub_type： 评审
doi：10.5056/jnm19081
更新日期：2019-10-30 00:00:00
abstract：BACKGROUND/AIMS:Rome criteria classifying functional gastrointestinal disorder (FGID) were updated. The aims of this study were to assess the spectra of FGID and to evaluate the applicability of Rome III criteria in Korea. METHODS:New patients who visited 2 primary clinics and 2 tertiary care hospitals were consecutiv...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm.2011.17.3.279
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND/AIMS:To draw a normative database of laryngopharynx pH profile in Chinese subjects. METHODS:Normal volunteers were recruited from "www.Ganji.com" and People's hospital between May 2008 and December 2009. The Restech pH Probes were calibrated in pH 7 and pH 4 buffer solutions according to the manufacturer's ...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm13138
更新日期：2014-07-31 00:00:00
abstract：Background/Aims:Lipopolysaccharide (LPS) is the key factor inducing mucosal and systemic inflammation in various intestinal and parenteral diseases, which could initially disrupt the epithelial barrier function. EphrinA1/ephA2 is speculated to increase the epithelial permeability for its "repulsive interaction" between...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm19095
更新日期：2020-07-30 00:00:00
abstract：:Assessment of transit through the gastrointestinal tract provides useful information regarding gut physiology and patho-physiology. Although several methods are available, each has distinct advantages and limitations. Recently, an ingestible wire-less motility capsule (WMC), similar to capsule video endoscopy, has bec...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm.2014.20.2.265
更新日期：2014-04-30 00:00:00
abstract：Background/Aims:The prevalence of eosinophilic esophagitis (EoE) is reportedly increasing in Western countries. However, its prevalence in Korea remains unknown. We investigated the diagnostic trends and clinical characteristics of EoE in Korea. Methods:Using an endoscopic database maintained at a tertiary care center...
journal_title：Journal of neurogastroenterology and motility
pub_type： 杂志文章
doi：10.5056/jnm17047
更新日期：2018-04-30 00:00:00
