Abstract：
PURPOSE:Exercise is beneficial to type-2 diabetes-mellitus (T2DM), and there is evidence showing that one of those benefits include a higher expression of brain-derived neurotrophic factor (BDNF), which has been implicated in improving fat oxidation and cognitive development. The deleterious effect of prolonged sedentary time (ST) on BDNF levels has never been examined in patients with T2DM. Our goal was to analyse the associations for sedentary patterns [i.e. breaks in ST per sedentary hour (BST-ST) and bouts of sedentary time (BSB) of different length] with BDNF in patients with T2DM, independent of moderate-to-vigorous physical activity (MVPA) and cardiorespiratory fitness (CRF). METHODS:Sample included 80 patients (38 women) with T2DM (58.3 ± 7.8 years). ST and MVPA were assessed by accelerometry (ActiGraph, GT3X + model), BDNF by blood collection and plasma quantification using commercial enzyme-linked immunosorbent assay kits, and CRF was determined using a Bruce protocol to exhaustion, on a motorized treadmill. RESULTS:Positive associations for BST-ST (β = 0.155; p = 0.007) with BDNF, and negative associations for BSB longer than 15 min with BDNF were found (β = - 0.118; p = 0.049). Neither MVPA nor cardiorespiratory fitness eliminated the associations for BST-ST with BDNF, but MVPA eradicated the associations between BSB > 15 min and BDNF. CONCLUSIONS:Our findings suggest that interrupting ST and especially avoiding longer sedentary periods (> 15 min) may be beneficial for BDNF plasma abundance that may influence metabolic and cognitive functioning of patients with T2DM, especially for the ones presenting lower MVPA levels. TRIAL REGISTRATION:May 5, 2017, ClinicalTrials.govID:NCT03144505.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Júdice PB,Magalhães JP,Hetherington-Rauth M,Correia IR,Sardinha LBdoi
10.1007/s00421-020-04568-2subject
Has Abstractpub_date
2021-01-02 00:00:00eissn
1439-6319issn
1439-6327pii
10.1007/s00421-020-04568-2pub_type
杂志文章abstract：:The purpose of this study was to evaluate the effects of various modes of training on the time-course of changes in lipoprotein-lipid profiles in the blood, cardiovascular fitness, and body composition after 16 weeks of training and 6 weeks of detraining in young women. A group of 48 sedentary but healthy women [mean ...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s004210000234
更新日期：2000-08-01 00:00:00
abstract：PURPOSE:The purpose of this single-blind, repeated measures study was to investigate the effect of two hypoxic patterns, continuous or intermittent on key markers of haematological adaptation, stress and cardiac damage in healthy senior participants. METHODS:Fifteen healthy senior participants each followed a three-ph...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-020-04310-y
更新日期：2020-03-01 00:00:00
abstract：:Sildenafil and epoprostenol are effective therapies in pulmonary arterial hypertension (PAH). Both drugs increase cardiac output, which has been in part attributed to improved right ventricular (RV) contractility. We therefore used tissue Doppler imaging (TDI) to test whether sildenafil and epoprostenol might differen...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-011-2085-y
更新日期：2012-04-01 00:00:00
abstract：:It is a common practice in Northern countries that children aged about 2 weeks to 2 years take their daytime sleep outdoors in prams in winter. The aim was to evaluate the thermal insulation of clothing of infants sleeping outdoors in winter. Clothing data of infants aged 3.5 months was collected, and sleep duration, ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-010-1686-1
更新日期：2011-04-01 00:00:00
abstract：PURPOSE:A previous study observed a joint passive torque increase above baseline ~30 min after a high-intensity stretching. This study examined the effect of a high-intensity stretching on ankle dorsiflexion passive torque, medial gastrocnemius (MG) shear modulus, and plantar flexors maximal voluntary isometric force (...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-016-3410-2
更新日期：2016-08-01 00:00:00
abstract：:While there is some controversy whether anaerobic capacity might be improved after altitude training little is known about changes in anaerobic capacity during hypoxic exposure in highly trained athletes. In order to analyze the effects of acute moderate normobaric hypoxia on anaerobic capacity, 18 male competitive tr...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0473-0
更新日期：2007-09-01 00:00:00
abstract：:Information concerning the validity and reliability of commercial on-line gas analysis systems is limited. The aim of this study was to provide a comparison of the validity and reliability of three on-line systems (Oxycon Alpha, Oxycon Pro and Pulmolab EX670) with that of Douglas bags. Two separate studies were conduc...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-001-0572-2
更新日期：2002-03-01 00:00:00
abstract：:We examined the acute effects of a 1-h strength training session (STS) on plasma amino acid concentration following orally ingestion of leucine, branched-chain amino acids (BCAAs) or glutamine in nine physically active men who participated in double-blinded and randomised experiments. The subjects took placebo, leucin...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0892-6
更新日期：2009-01-01 00:00:00
abstract：:Mechanical loading of cells induces the expression of transforming growth factor-beta-1, and acute exercise, which involves mechanical loading of several tissues, could thus increase its circulating level in humans. However, no consensus exists regarding the plasma concentration of this cytokine in resting subjects (r...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
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更新日期：2003-09-01 00:00:00
abstract：PURPOSE:Acute breath-holding deprives the human body from oxygen. In an effort to protect the brain, the diving response is initiated, coupling several physiological responses. The aim of this study was to describe the physiological responses to apnea at the cardiac, peripheral and cerebral level. METHODS:31 physicall...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-020-04445-y
更新日期：2020-10-01 00:00:00
abstract：PURPOSE:These studies determined (1) age- and sex-related differences in steadiness of isometric contractions when high cognitive demand was imposed across a range of forces with the elbow flexor muscles (study 1) and; (2) sex differences in steadiness among older adults when low cognitive demand was imposed (study 2)....
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-015-3113-0
更新日期：2015-06-01 00:00:00
abstract：:This review discusses brain temperature as a physiological parameter, which is determined primarily by neural metabolism, regulated by cerebral blood flow, and affected by various environmental factors and drugs. First, we consider normal fluctuations in brain temperature that are induced by salient environmental stim...
journal_title：European journal of applied physiology
pub_type： 杂志文章,评审
doi：10.1007/s00421-007-0450-7
更新日期：2007-09-01 00:00:00
abstract：:Isometric maximum voluntary force (MVF) of the adductor pollicis and first dorsal interosseous muscles was measured in 11 pre- and 11 post-menopausal (Pre-M and Post-M) human subjects. The temperature of the hand varied in the range 18°-38°C by water immersion and skin temperature was recorded. MVF at each temperature...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-011-2061-6
更新日期：2012-03-01 00:00:00
abstract：:This study aimed to determine whether brief hypoxic stimuli in a hypobaric chamber are able to elicit erythropoietin (EPO) secretion, and to effectively stimulate erythropoiesis in the short term. In two different experiments, a set of haematological, biochemical, haemorheological, aerobic performance, and medical tes...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210050669
更新日期：2000-06-01 00:00:00
abstract：PURPOSE:Electro-induced (EI) muscle actions are largely used in healthy subjects to improve motor performance, in frail/older subjects to limit sarcopenia and mobility loss, and in pathological subjects to restore functional abilities after injury and/or surgical operation. Their effects on motor output (e.g., muscle s...
journal_title：European journal of applied physiology
pub_type： 杂志文章,评审
doi：10.1007/s00421-020-04383-9
更新日期：2020-07-01 00:00:00
abstract：PURPOSE:Traditional resistance exercise decreases vagal tone up to 30 min after an acute bout of resistance exercise, which may increase the risk of cardiovascular events. However, the effects of resistance exercise with blood flow restriction (BFR) on autonomic modulation are unclear. To evaluate autonomic modulation ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-019-04201-x
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:Females are at greater risks of musculoskeletal injuries than are males, which may be related to decreased neuromuscular control in axial and/or frontal planes, offaxis neuromuscular control. The objective of this study was to investigate gender differences in offaxis neuromuscular control during stepping under...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-013-2727-3
更新日期：2013-11-01 00:00:00
abstract：PURPOSE:In tachymetabolic species, metabolic rate increases disproportionately with body mass, and that inter-specific relationship is typically modelled allometrically. However, intra-specific analyses are less common, particularly for healthy humans, so the possibility that human metabolism would also scale allometri...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-020-04515-1
更新日期：2021-01-01 00:00:00
abstract：PURPOSE:The aim of this study was to compare the efficacy of three water immersion interventions performed after active recovery compared to active recovery only on the resolution of inflammation and markers of muscle damage post-exercise. METHODS:Nine physically active men (n = 9; age 20‒35 years) performed an intens...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-020-04481-8
更新日期：2020-12-01 00:00:00
abstract：:This investigation was undertaken to examine the influence of intensity fluctuation on metabolic responses during and after exercise. Twenty-four males and 24 females were randomly assigned into one of the four groups consisting of 12 subjects of equal gender. Each group performed one of four 30-min exercise protocols...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-007-0424-9
更新日期：2007-06-01 00:00:00
abstract：:The aims of this study were (1) to evaluate changes in muscle activity associated with physiological fatigue and decreased swimming velocity (SV) during 200 m of front crawl swimming, and (2) to examine the relationship between the decreased SV and changes in kinematic or electromyogram parameters. Twenty swimmers par...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-012-2321-0
更新日期：2012-09-01 00:00:00
abstract：:In the past two decades oxygenation responses to incremental ramp exercise, measured non-invasively by means of near-infrared spectroscopy at different locations in the body, have advanced the insights on the underpinning mechanisms of the whole-body pulmonary oxygen uptake ([Formula: see text]) response. In healthy s...
journal_title：European journal of applied physiology
pub_type： 杂志文章,评审
doi：10.1007/s00421-016-3468-x
更新日期：2016-12-01 00:00:00
abstract：:The present investigation has been designed to confirm the effect of instruction (hard-and-fast instruction compared to fast instruction) upon maximal voluntary isometric force (MVF) and maximal rate of force development (MRFD) in muscle groups which differ with regards to muscle mass and usage. In addition, we took a...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210100451
更新日期：2001-08-01 00:00:00
abstract：:The purpose of this study was to examine the flow velocity pattern of the brachial artery and to determine its relationship to measures of physical function. Subjects from the Louisiana Healthy Aging Study (n = 95; age = 84 +/- 10 years) were evaluated. Brachial artery flow velocities and dimensions were measured usin...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-009-1117-3
更新日期：2009-09-01 00:00:00
abstract：PURPOSE:This pilot study investigated differences in lean tissue mass, muscle strength, muscle quality (strength per unit of muscle mass; MQ), and functional performance in healthy younger and older individuals. The most robust predictors of appendicular lean mass (ALM) were then determined in each group. METHODS:Fift...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-019-04107-8
更新日期：2019-05-01 00:00:00
abstract：:Appropriate technique choice may affect ski performance. V2 ski skating technique has in recent years become more widely applied on uphill terrain where V1 technique has typically been used. This investigation compared physiological responses of skiers using V1 and V2 techniques during uphill treadmill roller-skiing. ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-005-1332-5
更新日期：2005-10-01 00:00:00
abstract：:The role of exercise training (ET) on cardiac renin-angiotensin system (RAS) was investigated in 3-5 month-old mice lacking alpha(2A-) and alpha(2C-)adrenoceptors (alpha(2A)/alpha(2C)ARKO) that present heart failure (HF) and wild type control (WT). ET consisted of 8-week running sessions of 60 min, 5 days/week. In add...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0967-4
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:Autonomic assessment might be useful in training management. We planned to assess whether oscillatory metrics of RR variability (such as LFnu) would be more efficient than static indices from low order statistics (RR variance) at discriminating laying rest from stand posture, as an analog of a shift to sympathe...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-016-3337-7
更新日期：2016-04-01 00:00:00
abstract：PURPOSE:To determine if and how hypoxia combined with elevated carboxyhaemoglobin fraction (F HbCO) affects peripheral diffusing capacity and O2 extraction in animals exercising at their maximal aerobic capacity ([Formula: see text]). METHODS:Six goats ran on a treadmill at speeds eliciting [Formula: see text] while b...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-013-2799-0
更新日期：2014-04-01 00:00:00
abstract：:The purpose of this study was to examine the relationship between the energy cost (C) and the 3D intracycle velocity variation (IVV; swimming direction--x, vertical--y and lateral--z axes) throughout the 200 m front crawl event. Ten international level swimmers performed a maximal 200 m front crawl swim followed by 50...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-011-2284-6
更新日期：2012-09-01 00:00:00
