Abstract:
:Recently, a small-molecule communication mechanism was discovered in a range of Bacillus-infecting bacteriophages, which these temperate phages use to inform their lysis-lysogeny decision. We present a mathematical model of the ecological and evolutionary dynamics of such viral communication, and show that a communication strategy in which phages use the lytic cycle early in an outbreak (when susceptible host cells are abundant) but switch to the lysogenic cycle later (when susceptible cells become scarce) is favoured over a bet-hedging strategy in which cells are lysogenised with constant probability. However, such phage communication can evolve only if phage-bacteria populations are regularly perturbed away from their equilibrium state, so that acute outbreaks of phage infections in pools of susceptible cells continue to occur. Our model then predicts the selection of phages that switch infection strategy when half of the available susceptible cells have been infected.
journal_name
Elifejournal_title
eLifeauthors
Doekes HM,Mulder GA,Hermsen Rdoi
10.7554/eLife.58410subject
Has Abstractpub_date
2021-01-18 00:00:00issn
2050-084Xpii
58410journal_volume
10pub_type
杂志文章相关文献
eLife文献大全abstract::TOR complex 1 (TORC1) is an evolutionarily conserved protein kinase complex that promotes cellular macromolecular synthesis and suppresses autophagy. Amino-acid-induced activation of mammalian TORC1 is initiated by its recruitment to the RagA/B-RagC/D GTPase heterodimer, which is anchored to lysosomal membranes throug...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30880
更新日期:2017-12-04 00:00:00
abstract::Numerous brain regions have been shown to have neural correlates of gradually accumulating evidence for decision-making, but the causal roles of these regions in decisions driven by accumulation of evidence have yet to be determined. Here, in rats performing an auditory evidence accumulation task, we inactivated the f...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.05457
更新日期:2015-04-14 00:00:00
abstract::The number of ions required to drive substrate transport through a secondary active transporter determines the protein's ability to create a substrate gradient, a feature essential to its physiological function, and places fundamental constraints on the transporter's mechanism. Stoichiometry is known for a wide array ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.21016
更新日期:2017-01-25 00:00:00
abstract::Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue patterns during development. Here, we report endocytic sorting signals for the receptor Patched1 (Ptch1), comprising two 'PPXY' motifs, that direct it to degra...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.02555
更新日期:2014-06-12 00:00:00
abstract::Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulators down regulate this exaggerated proinflammatory response following L...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.54556
更新日期:2020-03-02 00:00:00
abstract::Neurons coding for head-direction are crucial for spatial navigation. Here we explored the cellular basis of head-direction coding in the rat dorsal presubiculum (PreS). We found that layer2 is composed of two principal cell populations (calbindin-positive and calbindin-negative neurons) which targeted the contralater...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14592
更新日期:2016-06-10 00:00:00
abstract::Recent work draws attention to community-community encounters ('coalescence') as likely an important factor shaping natural ecosystems. This work builds on MacArthur's classic model of competitive coexistence to investigate such community-level competition in a minimal theoretical setting. It is shown that the ability...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.15747
更新日期:2016-06-16 00:00:00
abstract::Previously we identified Lam/GramD1 proteins, a family of endoplasmic reticulum membrane proteins with sterol-binding StARkin domains that are implicated in intracellular sterol homeostasis. Here, we show how these proteins exchange sterol molecules with membranes. An aperture at one end of the StARkin domain enables ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53444
更新日期:2019-12-04 00:00:00
abstract::A broadly known method to stimulate the growth potential of axons is to elevate intracellular levels of cAMP, however the cellular pathway(s) that mediate this are not known. Here we identify the Dual Leucine-zipper Kinase (DLK, Wnd in Drosophila) as a critical target and effector of cAMP in injured axons. DLK/Wnd is ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14048
更新日期:2016-06-07 00:00:00
abstract:: ...
journal_title:eLife
pub_type: 已发布勘误
doi:10.7554/eLife.66683
更新日期:2021-01-25 00:00:00
abstract::Complexin regulates spontaneous and activates Ca(2+)-triggered neurotransmitter release, yet the molecular mechanisms are still unclear. Here we performed single molecule fluorescence resonance energy transfer experiments and uncovered two conformations of complexin-1 bound to the ternary SNARE complex. In the cis con...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.16886
更新日期:2016-06-02 00:00:00
abstract::Goal-directed behavior involves distributed neuronal circuits in the mammalian brain, including diverse regions of neocortex. However, the cellular basis of long-range cortico-cortical signaling during goal-directed behavior is poorly understood. Here, we recorded membrane potential of excitatory layer 2/3 pyramidal n...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.15798
更新日期:2016-06-21 00:00:00
abstract::The spliceosome is a complex machine composed of small nuclear ribonucleoproteins (snRNPs) and accessory proteins that excises introns from pre-mRNAs. After assembly the spliceosome is activated for catalysis by rearrangement of subunits to form an active site. How this rearrangement is coordinated is not well-underst...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.14166
更新日期:2016-05-31 00:00:00
abstract::SUMO-modification of nuclear proteins has profound effects on gene expression. However, non-toxic chemical tools that modulate sumoylation in cells are lacking. Here, to identify small molecule sumoylation inhibitors we developed a cell-based screen that focused on the well-sumoylated substrate, human Liver Receptor H...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.09003
更新日期:2015-12-11 00:00:00
abstract::The CRISPR-Cas9 bacterial surveillance system has become a versatile tool for genome editing and gene regulation in eukaryotic cells, yet how CRISPR-Cas9 contends with the barriers presented by eukaryotic chromatin is poorly understood. Here we investigate how the smallest unit of chromatin, a nucleosome, constrains t...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.13450
更新日期:2016-04-28 00:00:00
abstract::Actin filaments assemble inside the nucleus in response to multiple cellular perturbations, including heat shock, protein misfolding, integrin engagement, and serum stimulation. We find that DNA damage also generates nuclear actin filaments-detectable by phalloidin and live-cell actin probes-with three characteristic ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.07735
更新日期:2015-08-19 00:00:00
abstract::Pattern completion, or the ability to retrieve stable neural activity patterns from noisy or partial cues, is a fundamental feature of memory. Theoretical studies indicate that recurrently connected auto-associative or discrete attractor networks can perform this process. Although pattern completion and attractor dyna...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.53125
更新日期:2020-07-14 00:00:00
abstract::Purkinje neurons are central to cerebellar function and show membrane bistability when recorded in vitro or in vivo under anesthesia. The existence of bistability in vivo in awake animals is disputed. Here, by recording intracellularly from Purkinje neurons in unanesthetized larval zebrafish (Danio rerio), we unequivo...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.09158
更新日期:2015-09-29 00:00:00
abstract::Macrophage activation/polarization to distinct functional states is critically supported by metabolic shifts. How polarizing signals coordinate metabolic and functional reprogramming, and the potential implications for control of macrophage activation, remains poorly understood. Here we show that IL-4 signaling co-opt...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.11612
更新日期:2016-02-19 00:00:00
abstract::Multi-modal MRI techniques have identified biomarkers that could help to predict whether someone will develop epilepsy. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.29853
更新日期:2017-07-26 00:00:00
abstract::We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture pas...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.58042
更新日期:2020-08-24 00:00:00
abstract::Gap junctions are widely distributed in the brains across species and play essential roles in neural information processing. However, the role of gap junctions in insect cognition remains poorly understood. Using a flight simulator paradigm and genetic tools, we found that gap junctions are present in Drosophila Kenyo...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.13238
更新日期:2016-05-24 00:00:00
abstract::Microtubules are nucleated from specific locations at precise times in the cell cycle. However, the factors that constitute these microtubule nucleation pathways and their mode of action still need to be identified. Using purified Xenopus laevis proteins we biochemically reconstitute branching microtubule nucleation, ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.49797
更新日期:2020-01-14 00:00:00
abstract::Mitochondria play important roles in cellular processes and disease, yet little is known about how the transcriptional regime of the mitochondrial genome varies across individuals and tissues. By analyzing >11,000 RNA-sequencing libraries across 36 tissue/cell types, we find considerable variation in mitochondrial-enc...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.41927
更新日期:2019-02-18 00:00:00
abstract::The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury. Here, we report novel pathways in axon regeneration, identified by extending our previous function-based screen using the C. elegans...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39756
更新日期:2018-11-21 00:00:00
abstract::New data on the relationship between two proteins, cyclin D and Rb, suggest that we need to re-evaluate our understanding of how cells enter into the cell cycle. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.03475
更新日期:2014-07-01 00:00:00
abstract::The biological players involved in angiogenesis are only partially defined. Here, we report that endothelial cells (ECs) express a novel isoform of the cell-surface adhesion molecule L1CAM, termed L1-ΔTM. The splicing factor NOVA2, which binds directly to L1CAM pre-mRNA, is necessary and sufficient for the skipping of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.44305
更新日期:2019-03-04 00:00:00
abstract::Islet amyloidosis by IAPP contributes to pancreatic β-cell death in diabetes, but the nature of toxic IAPP species remains elusive. Using concurrent time-resolved biophysical and biological measurements, we define the toxic species produced during IAPP amyloid formation and link their properties to induction of rat IN...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.12977
更新日期:2016-05-23 00:00:00
abstract::Dendrites shape information flow in neurons. Yet, there is little consensus on the level of spatial complexity at which they operate. Through carefully chosen parameter fits, solvable in the least-squares sense, we obtain accurate reduced compartmental models at any level of complexity. We show that (back-propagating)...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.60936
更新日期:2021-01-26 00:00:00
abstract::Recurrent somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate K27M or G34R/V mutant histone H3.3. H3.3-G34R/V mutants are common in tumors with mutations in p53 and ATRX, an H3.3-specific chromatin remodeler. To gain insight into the role of H3-G34R, we generated fission yeast that express o...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.27406
更新日期:2017-07-18 00:00:00