Effect of a serum lactate monitoring recommendation policy on patients treated with linezolid.

Abstract:

ABSTRACT:Lactic acidosis is one of the most fatal adverse effects of linezolid, an antibiotic used to treat serious infections caused by antibiotic-resistant bacteria. However, the measures to prevent lactic acidosis have not been well established.We performed a retrospective study to analyze the impact of applying a serum lactate monitoring recommendation policy in patients treated with linezolid.Since September 2011, we have recommended inpatient monitoring of serum lactate levels in patients treated with linezolid at our hospital. Patients were divided into two groups according to whether they were seen during the non-recommendation or recommendation periods. The frequency of serum lactate monitoring, linezolid-induced lactatemia, lactic acidosis, critical illness, and death were compared between the two periods.After September 2011, adherence to the recommendation to monitor serum lactate increased from 6.1% to 60.1%. No difference was observed in the incidence of linezolid-induced lactatemia and lactic acidosis between the two periods. However, there was a significant difference in the incidence of linezolid-induced critical illness between the non-recommendation and recommendation periods (3 vs 0 cases, P = .044).In patients treated with linezolid, serum lactate monitoring led to early detection of lactatemia, thus enabling rapid rescue. We recommend regular monitoring of serum lactate in all patients treated with linezolid.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Im JH,Lee JS,Chung MH,Kwon HY,Lee MJ,Baek JH

doi

10.1097/MD.0000000000023790

subject

Has Abstract

pub_date

2021-01-08 00:00:00

pages

e23790

issue

1

eissn

0025-7974

issn

1536-5964

pii

00005792-202101080-00016

journal_volume

100

pub_type

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