Large granular lymphocyte leukaemia study at the University Hospital of Donostia.

Abstract:

INTRODUCTION:Large granular lymphocyte (LGL) leukaemia is considered a mature T-cell or natural killer (NK) cell neoplasm, characterised by a clonal proliferation of LGL. AIMS:To analyse the characteristics and to establish (if possible) the prognostic parameters of these patients diagnosed in a single centre: University Hospital of Donostia. METHODS:We retrospectively studied data about 308 patients with LGL leukaemia diagnosed in our centre. RESULTS:The frequency of T-LGL leukaemia and chronic lymphoproliferative disorder of NK cells was 89% and 6.8% respectively, and no aggressive NK-LGL leukaemia was seen in our population. The median age at diagnosis was 65.7 years and male-to-female ratio was 1.08. 59% of our patients were asymptomatic at the time of diagnosis. Most patients presented lymphocytosis and 63.6% more than 20% LGLs in the peripheral blood count, but it has to be taken into account that these results may be influenced by the selection bias of our study, as we recognised these patients as 'alarms of the laboratory analysers'. Neutropenia was the most common cytopenia, and autoimmune disorders were described in 16.5% of the patients. Only 12 patients (3.9%) required treatment, a much lower percentage that the one reported in the literature, and this is consistent with the fact that patients were less symptomatic than in other series, as we expected. The 5-year and 15-year overall survival was 92% and 87%, respectively. CONCLUSIONS:Our patients may represent the even more benign end of the spectrum of clonal T LGL and NK proliferations.

journal_name

J Clin Pathol

authors

Uranga A,González C,Furundarena JR,Robado N,Rey M,Aragon L,Urreta I,Aranbarri A,De Juan MD,Araiz M

doi

10.1136/jclinpath-2020-207191

subject

Has Abstract

pub_date

2021-01-21 00:00:00

eissn

0021-9746

issn

1472-4146

pii

jclinpath-2020-207191

pub_type

杂志文章
  • Mast cells in the human alveolar wall: an electronmicroscopic study.

    abstract::Mast cells were identified by electronmicroscopy in the alveolar wall of the lung in 20 subjects (10 normal, 10 abnormal). A quantitative and qualitative study was made of the mast cells. In the normal lung there was an average concentration of 350 mast cells/mm2 of alveolar wall and in the abnormal 523/mm2. Mast cell...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.34.12.1333

    authors: Fox B,Bull TB,Guz A

    更新日期:1981-12-01 00:00:00

  • Latex agglutination for rapid detection of Pseudomonas pseudomallei antigen in urine of patients with melioidosis.

    abstract::A latex agglutination test for the detection of Pseudomonas pseudomallei antigen in urine was evaluated for the rapid diagnosis of melioidosis. With unconcentrated urine, antigen was detected in only 18% of patients with melioidosis overall. However, when urine was concentrated 100-fold, antigen was detected in 47% ov...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.48.2.174

    authors: Smith MD,Wuthiekanun V,Walsh AL,Teerawattanasook N,Desakorn V,Suputtamongkol Y,Pitt TL,White NJ

    更新日期:1995-02-01 00:00:00

  • Congenital mesoblastic nephroma: possible prognostic and management value of assessing DNA content.

    abstract::The case records and pathology of all children with kidney tumours treated in the West Midlands Health Authority Region (WMHAR) from 1957 to 1986 were reviewed. The histology was reviewed by a panel of three paediatric pathologists. Thirteen (6%) out of 211 cases were considered to have congenital mesoblastic nephroma...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.44.4.317

    authors: Barrantes JC,Toyn C,Muir KR,Parkes SE,Raafat F,Cameron AH,Marsden HB,Mann JR

    更新日期:1991-04-01 00:00:00

  • Scedosporium apiospermum in chronic granulomatous disease treated with an HLA matched bone marrow transplant.

    abstract::A patient with chronic granulomatous disease who was being treated with steroids was diagnosed with a soft tissue Scedosporium apiospermum infection. Despite extensive treatment with antifungals progression to involve solid tissue (bone) occurred. Treatment required an HLA matched bone marrow transplant, which led to ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.55.10.784

    authors: Gompels MM,Bethune CA,Jackson G,Spickett GP

    更新日期:2002-10-01 00:00:00

  • Hypercalcaemia due to hyperparathyroidism in a patient with chronic renal failure and renal carcinoma.

    abstract::A 65-year-old woman with a history of a left heminephrectomy for renal carcinoma developed hypercalcaemia 11 years after the operation. The same kidney was found to contain a recurrent renal carcinoma. After the radical nephrectomy of the left kidney, hypercalcaemia remitted but reappeared 11 months later. The right k...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.32.3.234

    authors: Szwed JJ,Gott LJ,Lempke RE,Seo IS

    更新日期:1979-03-01 00:00:00

  • Gross examination and reporting of soft tissue tumours: evaluation of compliance with the UK Royal College of Pathologists soft tissue sarcoma dataset.

    abstract:AIMS:Soft tissue tumours are a heterogeneous group of neoplasms that can arise at almost every anatomical site. As they often show similar clinical and radiological findings, histology is the definitive diagnostic method and it is crucial that the surgical pathology report contains accurate, useful information for mana...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2015-203495

    authors: Shah C,Wang J,Mubako T,Fisher C,Thway K

    更新日期:2016-09-01 00:00:00

  • Hepatitis B antigen (HBAg) and its antibody (HBAb) in hospital patients.

    abstract::Sera from 5171 inpatients have been tested for HBAg and HBAb during the 18-month period ending in December 1972. The incidence of HBAg (0.116%) was similar to that in blood donors (0.119%) in the same area, being tested for the first time by the same technique. By contrast the incidence of HBAb in patients (0.271%) wa...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.27.2.125

    authors: Payne RW,Barr A,Wallace J

    更新日期:1974-02-01 00:00:00

  • Evaluation of API 20 STREP system for identifying Listeria species.

    abstract::The API 20 STREP system was used to identify 146 known strains from seven species of the genus Listeria, including both pathogenic and environmental strains. The gallery was easy to use and tests, with the exception of leucine arylamidase (LAP) and starch fermentation (AMD), were simple to interpret. Identification to...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.42.5.548

    authors: MacGowan AP,Marshall RJ,Reeves DS

    更新日期:1989-05-01 00:00:00

  • Overexpression of Pim-1 during progression of prostatic adenocarcinoma.

    abstract:AIMS:Pim-1 is a serine/threonine kinase that has been shown to play an integral role in the development of a number of human cancers, such as haematolymphoid malignancies. Recently, evidence has shown Pim-1 to be important in prostatic carcinogenesis. In order to further our understanding of its role in prostate cancer...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2005.027672

    authors: Cibull TL,Jones TD,Li L,Eble JN,Ann Baldridge L,Malott SR,Luo Y,Cheng L

    更新日期:2006-03-01 00:00:00

  • A comparison of rapid methods including imprint cytodiagnosis for the diagnosis of breast tumours.

    abstract::Rapid diagnoses were made on 510 breast lumps by three methods in sequence and the results compared with those obtained by paraffin histology.Naked-eye examination of the excised lumps correctly distinguished between benign and malignant tumours in 95.1% of cases with 23 (4.5%) false negative and two (0.4%) false posi...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.26.4.273

    authors: Tribe CR

    更新日期:1973-04-01 00:00:00

  • Haematological features of primary myelodysplastic syndromes (PMDS) at initial presentation: a study of 118 cases.

    abstract::The haematological features of 118 cases of primary myelodysplastic syndromes (PMDS) were reviewed to see how these could be related and classified according to the recent FAB proposals. A majority of the cases were elderly who presented with a macrocytic or normocytic anaemia and reticulocytopenia. Cases of acquired ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.36.10.1129

    authors: Juneja SK,Imbert M,Jouault H,Scoazec JY,Sigaux F,Sultan C

    更新日期:1983-10-01 00:00:00

  • Endometrial pathology in postmenopausal tamoxifen treatment: comparison between gynaecologically symptomatic and asymptomatic breast cancer patients.

    abstract:AIMS:To evaluate whether endometrial pathology is more likely to be diagnosed in gynaecologically symptomatic rather than in gynaecologically asymptomatic postmenopausal breast cancer patients with tamoxifen treatment; and to evaluate the possible influence of various clinical factors on the incidence of endometrial pa...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.52.4.278

    authors: Cohen I,Perel E,Flex D,Tepper R,Altaras MM,Cordoba M,Beyth Y

    更新日期:1999-04-01 00:00:00

  • Comparison of three methods for culture confirmation of Neisseria gonorrhoeae strains currently circulating in the UK.

    abstract:AIMS:To establish the current sensitivity of two commercial kits for culture confirmation of Neisseria gonorrhoeae strains circulating in the UK. METHODS:A total of 544 strains were studied (199 gonococci from male patients attending hospitals in the county of Avon, 204 unselected N gonorrhoeae isolates from male pati...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.48.10.919

    authors: Turner A,Gough KR,Jephcott AE

    更新日期:1995-10-01 00:00:00

  • Gas-liquid chromatography in the diagnosis of anaerobic infections: a three year experience.

    abstract::Nearly two thousand clinical samples were examined by direct gas-liquid chromatography over a three year period. Absence of volatile fatty acids (VFAs) in the samples correlated well with negative culture results for anaerobic bacteria. In general the presence of acetic acid alone correlated well with the presence of ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.35.7.709

    authors: Watt B,Geddes PA,Greenan OA,Napier SK,Mitchell A

    更新日期:1982-07-01 00:00:00

  • Lipoprotein (a) and stroke.

    abstract::Strokes are one of the most common causes of mortality and long term severe disability. There is evidence that lipoprotein (a) (Lp(a)) is a predictor of many forms of vascular disease, including premature coronary artery disease. Several studies have also evaluated the association between Lp(a) and ischaemic (thrombot...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jcp.53.7.487

    authors: Milionis HJ,Winder AF,Mikhailidis DP

    更新日期:2000-07-01 00:00:00

  • Cyclin dependent kinase inhibitor p27Kip1 expression in normal and neoplastic cervical epithelium.

    abstract:AIM:To investigate whether there is loss of the p27Kip1 protein in developing cervical cancer and whether p27Kip1 immunoreactivity has any relation to the proliferative indicator Ki-67. METHODS:The expression of p27Kip1 and Ki-67 was assessed by immunohistochemistry in serial sections from normal epithelium (13), low ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.52.12.880

    authors: Troncone G,Vetrani A,de Rosa G,Gerbasio D,Palombini L

    更新日期:1999-12-01 00:00:00

  • Fatal renal failure as the first manifestation of sarcoidosis diagnosed on necropsy in a young man: a case report.

    abstract::Renal involvement as the first manifestation of sarcoidosis is rare and has never been reported in India. This report describes a 35 year old man who was admitted to the emergency department with a clinical diagnosis of acute on chronic renal failure, secondary to obstructive uropathy. Postmortem examination unexpecte...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jcp.2004.018325

    authors: Awasthi A,Nada R,Malhotra P,Goel R,Joshi K

    更新日期:2004-10-01 00:00:00

  • Reversible absorptive defects in anticonvulsant megaloblastic anaemia.

    abstract::Two cases of anticonvulsant megaloblastic anaemia are described, showing features of unusual interest. Though both cases were apparently deficient in folic acid, the Figlu tests were negative. One patient had an extremely low serum B(12) concentration apparently associated with defective B(12) absorption due to defici...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.18.5.593

    authors: Reynolds EH,Hallpike JF,Phillips BM,Matthews DM

    更新日期:1965-09-01 00:00:00

  • Production of freeze-dried human antihaemophilic cryoprecipitate.

    abstract::Concentration of factor VIII from fresh plasma by cryoprecipitation remains the basis for preparation of products used to treat haemophilia A. This paper describes the preparation of a factor VIII concentrate from small plasma pools in transfusion centres with drying facilities. The dried concentrate from one litre of...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.34.10.1091

    authors: Millgan G,Graham R,Hanratty S,Muir W,Mitchell R

    更新日期:1981-10-01 00:00:00

  • Dose response relationships and interference of simultaneous skin tests in delayed hypersensitivity.

    abstract::The relationship between the intensity of the delayed hypersensitivity reaction and the dose of antigen used for its elicitation change with time after sensitization. At three weeks the reactions to 100 mug of egg albumen were little different from those to 1 mug but at 14 weeks 100 mug gave much stronger reactions. T...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.26.9.687

    authors: Jokipii AM,Jokipii L

    更新日期:1973-09-01 00:00:00

  • Potential role of IgG avidity for diagnosing toxoplasmosis.

    abstract::Sera from 20 cases of toxoplasmic lymphadenopathy were examined by an enzyme linked immunosorbent assay toxoplasma IgG avidity (ELISA) at two laboratories. The results obtained were largely in agreement and showed that sera from patients with acute infection had low avidity IgG (30% or less), whereas sera from patient...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.43.12.1032

    authors: Joynson DH,Payne RA,Rawal BK

    更新日期:1990-12-01 00:00:00

  • Cost effectiveness of routine postmortem histology.

    abstract::In a retrospective study of the records of 160 necropsies it was found that, according to the clinical and gross necropsy findings, no clinically important abnormality would have been anticipated in 46% of the tissue samples. The estimated annual cost of processing this material alone was pounds 10,500, including the ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.40.4.459

    authors: Reid WA

    更新日期:1987-04-01 00:00:00

  • Use of orcein in detecting hepatitis B antigen in paraffin sections of liver.

    abstract::This study has shown that different supplies/batches of orcein perform differently and may fail. The "natural" forms generally performed better although the most informative results were obtained with a "synthetic" product. Orcein dye solutions can be used soon after preparation and for up to 7 days without the need f...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.35.4.430

    authors: Kirkpatrick P

    更新日期:1982-04-01 00:00:00

  • A histochemical comparison of the O-acylated sialic acids of the epithelial mucins in ulcerative colitis, Crohn's disease, and normal controls.

    abstract::Two histochemical techniques, the PAT/KOH/PAS and the PBT/KOH/PAS, were used to investigate the side chain O-acyl substitution patterns of the sialic acids of the colonic epithelial mucins in cases of ulcerative colitis and Crohn's disease. In both diseases there was, as compared to normal, a reduction in the proporti...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.32.12.1272

    authors: Culling CF,Reid PE,Dunn WL

    更新日期:1979-12-01 00:00:00

  • Use of the 'Analmatic clinical system' in the microbiological assay of vitamin B 12 and folic acid in serum.

    abstract::The routine estimation of large numbers of serum folic acid and vitamin B(12) levels using the Baird and Tatlock(1) Analmatic clinical system is described and the method evaluated.Precision, accuracy, and carryover are shown to be at acceptable levels, and the advantages and disadvantages of the use of the system are ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.24.1.18

    authors: Colvin G,Gibson GL,Neill DW

    更新日期:1971-02-01 00:00:00

  • Normal osteoid tissue.

    abstract::The results of a histological study of normal osteoid tissue in man, the monkey, the dog, and the rat, using thin microtome sections of plastic-embedded undecalcified bone, are described. Osteoid tissue covers the entire bone surface, except for areas of active resorption, although the thickness of the layer of osteoi...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.25.3.229

    authors: Raina V

    更新日期:1972-03-01 00:00:00

  • Idiopathic acquired sideroblastic anaemia transforming to acute myelosclerosis.

    abstract::A case of idiopathic acquired sideroblastic anaemia transforming to acute myelofibrosis is reported. The appearance of atypical megakaryocytic proliferation in idiopathic acquired sideroblastic anaemia may presage the development of an acute myelofibrotic phase of this usually chronic disease. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.37.9.1032

    authors: Bested AC,Cheng G,Pinkerton PH,Kassim O,Senn JS

    更新日期:1984-09-01 00:00:00

  • Variants of Escherichia coli giving the appearance of mixed growths in urine.

    abstract::Urines from patients with symptoms of urinary tract infection yielded mixed growths of different colony types of Escherichia coli. The different colony types were found to be variants of single infecting strains caused by mutation or by phase action. It is suggested that care should be exercised in the interpretation ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.28.9.728

    authors: Nichols GL

    更新日期:1975-09-01 00:00:00

  • Observer variability in histopathological reporting of cervical biopsy specimens.

    abstract::Sections from 100 cervical biopsy specimens were studied by 12 consultant histopathologists to determine the robustness of the existing pathology terminology and classification. Analysis by kappa statistics showed good agreement in the diagnosis of CIN 3 and squamous carcinoma but an inability to distinguish accuratel...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.42.3.231

    authors: Robertson AJ,Anderson JM,Beck JS,Burnett RA,Howatson SR,Lee FD,Lessells AM,McLaren KM,Moss SM,Simpson JG

    更新日期:1989-03-01 00:00:00

  • The effect of delay in fixation on HER2 expression in invasive carcinoma of the breast assessed with immunohistochemistry and in situ hybridisation.

    abstract:AIMS:Accurate assessment of HER2 status is essential for selection of patients for HER2-targeted treatment such as trastuzumab. This study investigated the hypothesis that delayed fixation impairs HER2 assessment. METHODS:9 carcinomas were received fresh, and samples were fixed immediately or put in fixative at time i...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2013-201978

    authors: Lee AH,Key HP,Bell JA,Kumah P,Hodi Z,Ellis IO

    更新日期:2014-07-01 00:00:00