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Pantoprazole impairs fracture healing in aged mice.

Abstract：

:Proton pump inhibitors (PPIs) belong to the most common medication in geriatric medicine. They are known to reduce osteoclast activity and to delay fracture healing in young adult mice. Because differentiation and proliferation in fracture healing as well as pharmacologic actions of drugs markedly differ in the elderly compared to the young, we herein studied the effect of the PPI pantoprazole on bone healing in aged mice using a murine fracture model. Bone healing was analyzed by biomechanical, histomorphometric, radiological and protein biochemical analyses. The biomechanical analysis revealed a significantly reduced bending stiffness in pantoprazole-treated animals when compared to controls. This was associated with a decreased amount of bone tissue within the callus, a reduced trabecular thickness and a higher amount of fibrous tissue. Furthermore, the number of osteoclasts in pantoprazole-treated animals was significantly increased at 2 weeks and decreased at 5 weeks after fracture, indicating an acceleration of bone turnover. Western blot analysis showed a lower expression of the bone morphogenetic protein-4 (BMP-4), whereas the expression of the pro-angiogenic parameters was higher when compared to controls. Thus, pantoprazole impairs fracture healing in aged mice by affecting angiogenic and osteogenic growth factor expression, osteoclast activity and bone formation.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Menger MM,Bremer P,Scheuer C,Rollmann MF,Braun BJ,Herath SC,Orth M,Später T,Pohlemann T,Menger MD,Histing T

doi

10.1038/s41598-020-79605-3

subject

Has Abstract

pub_date

2020-12-23 00:00:00

pages

22376

issue

1

issn

2045-2322

pii

10.1038/s41598-020-79605-3

journal_volume

10

pub_type

杂志文章

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