Vitamin E protects against cadmium-induced sub-chronic liver injury associated with the inhibition of oxidative stress and activation of Nrf2 pathway.

Abstract:

:Hepatic oxidative stress, as one important mechanism of cadmium (Cd)-induced hepatic toxicity, could, as known, be ameliorated by vitamin E (VE). However, the underlying mechanism remains to be elucidated. To investigate whether the antioxidant vitamin E can protect against Cd-induced sub-chronic liver injury associated with oxidative stress and nuclear factor erythrocyte 2-related factor 2 (Nrf2) pathway, male Sprague-Dawley rats (nine-week-old) were randomly divided into four groups (eight rats/group), namely, control, VE (100 mg/kg VE), Cd (5 mg/kg CdCl2) and VE+Cd (100 mg/kg VE+5 mg/kg CdCl2), and received intragastric administration of Cd and/or VE for four weeks. Cd-exposure alone resulted in reduced liver weight, liver histological alteration and oxidative stress, accumulation of Cd in the liver, elevated ALT and AST concentrations in serum together with decreased mRNA and protein expressions of Nrf2 pathway related molecules (Nrf2, HO-1, NQO-1, GCLC, GCLM and GST). However, the co-treatment of Cd and VE significantly ameliorated the changes mentioned above, and promoted the expression of genes and proteins of Nrf2 pathway related molecules in comparison to the Cd-exposure alone. Our results indicate that the protective effect of VE against Cd-induced sub-chronic hepatic damage in rats is associated with the inhibition of oxidative stress and activation of Nrf2 pathway.

journal_name

Ecotoxicol Environ Saf

authors

Fang J,Yin H,Yang Z,Tan M,Wang F,Chen K,Zuo Z,Shu G,Cui H,Ouyang P,Guo H,Chen Z,Huang C,Geng Y,Liu W

doi

10.1016/j.ecoenv.2020.111610

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

111610

eissn

0147-6513

issn

1090-2414

pii

S0147-6513(20)31447-0

journal_volume

208

pub_type

杂志文章
  • Bioaccumulation, sublethal toxicity, and biotransformation of sediment-associated pentachlorophenol in Lumbriculus variegatus (Oligochaeta).

    abstract::The xenobiotics accumulated in sediments represent a hazard to organisms. In order to study the toxic effects of xenobiotics in organisms, body residue has been proposed as a more relevant dose-metric than the environmental concentration of the chemical. In this study, the benthic oligochaetes Lumbriculus variegatus w...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2006.12.019

    authors: Mäenpää K,Sorsa K,Lyytikäinen M,Leppänen MT,Kukkonen JV

    更新日期:2008-01-01 00:00:00

  • Effect of multi-walled carbon nanotubes on extractability of Sb and Cd in contaminated soil.

    abstract::The interaction between multi-walled carbon nanotubes (MWCNTs) and soil heavy metals was rarely studied. With the convenience of detecting multiple metal elements by ICP-AES, this paper examined the potential effectiveness of MWCNTs on extractability of antimony (Sb) and cadmium (Cd) in contaminated soil. Three-step s...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.111316

    authors: Yang Z,Xu Z,Geng L,Shu W,Zhu T

    更新日期:2020-12-01 00:00:00

  • Acute effect of mercury toxicity on some enzymes in liver of teleost Sarotherodon mossambicus.

    abstract::The effects of 1.5 ppm of mercuric chloride (LC50/48 hr) on some enzymes and organic substances of liver tissue of Sarotherodon mossambicus were studied. Significant decreases in the activities of succinate dehydrogenases, lactate dehydrogenases, glucose-6-phosphate dehydrogenase, alkaline phosphatase, and acid phosph...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/0147-6513(84)90024-1

    authors: Naidu KA,Naidu KA,Ramamurthi R

    更新日期:1984-06-01 00:00:00

  • Differential growth and metabolic responses induced by nano-scale zero valent iron in germinating seeds and seedlings of Oryza sativa L. cv. Swarna.

    abstract::Since development of antioxidant defence system is high energy demanding event, innate defence system and stress tolerance of plant is strictly governed by plant age. This study is aimed towards evaluating variation of tolerance in germinating seeds and seedlings of Oryza sativa L. cv. Swarna against nano-scale zero v...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.111104

    authors: Guha T,Gopal G,Chatterjee R,Mukherjee A,Kundu R

    更新日期:2020-11-01 00:00:00

  • Environmental properties of long chain alcohols. Part 1: Physicochemical, environmental fate and acute aquatic toxicity properties.

    abstract::This paper summarises the physicochemical, biodegradation and acute aquatic ecotoxicity properties of long chain aliphatic alcohols. Properties of pure compounds are shown to follow somewhat predictable trends, which are amenable to estimation by quantitative structure-activity relationships ((Q)SARs). This allows pre...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章,评审

    doi:10.1016/j.ecoenv.2008.09.025

    authors: Fisk PR,Wildey RJ,Girling AE,Sanderson H,Belanger SE,Veenstra G,Nielsen A,Kasai Y,Willing A,Dyer SD,Stanton K

    更新日期:2009-05-01 00:00:00

  • Determination of pyraclostrobin dynamic residual distribution in tilapia tissues by UPLC-MS/MS under acute toxicity conditions.

    abstract::As a lipophilic fungicide, pyraclostrobin is highly toxic to aquatic organisms, especially to fish. In recent years, research has mainly focused on the pyraclostrobin residue in fish tissues under chronic toxicity, but less is known about its distribution in fish tissues under acute toxicity conditions. In this study,...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.111182

    authors: Li H,Yang S,Li T,Li X,Huang X,Gao Y,Li B,Lin J,Mu W

    更新日期:2020-12-15 00:00:00

  • Synergism between nickel and copper in their toxicity to microbes: mediation by pH.

    abstract::The toxicity of a combination of nickel (Ni) and copper (Cu) toward growth of heterotrophic microorganisms was greater than the sum of the toxicity of each metal individually. This synergism between Ni and Cu was potentiated at acidic pH levels, with the potentiation of the toxicity being, for some organisms, an effec...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/0147-6513(83)90017-9

    authors: Babich H,Stotzky G

    更新日期:1983-12-01 00:00:00

  • Biological effects of high molecular weight lignin derivatives.

    abstract::A number of high molecular weight (HMW) lignin derivatives possessing varied chemical properties were screened for their biological effects in order to obtain more information on the possible structural features of HMW lignin-related effects. The studied compounds were both commercial and in-house extracted lignin der...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2010.02.004

    authors: Pessala P,Schultz E,Kukkola J,Nakari T,Knuutinen J,Herve S,Paasivirta J

    更新日期:2010-10-01 00:00:00

  • Toxicokinetics and bioaccumulation characteristics of bisphenol analogues in common carp (Cyprinus carpio).

    abstract::Toxicokinetics and bioconcentration of eight common bisphenol analogues, including bisphenol A (BPA), -B, -C, -E, -S, -Z, -AF, and -AP in common carp (Cyprinus carpio) were investigated. Both free (BPfree) and total forms (BPtotal) of the bisphenols were measured in various fish tissues. The conjugated forms of bisphe...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.110183

    authors: Wang Q,Chen M,Qiang L,Wu W,Yang J,Zhu L

    更新日期:2020-03-15 00:00:00

  • Chronic neurodegeneration by aflatoxin B1 depends on alterations of brain enzyme activity and immunoexpression of astrocyte in male rats.

    abstract::Aflatoxin B1 poses the greatest risk among the mycotoxins to target-organisms particularly human, however, no studies addressed the neurotoxicity of chronic exposure of aflatoxin. The oral dose level 1/600th of LD50 for 30, 60, and 90 days was used for three aflatoxin groups, respective to negative and vehicle control...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.109407

    authors: Alsayyah A,ElMazoudy R,Al-Namshan M,Al-Jafary M,Alaqeel N

    更新日期:2019-10-30 00:00:00

  • Quantitative structure-property relationships for direct photolysis of polybrominated diphenyl ethers.

    abstract::Using semiempirical quantum chemical descriptors, by partial least squares (PLS) regression, quantitative structure-property relationships (QSPRs) were established for direct photolysis quantum yields (Phi) and rate constants (k) of polybrominated diphenyl ether congeners dissolved in water/methanol and methanol solut...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2006.01.003

    authors: Chen J,Wang D,Wang S,Qiao X,Huang L

    更新日期:2007-03-01 00:00:00

  • Acute toxicity of locust insecticides to two indigenous invertebrates from Sahelian temporary ponds.

    abstract::During desert locust plagues large amounts of insecticides are used for control operations. Drift from these treatments and accidental overspraying may contaminate small surface waters such as temporary ponds. The present study describes methods for static acute toxicity tests with two abundant organisms that occur in...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.2000.1995

    authors: Lahr J,Badji A,Marquenie S,Schuiling E,Ndour KB,Diallo AO,Everts JW

    更新日期:2001-01-01 00:00:00

  • Uptake and elimination of lindane by Lymnaea palustris (Mollusca: Gastropoda): a pharmacokinetic approach.

    abstract::The uptake and elimination of lindane by adult Lymnaea palustris (Müller) were studied using a static contamination system. First-order one- and two-compartment models were used to quantitatively describe these phenomena. The accumulation of residues was triphasic and the observed steady-state bioconcentration factor ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/0147-6513(91)90075-z

    authors: Thybaud E,Caquet T

    更新日期:1991-06-01 00:00:00

  • Effects of silver nanoparticles on survival, biomass change and avoidance behaviour of the endogeic earthworm Allolobophora chlorotica.

    abstract::Increasing commercial application of silver nanoparticles (Ag NP) and subsequent presence in wastewater and sewage sludge has raised concerns regarding their effects in the aquatic and terrestrial environment. Several studies have employed standardised acute and chronic earthworm-based tests to establish the toxicolog...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2017.03.015

    authors: Brami C,Glover AR,Butt KR,Lowe CN

    更新日期:2017-07-01 00:00:00

  • 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) persistence in the Seveso (Milan, Italy) soil.

    abstract::Preliminary results of a new study on TCDD environmental persistence at Seveso (Milan, Italy) are presented. For this study, the most contaminated territory, Zone A, was divided into areas to fractionate the available TCDD levels in soil into data sets with reduced value spreads. In addition, various time subsets were...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/0147-6513(89)90076-6

    authors: Cerlesi S,Di Domenico A,Ratti S

    更新日期:1989-10-01 00:00:00

  • Genetic damage in coal miners evaluated by buccal micronucleus cytome assay.

    abstract::During coal mining activities, large quantities of coal dust, ashes, polycyclic aromatic hydrocarbons and metals are released into the environment. This complex mixture presents one of the most important occupational hazards for health of workers. The aim of the present study was to evaluate the genetic damage togethe...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2014.05.023

    authors: León-Mejía G,Quintana M,Debastiani R,Dias J,Espitia-Pérez L,Hartmann A,Henriques JA,Da Silva J

    更新日期:2014-09-01 00:00:00

  • Histological changes and copper accumulation in liver and gills of the Senegales sole, Solea senegalensis.

    abstract::Senegales sole, Solea senegalensis, adult specimens were subjected to sublethal copper exposure (100 microg SO(4)Cu/L) for 7 days (contamination period) and afterward kept for 4 days without copper exposure (depuration period). In contaminated and detoxified specimens, the hepatocytes indicated a great number of lipid...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.1999.1801

    authors: Arellano JM,Storch V,Sarasquete C

    更新日期:1999-09-01 00:00:00

  • Antioxidant activity of chemically synthesized AgNPs and biosynthesized Pongamia pinnata leaf extract mediated AgNPs - A comparative study.

    abstract::Biosynthesis of metal nanoparticles is the present research in the limb of nanotechnology which reduces the toxicity of metal nanoparticles. Green chemistry approach emphasizes that the usage of plant material has offered a reliable, simple, nontoxic and eco-friendly that links Nanotechnology and Biotechnology. Increa...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2015.07.037

    authors: Priya RS,Geetha D,Ramesh PS

    更新日期:2016-12-01 00:00:00

  • Metabolite changes behind faster growth and less reproduction of Daphnia similis exposed to low-dose silver nanoparticles.

    abstract::With increasing presence of silver nanoparticles (AgNPs) into the environment, the chronic and low-dose effects of AgNPs are of vital concern. This study evaluated chronic physiological effects of AgNPs on Daphnia similis, which were exposed to two ambient encountered concentrations (0.02 and 1 ppb) of AgNPs for 21 da...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2018.07.080

    authors: Wang P,Ng QX,Zhang H,Zhang B,Ong CN,He Y

    更新日期:2018-11-15 00:00:00

  • Cadmium retention and distribution in contaminated soil: effects and interactions of soil properties, contamination level, aging time and in situ immobilization agents.

    abstract::As soil cadmium (Cd) contamination becomes a serious concern and one of the significant environmental pollution issues all over the world, knowledge of the basic chemistry, origin, inputs, sources, quantity, chemical forms, reactions, as well as the fate and transport of Cd in different types of soil is crucial for be...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.03.001

    authors: Marković J,Jović M,Smičiklas I,Šljivić-Ivanović M,Onjia A,Trivunac K,Popović A

    更新日期:2019-06-15 00:00:00

  • Pb (II) bioavailability to algae (Chlorella pyrenoidosa) in relation to its complexation with humic acids of different molecular weight.

    abstract::Humic acid (HA) has a major influence on the environmental fate of metal ions due to its heterogeneity in chemical compositions, structure and functional groups. In this study, we investigated the effect of humic acid (HA) with different molecular weight (Mw) on the bioavailability of Pb for a representative algae-Chl...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2018.09.114

    authors: Bai H,Wei S,Jiang Z,He M,Ye B,Liu G

    更新日期:2019-01-15 00:00:00

  • Toxic effects of pentachlorophenol and other pollutants on the mineralization of acetate in several soils.

    abstract::The mineralization of [14C]acetate was studied in bottles with fresh soil and groundwater. Addition of toxicants inhibited the formation of 14CO2 and dose-effect curves were obtained. The acetate mineralization was not inhibited by zinc, cadmium, K2Cr2O7, chloropyrifos, and paraquat in an acid sandy soil at 1000 mg/kg...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.1993.1036

    authors: van Beelen P,Fleuren-Kemilä AK

    更新日期:1993-08-01 00:00:00

  • Development of broad spectrum antibodies to heat shock protein 70s as biomarkers for detection of multiple stress by pollutants and environmental factors.

    abstract::To test the hypothesis that broad spectrum antibodies may be developed as biomarkers useful in detecting the consequence of combined environmental stresses in a wide variety of tissues and organisms, a stretch of 16 amino acids, TVPAYFNDSQRQATKDA, a well-conserved portion of heat shock 70 proteins, was identified, aga...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.1997.1544

    authors: Dunlap DY,Matsumura F

    更新日期:1997-08-01 00:00:00

  • Antifouling and toxic properties of the bioactive metabolites from the seagrasses Syringodium isoetifolium and Cymodocea serrulata.

    abstract::The present study documents the antifouling and toxic properties of seagrasses Syringodium isoetifolium and Cymodocea serrulata. For that, the seagrasses S. isoetifolium and C. serrulata were extracted individually using organic solvents viz. dichloromethane, acetone and methanol. Amongst the extracts, the maximum ant...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2014.02.009

    authors: Iyapparaj P,Revathi P,Ramasubburayan R,Prakash S,Palavesam A,Immanuel G,Anantharaman P,Sautreau A,Hellio C

    更新日期:2014-05-01 00:00:00

  • Di(2-ethylhexyl) adipate plasticizer triggers hepatic, brain, and cardiac injury in rats: Mitigating effect of Peganum harmala oil.

    abstract::Di(2-ethylhexyl) adipate (DEHA) is a widely used plasticizer and prevalent environmental contaminant. In this study, DEHA concentrations in the milk, cheese, and butter samples wrapped with food-grade commercial polyethylene films and stored at 4 °C for 30 days were detected using gas chromatographic analysis. Also, t...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.111620

    authors: Behairy A,Abd El-Rahman GI,Aly SSH,Fahmy EM,Abd-Elhakim YM

    更新日期:2021-01-15 00:00:00

  • Biodegradation of phenol by a highly tolerant strain Rhodococcus ruber C1: Biochemical characterization and comparative genome analysis.

    abstract::A novel phenol-degrading strain was isolated and identified as Rhodococcus ruber C1. The degradation analysis shows that 1806 mg/L of phenol can be completely degraded by strain C1 within 38 h, and the maximum specific growth rate (μmax=1.527 h-1) and maximum specific phenol degradation rate (qmax=3.674 h-1) indicate ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2020.111709

    authors: Zhao T,Gao Y,Yu T,Zhang Y,Zhang Z,Zhang L,Zhang L

    更新日期:2021-01-15 00:00:00

  • Calcium availability but not its content modulates metal toxicity in Scenedesmus quadricauda.

    abstract::Impact of calcium nutrition (pre-culture on solid medium with standard or elevated Ca dose, i. e. 0.17 and 4.40mM marked as low and high Ca) on acute metal toxicity (Cd, Mn and Pb, 24h of exposure to 10µM) in freshwater green alga Scenedesmus quadricauda was studied. Surprisingly, Ca content differed only slightly bet...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2017.09.022

    authors: Kováčik J,Dresler S

    更新日期:2018-01-01 00:00:00

  • Cases of mercury exposure, bioavailability, and absorption.

    abstract::Mercury is a unique element that, unlike many metals, has no essential biological function. It is liquid at room temperature and is 13.6 times heavier than water. Its unique physical properties have been exploited for a variety of uses such as in mercury switches, thermostats, thermometers, and other instruments. Its ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章,评审

    doi:10.1016/s0147-6513(03)00060-5

    authors: Gochfeld M

    更新日期:2003-09-01 00:00:00

  • Oral Co-Exposures to zinc oxide nanoparticles and CdCl2 induced maternal-fetal pollutant transfer and embryotoxicity by damaging placental barriers.

    abstract::Synergistic toxicity from multiple environmental pollutants poses greater threat to humans, especially to susceptible pregnant population. Here we evaluated combined toxicity from environment pollutants zinc oxide nanoparticles (ZnO NPs) and cadmium chloride (CdCl2) using two pregnant mice models established by oral a...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1016/j.ecoenv.2019.109956

    authors: Teng C,Jia J,Wang Z,Yan B

    更新日期:2020-02-01 00:00:00

  • Rating systems for pesticide risk classification on different ecosystems.

    abstract::A novel approach is proposed to quantitatively assess the environmental risks associated with the use of plant protection products. Different ranking indexes for the classification of pesticide risk in various environmental systems at different time and space scales have been developed: PRIHS-1 and PRIHS-2 (Pesticide ...

    journal_title:Ecotoxicology and environmental safety

    pub_type: 杂志文章

    doi:10.1006/eesa.2001.2063

    authors: Finizio A,Calliera M,Vighi M

    更新日期:2001-07-01 00:00:00