Abstract：
:Networks linking single genes to multiple phenotypic outcomes can be founded on local anatomical interactions as well as on systemic factors like biochemical products. Here we explore the effects of such interactions by investigating the competing spatial demands of brain and masticatory muscle growth within the hypermuscular myostatin-deficient mouse model and in computational simulations. Mice that lacked both copies of the myostatin gene (-/-) and display gross hypermuscularity, and control mice that had both copies of the myostatin gene (+/+) were sampled at 1, 7, 14 and 28 postnatal days. A total of 48 mice were imaged with standard as well as contrast-enhanced microCT. Size metrics and landmark configurations were collected from the image data and were analysed alongside in silico models of tissue expansion. Findings revealed that: masseter muscle volume was smaller in -/- mice at day 1 but became, and remained thereafter, larger by 7 days; -/- endocranial volumes begin and remained smaller; -/- enlargement of the masticatory muscles was associated with caudolateral displacement of the calvarium, lateral displacement of the zygomatic arches, and slight dorsal deflection of the face and basicranium. Simulations revealed basicranial retroflexion (flattening) and dorsal deflection of the face associated with muscle expansion and abrogative covariations of basicranial flexion and ventral facial deflection associated with endocranial expansion. Our findings support the spatial-packing theory and highlight the importance of understanding the harmony of competing spatial demands that can shape and maintain mammalian skull architecture during ontogeny.
journal_name
J Anatjournal_title
Journal of anatomyauthors
Jeffery NS,Sarver DC,Mendias CLdoi
10.1111/joa.13393subject
Has Abstractpub_date
2021-01-13 00:00:00eissn
0021-8782issn
1469-7580pub_type
杂志文章abstract：:It is known that removal of one eye in the rat in early postnatal life results in an aberrant ipsilateral projection from the remaining eye. We have estimated the number of optic nerve fibres in 36 days old Black and White Hooded rats that had been unilaterally enucleated at birth. There was no significant difference ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1991-02-01 00:00:00
abstract：:The meaning of the term 'abdomen' has become increasingly ambiguous, as it has to satisfy the contemporary requirements of natural language discourse, literature, gross and radiological anatomy and its role in ontologies supporting electronic records and data modelling. It is critical that there is an agreed understan...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.13384
更新日期：2021-01-08 00:00:00
abstract：:Hair growth in adult mammals involves continuous dermal-epidermal interaction across the follicular basement membrane, and repeated reorganisation of lower follicle structure during the hair growth cycle. The immunolocalisation of 3 extracellular matrix components, fibronectin, laminin and type IV collagen was investi...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1992-08-01 00:00:00
abstract：:Classic anatomical methods have failed to determine the precise location, origin and nature of nerve fibres in the inferior hypogastric plexus (IHP). The purpose of this study was to identify the location and nature (adrenergic and/or cholinergic) of IHP nerve fibres and to provide a three-dimensional (3D) representat...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2009.01071.x
更新日期：2009-05-01 00:00:00
abstract：:The anisotropic, inhomogeneous, multiply collagenous architecture of the annulus reflects the complex pattern of mainly tensile stresses developed in this region of the disc during normal function. Structural and mechanical responses of fully hydrated in-plane sections taken from within single lamellae of the outer an...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/j.1469-7580.2005.00467.x
更新日期：2005-10-01 00:00:00
abstract：:We report a magnetic resonance imaging study which developed a consistent hierarchy of imaging planes for examination of the origins, courses and principal branches of the main coronary arteries of prepared human cadaveric hearts. The reference longitudinal axis was chosen between the aortic valve and the apex of the ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:It is currently thought that New World monkeys, prosimians, and humans are the only primates to possess vomeronasal organs (VNOs) as adults. Recent studies of the human VNO suggest that previous investigations on Old World primates may have missed the VNO. We examined nasal septa from the chimpanzee (Pan troglodytes) ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2001.19810077.x
更新日期：2001-01-01 00:00:00
abstract：:The descending projections to coccygeal spinal segments influencing tail movement were studied by retrograde wheat germ agglutinin-horseradish peroxidase (WGA-HRP) tracing methods in 12 cats. WGA-HRP solution was injected into the 3rd and 4th coccygeal segments and hemisection of the right side of the spinal cord was ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:Previous work, almost four decades ago, showed that hydrocortisone (HC) treatment reduces the number of skeletogenic condensations that give rise to the scleral ossicles in the chicken eye. The scleral ossicles are a ring of overlapping intramembranous bones, the sclerotic ring, and are present in most reptiles, inclu...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12744
更新日期：2018-02-01 00:00:00
abstract：:A quantitative comparison of the internal diameters of cerebral feeder arteries (internal carotid and vertebral) and the aorta in developing non-human eutherians, metatherians and monotremes has been made, with the aim of determining if there are differences in cerebral arterial flow between the three infraclasses of ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12422
更新日期：2016-03-01 00:00:00
abstract：:The articular facets of the sustentaculum tali have a variety of configurations that are generally viewed as nonmetric traits of little functional significance. Bruckner (1987), in contrast, has hypothesised that sustentaculum tali facet variations are functionally important because they influence subtalar joint stabi...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:The morphological features of odontoblast processes in young kitten odontoblasts were studied by thin section and freeze-fracture electron microscopy. Freeze-fracture replication revealed depressions with particles on the plasma membranes of the proximal parts of odontoblast processes. Comparison with thin sections su...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
abstract：:The arteries of the skin have been postulated to form a profound plexus at the dermal/hypodermal junction and a superficial plexus in the papillary dermis. Our article aims to rebut this concept and to provide an alternative description of the arrangement of the dermal arteries. Employing a novel technique, we produce...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12113
更新日期：2013-12-01 00:00:00
abstract：:Age at death estimation of human skeletal remains is one of the key issues in constructing a biological profile both in forensic and archaeological contexts. The traditional adult osteological methods evaluate macroscopically the morphological changes that occur with increasing age of specific skeletal indicators, suc...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/joa.12544
更新日期：2019-08-01 00:00:00
abstract：:The study aim was to explore the anatomy, histopathology, and molecular biological function of the fascias posterior to the interperitoneal colon and its mesocolon to provide information for improving complete mesocolic excision. To accomplish this aim, we performed intraoperative observations in 60 interperitoneal co...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12066
更新日期：2013-08-01 00:00:00
abstract：:In the spinotrapezius muscle of the rat and the mouse approximately equal proportions of A,B and C fibres are present. The spinotrapezius therefore contains a lower proportion of B fibres than are known to be present in soleus, but a higher proportion than in tibialis anterior. These results are consistent with the fu...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-02-01 00:00:00
abstract：:The pituitary of roach, Rutilus rutilus (L.), is pear-shaped and situated in the sella turcica. It is characterised by a large pars nervosa, which penetrates deep into the other regions, splitting the proximal pars distalis. Spatial localisation of nerve fibre types and glandular cell types occurs. Using a variety of ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
abstract：:The ultrastructure of the basal lamina of histologically normal human breast tissue was determined in 19 women undergoing operations for removal of a fibroadenoma or reduction mammoplasty. The day of the menstrual cycle was determined by hormone assay and direct questioning. Previously documented ultrastructural appea...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1988-02-01 00:00:00
abstract：:The vestibular system, located in the inner ear, plays a crucial role in balance and gaze stabilisation by sensing head movements. The interconnected tubes with membranous walls of the vestibular system are located in the skull bone (the 'membranous labyrinth'). Unfortunately, these membranes are very hard to visualis...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12885
更新日期：2018-12-01 00:00:00
abstract：:The heart is the first functioning organ to develop during embryogenesis. The formation of the heart is a tightly regulated and complex process, and alterations to its development can result in congenital heart defects. Mutations in sarcomeric proteins, such as alpha myosin heavy chain and cardiac alpha actin, have no...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12486
更新日期：2016-09-01 00:00:00
abstract：:The lumbar muscular system, in particular the lumbar multifidus muscle (LM) and the erector spinae muscle (ES), plays an important role in stabilizing and mobilizing the lumbar spine. Based on the topography, the lumbar paraspinal muscles can be classified into local and global muscles. LM is part of the local system,...
journal_title：Journal of anatomy
pub_type： 临床试验,杂志文章
doi：10.1111/joa.12867
更新日期：2018-10-01 00:00:00
abstract：:Genetic mutation leads to anatomical variation only indirectly because many proteins involved in generating anatomical structures in embryos operate cooperatively within molecular networks. These include gene-regulatory or control networks (CNs) for timing, signaling and patterning together with the process networks (...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12205
更新日期：2014-08-01 00:00:00
abstract：:Amoeboid microglial cells (AMC) in the corpus callosum were selectively labelled following a single intraperitoneal (i.p.) injection of the fluorescent dye, rhodamine isothiocyanate (RhIc) into postnatal rats. The frequency of RhIc-labelled cells varied with age, with the largest number occurring in 7-d-old animals. T...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1993-02-01 00:00:00
abstract：:The fine structure of the elastic cartilage of the pinna has been examined in young rabbits aged from 1 day to 1108 days. Changes associated with growth and development are related not only to age but also to the actual situation in the pinna. In the midline, progressive changes are seen from the tip to the base. The ...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1977-04-01 00:00:00
abstract：:The process by which the pronephros develops was morphologically examined in chick embryos from Hamburger-Hamilton stage (ST) 8+ to ST34. The intermediate mesoderm, from which the pronephros arises, was first seen as a faint ridge of undifferentiated mesoderm between the segmental plate and lateral plate at ST8+. It f...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1046/j.1469-7580.2003.00245.x
更新日期：2003-12-01 00:00:00
abstract：:The mammalian cochlea is a remarkable sensory organ, capable of perceiving sound over a range of 10(12) in pressure, and discriminating both infrasonic and ultrasonic frequencies in different species. The sensory hair cells of the mammalian cochlea are exquisitely sensitive, responding to atomic-level deflections at s...
journal_title：Journal of anatomy
pub_type： 杂志文章,评审
doi：10.1111/joa.12314
更新日期：2016-02-01 00:00:00
abstract：:The formation of a placenta is critical for successful mammalian pregnancy and requires remodelling of the uterine epithelium. In eutherian mammals, remodelling involves specific morphological changes that often correlate with the mode of embryonic attachment. Given the differences between marsupial and eutherian plac...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：10.1111/joa.12610
更新日期：2017-07-01 00:00:00
abstract：:Epiphyses of man and dog in various stages of union are described. As union approaches, new cartilage is added to the epiphyseal surface of the cartilaginous epiphyseal plate by chondrification of the epiphyseal marrow. Before and during early union the cellular arrangement of the cartilaginous epiphyseal plate is wel...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
abstract：:Small clusters of extra large muscle fibres were identified in hindlimb muscles of neonatal mice (strain C57BL/10ScSn). At two days of age they had a significantly greater cross-sectional area than their normal counterparts (P less than 0.01). Fibre typing methods (NADH-tetrazolium reductase, ATPase and phosphorylase)...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:The horizontal and vertical diameters of the pedicles of the lumbar vertebrae were measured from plain anteroposterior radiographs of the lumbar spines of male and female subjects aged from 10 to 65 y. The results showed that there were significant differences between the pedicle diameters of males and females. Horizo...
journal_title：Journal of anatomy
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
