当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Alginate-based hydrogels for cancer therapy and research.

Alginate-based hydrogels for cancer therapy and research.

Abstract：

:Cancer is a major health issue concerning to all of us. Current treatment options are still limited due to not-selective action. Encapsulation is contemplated as an innovative approach to address systemic toxicity and tumor resistance caused by traditional therapies, while increasing encapsulated compounds bioavailability. The coating material of capsules strongly determines the success of the system. Since alginate has been proved non-toxic, biocompatible and biodegradable, it is considered a potential vehicle for therapeutic factors encapsulation. Besides, it has the particular ability to form hydrogels, which hold a high-water content and greatly resemble to natural soft tissues. The present review exposes the state-of-the-art and the most sophisticated alginate-based systems for cancer therapy and research. It begins with an overview of alginate hydrogels and the qualities that make them especially suitable for biomedical applications. In the following section, the application of alginate hydrogels as pioneering strategies for cancer treatment is described. Several examples of alginate-based delivery systems of therapeutic drugs, proteins and nucleic acids are provided. Significant emphasis is placed in both oral delivery systems and colorectal cancer therapy. Moreover, the role of alginate 3-D scaffolds for both cell culture and delivery is explained. Lastly, other applications of alginate-based hydrogels such as tumor biomarkers immunosensing and fluorescent surgical marker are included.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Reig-Vano B,Tylkowski B,Montané X,Giamberini M

doi

10.1016/j.ijbiomac.2020.12.161

subject

Has Abstract

pub_date

2021-02-15 00:00:00

pages

424-436

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)35335-6

journal_volume

170

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Fungicide methyl thiophanate binding at sub-domain IIA of human serum albumin triggers conformational change and protein damage.

    abstract：:Fluorescence quenching data on interaction of a fungicide methyl thiophanate (MT) with human serum albumin (HSA) elucidated a primary binding site at sub-domain IIA. Stern-Volmer algorithm and double log plot revealed the binding affinity (K(a)) and capacity (n) of HSA as 1.65 x 10(4)M(-1) and 1.0 (r(2)=0.99), respect...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2010.03.020

    authors： Saquib Q,Al-Khedhairy AA,Alarifi SA,Dwivedi S,Mustafa J,Musarrat J

    更新日期：2010-07-01 00:00:00

  • Strategies for screening, purification and characterization of bacteriocins.

    abstract：:Bacteriocins are bioactive antimicrobial peptides synthesized in the ribosome of numerous bacteria and released extracellularly. Bacteriocins have the ability to kill or inhibit the growth of prokaryotes and could potentially be useful against pathogens and antibiotic-resistant strains of bacteria. The antimicrobial m...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2018.05.233

    authors： Zou J,Jiang H,Cheng H,Fang J,Huang G

    更新日期：2018-10-01 00:00:00

  • Tailoring the surface properties and flexibility of starch-based films using oil and waxes recovered from potato chips byproducts.

    abstract：:Agrofood byproducts may be exploited as a source of biomolecules suitable for developing bioplastic materials. In this work, the feasibility of using starch, oil, and waxes recovered from potato chips byproducts for films production was studied. The recovered potato starch-rich fraction (RPS) contained an amylopectin/...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.06.231

    authors： Gonçalves I,Lopes J,Barra A,Hernández D,Nunes C,Kapusniak K,Kapusniak J,Evtyugin DV,Lopes da Silva JA,Ferreira P,Coimbra MA

    更新日期：2020-11-15 00:00:00

  • Inhibition of amyloid fibril formation and cytotoxicity by a chemical analog of Curcumin as a stable inhibitor.

    abstract：:Clinical application of curcumin for Alzheimer's disease treatment is severely limited with regard to its poor bioavailability, high rate of metabolism, and instability under neutral condition. In the current study, we designed three compounds in which the diketone moiety of curcumin was replaced by cyclohexanone. In ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.04.038

    authors： Ramshini H,mohammad-zadeh M,Ebrahim-Habibi A

    更新日期：2015-01-01 00:00:00

  • Rheological behavior of wheat starch and barley resistant starch (type IV) blends and their starch noodles making potential.

    abstract：:Barley starch citrate (BSC), a type IV resistant starch (RS) is associated with numerous health benefits when incorporated in bakery products. Physicochemical, pasting and rheological properties of the wheat starch (WS) and wheat starch-barley starch citrate (WS-BSC) blends and textural and sensorial attributes of whe...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.03.009

    authors： Punia S,Siroha AK,Sandhu KS,Kaur M

    更新日期：2019-06-01 00:00:00

  • Acid soaking followed by steam flash-explosion pretreatment to enhance saccharification of rice husk for poly(3-hydroxybutyrate) production.

    abstract：:In order to exploit an abundant and cheap carbon source for poly(3-hydroxybutyrate) (PHB) production, the rice husk was pretreated with dilute sulfuric acid and steam flash-explosion to enhance the enzymatic saccharification. The yield of reducing sugars of pretreated rice husk hydrolysate came up to 266.5 mg/g rice h...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.218

    authors： Zhang Y,Wang L,Li T,Shen Y,Luo J

    更新日期：2020-10-01 00:00:00

  • N-terminal residues are crucial for quaternary structure and active site conformation for the phosphoserine aminotransferase from enteric human parasite E. histolytica.

    abstract：:Phosphoserine aminotransferase (PSAT) is a pyridoxal-5'phosphate (PLP)-dependent enzyme that catalyzes the second reversible step in the phosphoserine biosynthetic pathway producing serine. The crystal structure of E. histolytica PSAT (EhPSAT) complexed with PLP was elucidated at 3.0 Å resolution and the structures of...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.04.027

    authors： Singh RK,Tomar P,Dharavath S,Kumar S,Gourinath S

    更新日期：2019-07-01 00:00:00

  • Simvastatin loaded composite polyspheres of gellan gum and carrageenan: in vitro and in vivo evaluation.

    abstract：:We investigated the lipid lowering ability of simvastatin loaded gellan gum-carrageenan composite polyspheres, which were prepared by ionotropic gelation/covalent crosslinking method. The surface morphology revealed that the polyspheres have rough and dense surface. The drug entrapment efficiency of the polyspheres pr...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.03.027

    authors： Kulkarni RV,Nagathan VV,Biradar PR,Naikawadi AA

    更新日期：2013-06-01 00:00:00

  • Selective separation of human serum albumin with copper(II) chelated poly(hydroxyethyl methacrylate) based nanoparticles.

    abstract：:Poly(hydroxyethyl methacrylate) (PHEMA) nanoparticles with an average size of 300 nm in diameter and with a polydispersity index of 1.156 were produced by surfactant free emulsion polymerization. Specific surface area of the PHEMA nanoparticles was found to be 996 m(2)/g. Metal-chelating ligand 3-(2-imidazoline-1-yl)p...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2009.04.023

    authors： Karakoc V,Yilmaz E,Türkmen D,Oztürk N,Akgöl S,Denizli A

    更新日期：2009-08-01 00:00:00

  • Biochemical characterization and mutational studies of a thermostable uracil DNA glycosylase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5.

    abstract：:Uracil DNA glycosylases (UDGs) play an important role in removing uracil from DNA to initiate DNA base excision repair. Here, we characterized biochemically a thermostable UDG from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5 (Tba UDG), and probed its mechanism by mutational analysis. The recombinant...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.05.073

    authors： Shi H,Gan Q,Jiang D,Wu Y,Yin Y,Hou H,Chen H,Xu Y,Miao L,Yang Z,Oger P,Zhang L

    更新日期：2019-08-01 00:00:00

  • A gellan gum derivative as in-situ gelling cationic polymer for nasal drug delivery.

    abstract：:The aim of the present study was the development of a novel gellan gum derivative exhibiting mucoadhesive properties for nasal application. Accomplishing this, amino groups have been introduced to the polymeric backbone. The resulting synthesis products were characterized in terms of the amount of attached amino group...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.114

    authors： Jelkmann M,Leichner C,Zaichik S,Laffleur F,Bernkop-Schnürch A

    更新日期：2020-05-04 00:00:00

  • Non-classical secretion of 1,4-alpha-glucan branching enzymes without signal peptides in Escherichia coli.

    abstract：:1,4-α-Glucan branching enzyme (GBE, EC. 2.4.1.18), which plays a key role in the synthesis of starch and glycogen, has been overexpressed in E. coli as an intracellular enzyme by many researchers. In this study, it was found that the GBEs from Geobacillus thermoglucosidans and Rhodothermus obamensis were secreted into...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.04.002

    authors： Xin C,Ban X,Gu Z,Li C,Cheng L,Hong Y,Li Z

    更新日期：2019-07-01 00:00:00

  • Purification and characterization of thermostable superoxide dismutase from Anoxybacillus gonensis KA 55 MTCC 12684.

    abstract：:A thermostable superoxide dismutase from thermophilic bacterium Anoxybacillus gonensis KA 55 MTCC 12684 which was isolated from Manikaran hotspring of Himachal Pradesh was purified to apparent homogeneity by fractional ammonium sulphate precipitation and anion exchange chromatography. A purification factor of 33.1-fol...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.06.031

    authors： Bhatia K,Mal G,Bhar R,Jyoti,Attri C,Seth A

    更新日期：2018-10-01 00:00:00

  • Depolymerized sulfated galactans from Eucheuma serra ameliorate allergic response and intestinal flora in food allergic mouse model.

    abstract：:The ameliorative effect of depolymerized sulfated polysaccharides from Eucheuma serra (DESP) on ovalbumin (OVA)-caused induced food allergy was investigated in this work. Results showed that OVA stimulated the secretion of allergy-related cytokines (OVA-specific IgE, mMCP-1, IgA, TNF-α) and led to diarrhea, intestinal...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.10.254

    authors： Liu Y,Ma Y,Chen Z,Zou C,Liu W,Yang L,Fu L,Wang Y,Liu GM,Cao MJ

    更新日期：2021-01-01 00:00:00

  • Xyloglucan-based hybrid nanocomposite with potential for biomedical applications.

    abstract：:Natural polymer-based hybrid nanocomposites have been proposed as one of the most promising tools for biomedical applications, including disease treatment and diagnosis procedures. Xyloglucan nanocapsules can simultaneously load magnetic iron oxide nanoparticles and bioactive for a specific tissue, reducing the proces...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.128

    authors： da Silva ACC,de Almeida RR,da Cruz Sousa AC,Martínez FNA,Denardin JC,de Morais SM,Ricardo NMPS

    更新日期：2021-01-31 00:00:00

  • Purification, characterization and antitumor activity of an exopolysaccharide produced by Bacillus velezensis SN-1.

    abstract：:A capsular polysaccharides (CPS) producer Bacillus velezensis SN-1 (B. velezensis SN-1) was isolated in Da-jiang, China. We used ultrasonic extraction to obtain CPS from a culture of B. velezensis SN-1 at a yield of 755 mg/L. Using gel permeation chromatography (GPC), CPS was separated into a single peak with a molecu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.024

    authors： Cao C,Li Y,Wang C,Zhang N,Zhu X,Wu R,Wu J

    更新日期：2020-08-01 00:00:00

  • The effect of carotenoids obtained from saffron on histone H1 structure and H1-DNA interaction.

    abstract：:It is already known that transcriptional activation of genes occurs due to the H1 dissociation from linker DNA; hence, histone H1-DNA complex is considered as a model of chromatin. Anticancer property of saffron and its carotenoids has already been reported. The present study aimed at investigating the effect of saffr...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.05.008

    authors： Ashrafi M,Bathaie SZ,Taghikhani M,Moosavi-Movahedi AA

    更新日期：2005-09-15 00:00:00

  • Inhibition of normal and waxy corn starch retrogradation by sodium borohydride.

    abstract：:After gelatinization, starch is prone to retrograde during storage, and it is a notorious challenge to inhibit starch retrogradation in papermaking, textile, and construction fields. This work aimed to develop a new method for inhibiting the retrogradation of normal corn starch (CS) and waxy corn starch (WCS) by sodiu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.03.017

    authors： Yu M,Xu Z,Ji N,Dai L,Xiong L,Sun Q

    更新日期：2020-06-15 00:00:00

  • Encapsulation of lipase using magnetic fluorescent calix[4]arene derivatives; improvement of enzyme activity and stability.

    abstract：:In this study, iron magnetic nanoparticles capped with fluorescent calixarene derivatives (Fe3O4@Calix-2 and Fe3O4@Calix-3) were prepared in one-step using coprecipitation of Fe(II) and Fe(III) in basic solution. Different techniques were used to characterize the synthesized magnetic nanoparticles, such as Fourier Tra...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.04.182

    authors： Ozyilmaz E,Cetinguney S,Yilmaz M

    更新日期：2019-07-15 00:00:00

  • Structure function relationships of transgenic starches with engineered phosphate substitution and starch branching.

    abstract：:Potato tuber starch was genetically engineered in the plant by the simultaneous antisense suppression of the starch branching enzyme (SBE) I and II isoforms. Starch prepared from 12 independent lines and three control lines were characterised with respect to structural and physical properties. The lengths of the amylo...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.05.006

    authors： Blennow A,Wischmann B,Houborg K,Ahmt T,Jørgensen K,Engelsen SB,Bandsholm O,Poulsen P

    更新日期：2005-08-01 00:00:00

  • Systematic conformational search for the branching point of amylopectin.

    abstract：:A systematic modelling for the branching point of amylopectin, on the basis of the double-helical structure proposed for amylose polymorphs was performed. A 'several steps' approach was used with increasing sophistication in the refinement, combining the use of geometrical criteria and molecular mechanics calculations...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(90)90041-8

    authors： Buléon A,Tran V

    更新日期：1990-12-01 00:00:00

  • Viscosity of alpha-crystallin solutions.

    abstract：:Accommodation in the mammalian lens requires flexure of lens fibres and some redistribution of their contents involving limited viscous flow. Shear-dependent viscosity of bovine alpha-crystallin solutions was determined with the Contraves Low-Shear Rheometer between 4.4 and 347 mg ml(-1), and at 15.5, 25, 30, and 37 d...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(02)00018-1

    authors： Tiffany JM,Koretz JF

    更新日期：2002-06-18 00:00:00

  • Surface modification of microcrystalline cellulose: Physicochemical characterization and applications in the Stabilization of Pickering emulsions.

    abstract：:The phenomenon of polymer adsorption was applied to modify the surface of microcrystalline cellulose (MCC). The active polymer sodium carboxymethyl cellulose (CMCNa), having different molecular weight was used to produce modified MCCs. The average particle size of unmodified MCC was about 14.208 ± 0.064 μm, and it was...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.04.051

    authors： Ahsan HM,Zhang X,Li Y,Li B,Liu S

    更新日期：2019-07-01 00:00:00

  • Different unfolding pathways of homologous alpha amylases from Bacillus licheniformis (BLA) and Bacillus amyloliquefaciens (BAA) in GdmCl and urea.

    abstract：:Understanding the factors governing stability of proteins is fundamentally and industrially important topic in protein science. Bacterial alpha amylases are industrially important enzymes which are involved in the breakage of α-1, 4-glycosidic bonds in starch. Current study is focussed on elucidating the role of non-c...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.139

    authors： Ahmad A,Mishra R

    更新日期：2020-09-15 00:00:00

  • Green synthesis of biopolymer-silver nanoparticle nanocomposite: an optical sensor for ammonia detection.

    abstract：:Biopolymer used for the production of nanoparticles (NPs) has attracted increasing attention. In the presence article we use aqueous solution of polysaccharide Cyamopsis tetragonaloba commonly known as guar gum (GG), from plants. GG acts as reductive preparation of silver nanoparticles which are found to be <10 nm in ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.06.033

    authors： Pandey S,Goswami GK,Nanda KK

    更新日期：2012-11-01 00:00:00

  • On the relationship between the conserved 'black' and 'gray' structural clusters and intrinsic disorder in parvalbumins.

    abstract：:Recently we found two highly conserved structural motifs in the members of the EF-hand protein family, which provide a supporting scaffold for their Ca2+ binding loops. Each structural motif is formed by a cluster of three amino acids. These clusters were called 'black' cluster (cluster I) and 'gray' cluster (cluster ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.08.183

    authors： Deryusheva EI,Denesyuk AI,Denessiouk K,Uversky VN,Permyakov SE,Permyakov EA

    更新日期：2018-12-01 00:00:00

  • The effects of HHP (high hydrostatic pressure) on the interchain interaction and the conformation of amylopectin and double-amylose molecules.

    abstract：:Starch is an important resource in nature, and HHP (high hydrostatic pressure) is one of the most important physical modification technologies. In this study, molecular dynamics simulation was used to explore the interchain interaction and the changes of molecule conformations of amylopectin and double-amylose helix a...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.03.190

    authors： Zhi-Guang C,Jun-Rong H,Hua-Yin P,Qi Y,Chen-Lu F

    更新日期：2020-07-15 00:00:00

  • Structural characteristics and properties of the regenerated silk fibroin prepared from formic acid.

    abstract：:Structural characteristics and thermal and solution properties of the regenerated silk fibroin (SF) prepared from formic acid (FU) were compared with those of SF from water (AU). According to the turbidity and shear viscosity measurement, SF formic acid solution was stable and transparent, no molecular aggregations oc...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(01)00159-3

    authors： Um IC,Kweon HY,Park YH,Hudson S

    更新日期：2001-08-20 00:00:00

  • Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides.

    abstract：:Hericium erinaceus polysaccharide (HEP) is a traditional Chinese medicine. In the present study, chemical composition and antioxidant activity of HEP was investigated. HPLC analysis showed that the HEP was composed of xylose (7.8%), ribose (2.7%), glucose (68.4%), arabinose (11.3%), galactose (2.5%) and mannose (5.2%)...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.09.009

    authors： Han ZH,Ye JM,Wang GF

    更新日期：2013-01-01 00:00:00

  • Improving the cellobiose-hydrolysis activity and glucose-tolerance of a thermostable β-glucosidase through rational design.

    abstract：:β-Glucosidase is the rate-limiting component of a cellulase-hydrolyzing reaction. Thermostability and glucose-tolerance are two critical criteria of the enzyme, which practically determine its performance in industrial applications. In this study, a thermostable and glucose-tolerant β-glucosidase (named Bgl1317) belon...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.06.029

    authors： Liu X,Cao L,Zeng J,Liu Y,Xie W

    更新日期：2019-09-01 00:00:00