Abstract：
:The structural and mechanical properties of tissue and the interplay between them play a critical role in tissue function. We introduce the optomechanogram, a combined quantitative and qualitative visualization of spatially co-registered measurements of the microstructural and micromechanical properties of any tissue. Our approach relies on the co-registration of two independent platforms, second-harmonic generation (SHG) microscopy for quantitative assessment of 3D collagen-fiber microstructural organization, and nanoindentation (NI) for local micromechanical properties. We experimentally validate our method by applying to uterine cervix tissue, which exhibits structural and mechanical complexity. We find statistically significant agreement between the micromechanical and microstructural data, and confirm that the distinct tissue regions are distinguishable using either the SHG or NI measurements. Our method could potentially be used for research in pregnancy maintenance, mechanobiological studies of tissues and their constitutive modeling and more generally for the optomechanical metrology of materials.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee W,Ostadi Moghaddam A,Shen S,Phillips H,McFarlin BL,Wagoner Johnson AJ,Toussaint KC Jrdoi
10.1038/s41598-020-79602-6subject
Has Abstractpub_date
2021-01-11 00:00:00pages
324issue
1issn
2045-2322pii
10.1038/s41598-020-79602-6journal_volume
11pub_type
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