Abstract:
:As an important nano-material, nano-copper oxide particles (CuO-ENPs) harbor a vast range of characteristics, including electronic correlation effect, thermal stability, catalytic activity, sterilization and other properties. At present, the mechanism of ecotoxicological effects of CuO-ENPs is not yet clear, and has been inconclusive. Therefore, we aimed to explore the ecotoxicological effects of nano-copper oxide particles (CuO-ENPs) to Portunus trituberculatus. The crabs were exposed in sea water contained different concentrations of CuO-ENPs to conduct the acute toxicity test and chronic accumulation test. Acute toxicity, metal accumulation and SOD activity in different tissues were determined. We found that lethal concentration of 50% 96 h LC50 of CuO-ENPs to Portunus trituberculatus belonged to low toxicity. The accumulation of CuO-ENPs in different tissues from high to low was: gill > haemolymph > muscle > hepatopancreas > heart and stomach, and decreased gradually with time after reached maximum. Subsequencely, it was in relative steady state after a certain period and showed an obvious concentration effect. With the increment of exposure time and concentration of CuO-ENPs, the SOD activities in different tissues were quite different. In conclusion, the 96 h LC50 of CuO-ENPs to Portunus trituberculatus was 49 mg/L, and its toxicity belonged to low toxicity. With the increment of exposure time and concentration of CuO-ENPs, the SOD activities in different tissues were quite different, which were increased remarkably in gill and hepatopancreas, but were suppressed at early stage of exposure in muscle and haemolymph.
journal_name
Curr Pharm Biotechnoljournal_title
Current pharmaceutical biotechnologyauthors
Li T,Hu H,Yang C,Zhang B,Ma Ldoi
10.2174/1389201021666201229111251subject
Has Abstractpub_date
2020-12-28 00:00:00eissn
1389-2010issn
1873-4316pii
CPB-EPUB-112775pub_type
杂志文章abstract::Elaborate repair pathways counteract the deleterious effects of DNA damage by mechanisms that are understood in reasonable detail. In contrast, repair of damaged RNA has not been widely explored. This may be because aberrant RNAs are generally assumed to be degraded rather than repaired. The reason for this view is we...
journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章,评审
doi:10.2174/138920107783018363
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章,评审
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章,评审
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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doi:10.2174/1389201021666201009153808
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
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journal_title:Current pharmaceutical biotechnology
pub_type: 杂志文章,评审
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journal_title:Current pharmaceutical biotechnology
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doi:10.2174/138920111795164066
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journal_title:Current pharmaceutical biotechnology
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更新日期:2021-01-18 00:00:00
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更新日期:2015-01-01 00:00:00
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