Abstract：
OBJECTIVES:Intrahepatic cholestasis in pregnancy (ICP) is a pregnancy-specific liver disorder. Its etiology is not fully understood. Increasing evidence indicates the important role of vitamin D and the vitamin D receptor (VDR) in this disorder. The presence of polymorphic variants in the VDR gene could influence its activity and susceptibility to ICP development. The goal of the study was to investigate the role of four genetic polymorphisms of the VDR gene - Fok (rs731236), Bsm (rs1544410), Apa (rs7975232), and Taq (rs731236) - in the etiology of ICP in Polish women. MATERIAL AND METHODS:Ninety-eight women with confirmed ICP and 215 healthy pregnant women as a control group were recruited to the study. We examined four SNPs of the VDR gene: BsmI (rs7975232), TaqI (rs1544410), ApaI (rs228570), FokI (rs731236). Genotyping was performed using the PCR/RFLP method. RESULTS:We observed higher frequency (borderline significant) of the Ff-ff genotypes containing at least one mutated allele of the VDR FokI polymorphism in the control group compared to the ICP group (p = 0.045, OR = 1.71, 95% CI 1.01-2.88). The frequency of the mutated f allele was slightly higher in controls (49.1%) than in the ICP group (43.4%) (OR = 1.26, 95% CI 0.90-1.77), but the difference was not statistically significant (p = 0.196). CONCLUSIONS:Our results showed that the maternal VDR FokI polymorphism could play a protective role in ICP development and probably modulate the risk of ICP occurrence in pregnant women in the Polish population. In the future, to confirm these observations, research in larger, ethnically stratified and clinically analyzed groups is necessary.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Wolski H,Kurzawinska G,Ozarowski M,Drews K,Barlik M,Piatek K,Malewski Z,Mrozikiewicz AE,Magielda-Stola J,Kolanowska D,Wolek M,Seremak-Mrozikiewicz Adoi
10.5603/GP.a2020.0135subject
Has Abstractpub_date
2020-01-01 00:00:00pages
719-725issue
12eissn
0017-0011issn
2543-6767pii
VM/OJS/J/69051journal_volume
91pub_type
杂志文章abstract：:Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. It is manifested by hyperandrogenism, polycystic ovaries on ultrasound, oligomenorrhoea and anovulation. PCOS patients are more vulnerable to metabolic disorders: insulin resistance, obesity endothelium dysfunction, athero...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2015-04-01 00:00:00
abstract：UNLABELLED:The aim of the study was to evaluate antioxidant system activity and lipid peroxidations products as markers of oxidative stress in the cord blood of newborns delivered to mothers with diabetes type G1 in comparison to healthy pregnant women. MATERIALS AND METHODS:We examined 10 healthy and 10 diabetic moth...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:182 hysteroscopic operations with electroresectoscope use performed in Ist Department of Obstetrics and Gynaecology (Warsaw) between 1996-1999 were analyzed. Myomectomy was performed in 117 patients, resection of uterine septum in 25 and deliberation of intrauterine adhesions in 40 patients. Abnormal bleeding and infe...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Selected clinical features of the course of pregnancy in 118 gravidas with placenta praevia diagnosed ultrasonographically on the first breeding were compared. The clinical features significantly connected with bleeding and the prognostic features for the way of delivery were stated. The longest bleeding was observed ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVES:Congenital heart diseases are very serious problem of current perinatology. Early detection of congenital heart diseases and new possibilities of their treatment have decreased mortality rate in neonates. THE AIM OF THE STUDY:Was to present the reasons of the heart murmurs found in newborns, based on postna...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:The aim of the paper was to evaluate the anatomical state of uterine adnexa in women operated on due to mechanical infertility. Hydrotubation were previously applied in 31 women stemming from various centres in the country, while in 31 such a treatment was not performed at all. The mentioned groups of women were encum...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Among 64 women undergoing tubal-ovarian surgery 40.6% became pregnant spontaneously. Because of 47% of the remainder patients demonstrated anovulation the induction of ovulation was performed except the cases with hypergonadotrophic hypogonadism (9.4%). After treatment the total population with ovulatory cycles increa...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:The paper contains the description of the modification of simplified method for caesarean section, based on the Joel-Cohen and Misgav Ladach method. Advantages of the simplified methods are described on the basis of the cited papers. Following stages of procedure are described in details. ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：INTRODUCTION:Endometriosis is defined as the appearance of ectopic endometrial cells outside the uterine cavity. Ectopic cells demonstrate functional similarity to eutopic cells, but structural and molecular differences are significant and manifest themselves in gene expression of the metalloproteinase genes, integrin ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/1751
更新日期：2014-06-01 00:00:00
abstract：UNLABELLED:The aim of the study was to analyze life-threatening conditions of the premature neonates who required hospitalization in The Neonatal Intensive Care Unit (NICU). Postnatal mortality was also taken into consideration. MATERIAL AND METHODS:The study group consisted of the neonates born prematurely in the Obs...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-10-01 00:00:00
abstract：OBJECTIVES:Surgical site infection (SSI) following gynecologic oncology surgery is a severe problem for both patient and surgeon in terms of increasing morbidity, length of hospital stay, anxiety, and costs. In this prospective, randomized, controlled study we investigated the effect of subcutaneous rifampicin and povi...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2020.0134
更新日期：2020-01-01 00:00:00
abstract：:The efficiency of glycemia control was compared in two groups of insulin dependent diabetic pregnancies treated with insulin, with and without the aid of the Camit-Diacomp system. The efficiency of glycemia control was analysed in all three trimesters of pregnancy. Mean diurnal fluctuations of glycemia levels in both ...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:Water is a substance essential for life. It creates the environment of our body, keeps it's homeostasis, enables every biochemical reaction and metabolic processes in human organism. Maternal hydratation is essential for homeostasis of two organisms and drinking water influences the amniotic fluid volume, fetal well-b...
journal_title：Ginekologia polska
pub_type： 指南,杂志文章,实务指引
doi：
更新日期：2009-07-01 00:00:00
abstract：:Between 1994-1999 at the Department for Diagnosis of Congenital Malformations at the PPMH Institute there were ultrasound and echocardiography examinations performed in 40 fetuses with Down Syndrome. In our study most of the cases come from low risk groups of pregnant women. Congenital heart defects (AV-canal in 13/18...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Oral anticoagulants are contraindicated during pregnancy, especially during the I and III trimester, therefore heparin is recommended instead. We used fraxiparine s.c. once daily in prophylactic doses in 6 patients during pregnancy and labor (mean time of prophylaxis 6.5 months). Two of them received fraxiparine becau...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1996-11-01 00:00:00
abstract：OBJECTIVES:The indications for hysterectomy after caesarean section, postoperative period, and pathological examination of women. In whom hysterectomy hampered operated delivery, are being hereby analysed. MATERIALS AND METHODS:The study group consisted of 15 patients who gave birth in I Clinic Medical Academy in Wars...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-06-01 00:00:00
abstract：OBJECTIVES:The goal of this study was to evaluate the frequency of Sp1 +1245G>T (rs 1800012) and -199 7G>T (rs 1107946) COL1A1 gene polymorphisms in postmenopausal women with osteoporosis and osteopenia as well as assessing their relations with the clinical parameters and parameters of bone turnover. STUDY DESIGN:The ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.17772/gp/60550
更新日期：2015-12-01 00:00:00
abstract：:According to the European Dialysis and Transplantation Association at least 250 patients on each 1 million of inhabitants in Europe is treated with renal replacement therapy. One can assumed that if only half of above mentioned are women then from 5 to 10 of them can conceive pregnant. It's likely that number of pregn...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：1995-07-01 00:00:00
abstract：OBJECTIVES:Evaluation of testicular tissue is very important diagnostic procedures in cryptozoospermia and azoospermia. It is verified the patient for treatment (stimulation spermatogenesis), for micromanipulation ICSI or for insemination donor semen procedure. Surgical biopsy is very popular between andrologist and ur...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:A monochorionic monoamniotic (MCMA) twin pregnancy is the rarest form of twin gestation, accounting for around 1:10000 to 1:20000 of all deliveries regardless of the region of the world. All multiple gestations have a higher risk of preterm delivery due to either preterm uterine contractions or asymptomatic cervical s...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2012-12-01 00:00:00
abstract：:The influence of hormone replacement therapy (HRT) on coagulation system has not been completely explained yet. We measured plasma activities of antithrombin III, protein C and protein S before and after 6 and 12 months of HRT in 48 postmenopausal women. HRT consisted of transdermal estradiol and orally medroxyprogest...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：:This study was performed in 52 women in their early postmenopausal period, divided into two equal groups. The control group included women with menopausal symptoms only, women in the study group demonstrated also pruritus. All women were on estrogen replacement therapy, additionally a bacterial auto-vaccine was admini...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Women have three very important physiological functions that are not observed in men--menstruation, pregnancy and lactation. Each of these mechanisms influences pharmacokinetics and pharmacodynamics of many drugs. Individualization of pharmacotherapy is a major challenge of modern medicine. The differences in response...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/2002
更新日期：2015-02-01 00:00:00
abstract：:Treatment of the malignant ovarian tumors remains challenging. Some of the reasons are as follows: lack of effective screening technique, usually asymptomatic early stages of the disease, which effects in detecting the disease in advanced stage, and eventually poor prognosis. Treatment of the relapse remains palliativ...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/59268
更新日期：2016-01-01 00:00:00
abstract：AIM:To evaluate the a-chemokine stromal cell-derived factor-1 (SDF-1)/CXCL12 levels in the peritoneal fluid (PF) and plasma of patients with epithelial ovarian cancer (EOC, n=101), serous cyst (n=34) or normal controls (n=20). SDF-1alpha concentrations were correlated to myeloid (M) and lymphoid (L) dendritic cells (DC...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：:Thrombotic thrombocytopenic purpura (TTP) is characterized by microangiopathic hemolytic anemia and thrombocytopenia, accompanied by microvascular thrombosis that causes variable degrees of tissue ischemia and infarction. About 10-20% of TTP cases are associated with the pregnancy. Preterm delivery and intrauterine fe...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2008-07-01 00:00:00
abstract：OBJECTIVES:To assess the effectiveness of the donor-block biopsies with a 2 mm-size needle in endometrioid endometrial cancer (EEC) in the tissue microarray (TMA) technique and the application of the TMA for estrogen receptors (ER) and progesterone receptors (PR) expression in EEC. MATERIAL AND METHODS:The study exami...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVES:This study was conducted in order to produce translation, cultural adaptation, and validation of Assessment of Pelvic Floor Disorders and Their Risk Factors During Pregnancy and Postpartum Questionnaire (APFDQ) to Turkish in pregnant and postpartum population. MATERIAL AND METHODS:The study included 80 preg...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2020.0072
更新日期：2020-01-01 00:00:00
abstract：:Basic methods of contraception of unwanted pregnancy are reviewed: mechanical, vaginal devices, hormonal tablets, and IUDs. On the basis of personal experience the author considers that, compared with other methods of contraception, the intrauterine spiral is the safest device for the female organism. An evaluation...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1975-03-01 00:00:00
abstract：OBJECTIVES:The aim of our study is to determine whether first-trimester neutrophil-to-lymphocyte ratio (NLR) and plate-let-to-lymphocyte ratio (PLR) would be useful as new predictors of subsequent preeclampsia. MATERIAL AND METHODS:Medical records of women with preeclampsia and healthy controls from a tertiary referra...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2016.0021
更新日期：2016-01-01 00:00:00
