Abstract:
OBJECTIVES:The dysbiotic oral microbiome plays a key role in the pathogenesis of caries in children. Topical application of casein phosphopeptide-amorphous calcium phosphate containing fluoride (CPP-ACP/F) is an effective treatment modality for children with caries (CC). Hitherto the mechanism by which CPP-ACP/F modules the oral microbiome in CC has not been investigated. The study aimed to examine the CPP-ACP/F effect on the dental plaque microbiome of children group with caries. METHODS:This preliminary prospective clinical cohort included 10 children with caries. The children received topical fluoride CPP-ACP/F once-a-week for one month. Plaque samples were collected before and after treatment and subjected to 16S rDNA-based next-generation-sequencing. Microbial composition, diversity and functional roles were analyzed in comparison to the clinical characteristics of cohort using standard bioinformatics tools. RESULTS:CPP-ACP/F treatment modulated dysbiotic oral microbiome towards healthier community as the higher proportion of Proteobacteria and certain microbial protective species were enriched following CPP-ACP/F treatment. Despite overall uniformity of community structure in children with caries between the groups, some bacterial species were differentially represented in a statistically significant manner between pre- and post- treatments. Three bacterial species were found to be predictive of strongly sensitive to the CPP-ACP/F treatment, marked by decreased abundance of Lautropia mirabalis and increased abundance of Gemella haemolysans and Schwartzia succinivorans. CONCLUSION:Within the limits of the current study, it could be concluded that the CPP-ACP/F varnish treatment modulated the microbial composition of the dental plaque microbiome towards symbiosis. These symbiotic changes may demonstrate the potential clinical significance of CPP-ACP/F varnish treatment.
journal_name
J Dentjournal_title
Journal of dentistryauthors
Widyarman AS,Udawatte NS,Theodorea CF,Apriani A,Richi M,Astoeti TE,Seneviratne CJdoi
10.1016/j.jdent.2021.103582subject
Has Abstractpub_date
2021-01-12 00:00:00pages
103582eissn
0300-5712issn
1879-176Xpii
S0300-5712(21)00003-8journal_volume
106pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-04-01 00:00:00
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更新日期:2013-09-01 00:00:00
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更新日期:2010-02-01 00:00:00
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更新日期:2002-01-01 00:00:00
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更新日期:2018-02-01 00:00:00
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更新日期:2015-12-01 00:00:00
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更新日期:2004-03-01 00:00:00