Abstract:
:Ribonucleotides are the most abundant non-canonical nucleotides in the genome. Their vast presence and influence over genome biology is becoming increasingly appreciated. Here we review the recent progress made in understanding their genomic presence, incorporation characteristics and usefulness as biomarkers for polymerase enzymology. We also discuss ribonucleotide processing, the genetic consequences of unrepaired ribonucleotides in DNA and evidence supporting the significance of their transient presence in the nuclear genome.
journal_name
Crit Rev Biochem Mol Bioljournal_title
Critical reviews in biochemistry and molecular biologyauthors
Zhou ZX,Williams JS,Lujan SA,Kunkel TAdoi
10.1080/10409238.2020.1869175subject
Has Abstractpub_date
2021-02-01 00:00:00pages
109-124issue
1eissn
1040-9238issn
1549-7798journal_volume
56pub_type
杂志文章abstract::Glycosaminoglycans (GAGs) play an intricate role in the extracellular matrix (ECM), not only as soluble components and polyelectrolytes, but also by specific interactions with growth factors and other transient components of the ECM. Modifications of GAG chains, such as isomerization, sulfation, and acetylation, gener...
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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journal_title:Critical reviews in biochemistry and molecular biology
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